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Faculty Detail     Name KAREN LYNNETTE GAMBLE   Campus Address SC 720 Zip 0017 Phone 205-934-4663 E-mail klgamble@uab.edu Other websites

Education Undergraduate  King College    1996  B.A.  Graduate  Georgia State University    2001  M.A.  Graduate  Georgia State University    2004  Ph.D.  Fellowship  Vanderbilt University    2009  Postdoctoral Training

Certifications Clinical and Translational Science Training Program, UAB CCTS  2012

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Psychiatry   Psych - Behavioral Neurobiology Assistant Professor Secondary  Neurobiology  Neurobiology Assistant Professor Center  General Clinical Research Center  Comprehensive Neuroscience Center Assistant Professor Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Assistant Professor

Biographical Sketch  King College Bristol, TN B.A.(Psychology) 1993-1996 Georgia State University Atlanta, GA M.A. (Neuropsychology) 1999-2001 Georgia State University Atlanta, GA Ph.D. (Neuropsychology) 2001-2004 Vanderbilt University, Nashville, TN Postdoctoral Fellowship Biological Sciences 2004-2009

Society Memberships Organization Name Position Held Org Link Society for Neuroscience  Member  www.sfn.org  Society for Research in Biological Rhythms  Member  www.srbr.org  Society for Research in Biological Rhythms  2012 Facilities Coordinator    Society for Research in Biological Rhythms  2012 Travel Awards Committee, Member    Society for Research in Biological Rhythms  2014 Trainee Day Committee, Organizer    Society for Research in Biological Rhythms  2012 Trainee Day Committee, Member

Research/Clinical Interest Title Description Mechanisms and Entrainment of Circadian Clocks The mammalian brain’s primary biological clock (the suprachiasmatic nucleus or SCN) drives daily physiological and behavioral rhythms that persist in the absence of environmental time cues with a near-24 hour period. When the endogenous clock is misaligned with the external environment such as during jet lag and shift work, serious repercussions can result, not only for the circadian system but also for the entire body. For example, shift work is associated with an increased risk of gastrointestinal disorders, cardiovascular disease, depression, and cancer. Clinically, sleep and circadian rhythm disturbances have been linked to neurodegenerative diseases as well as mood and developmental disorders. Given the range of circadian physiological processes, it is not surprising that ~24-hour rhythms in the expression of the core clock genes or electrical activity have been discovered throughout the brain and body. Therefore, determining underlying mechanisms for the types of stimuli that can “reset” and re-align the clock with the environment is important for developing novel therapeutic approaches. The overall goal of my research program is to investigate how the mammalian clock integrates environmental and molecular signals into robust behavioral and physiological rhythms. The complementary and translational side of this goal is to determine how neurological diseases and disruptive environments (such as shift work) result in dysregulated circadian rhythms that exacerbate disease symptoms. To this end, the projects in my lab can be divided into three primary categories: (i) underlying neurophysiological mechanisms of entrainment in of SCN neurons, (ii) the role of rhythmic regulation of glycogen synthase kinase 3 in the brain and periphery, and (iii) circadian misalignment in shift work nurses. Our laboratory is currently using circadian behavioral analysis, tissue-level imaging and pharmacology, as well as targeted fluorescence electrophysiology in transgenic mouse models to investigate the neural circuitry of the SCN. In clinical studies of shift work nurses, we are measuring circadian rhythms in sleep-wake behavior (actigraphy), diet/nutrition, plasma metabolites, and clock gene expression rhythms in peripheral mononuclear cells to determine the effects of shift work on circadian misalignment.

Selected Publications  Publication PUBMEDID Fargason R.E., White S., Hollar A., and Gamble, K. (2012). Adults with Attention-deficit Hyperactivity Disorder without Insomnia have Subclinical Sleep Disturbances but not Circadian Delay: An ADHD Phenotype? J of Attention Dis, in press.  22997357  Paul, J.R., Johnson, R.L., Jope, R.S., and Gamble, K.L. (2012). Disruption of circadian rhythmicity and suprachiasmatic action potential frequency in a mouse model with constitutive activation of glycogen synthase kinase-3. Neuroscience, 226, 1-9.  22986169  Zhou, W., Chen, L., Paul, J.R., Yang, S., Li F., Sampson, K., Woodgett, J.R., Beaulieu, J.M., Gamble, K.L., and Li, X. (2012). The Effects of Glycogen Synthase Kinase-3beta in Serotonin Neurons. PloS ONE, 7(8), e43262.  22912839  Bray, M.S., Ratcliffe, W.F., Grenett, M.H., Brewer, R.A., Gamble, K.L., and Young, M.E. (2012). Quantitative Analysis of Light-Phase Restricted Feeding Reveals Metabolic Dyssynchrony in Mice. Int J Obesity, in press.  22907695  Jackson, C.R., Ruan, G., Aseem, F., Abey, J., Gamble, K., Stanwood, G., Palmiter, R.D., Iuvone, P.M., and McMahon, D.G. (2012). Retinal dopamine mediates multiple dimensions of light-adapted vision. J Neurosci, 32(27), 9359-68.  22764243  Ruan, G., Gamble, K.L., Risner, M., Young, L., and McMahon, D.G. (2012). Divergent Roles of clock genes in retinal and suprachiasmatic nucleus circadian oscillators. PLoS ONE, 7(6), e38985.  22701739  DeAndrade, M.P., Johnson Jr., R.L., Unger, E.L., Zhang, L., van Groen, T., Gamble, K.L., and Li,Y. (2012). Motor restlessness, sleep disturbances, thermal sensory alterations, and elevated serum iron levels in Btbd9 mutant mice. Hum Mol Gen, 21(18), 3984-92.  22678064  Dougherty SE, Reeves JL, Lucas EK, Gamble KL, Lesort M, and Cowell RM (2012). Disruption of Purkinje cell function prior to huntingtin accumulation and cell loss in an animal model of Huntington Disease. Exp Neurol, 236(1), 171-8.  22579526  Besing, R.C., Hablitz, L.M., Paul, J.R., Johnson, R.L., Prosser, R.A., & Gamble, K.L. (2012). NPY-induced phase shifts of PER2::LUC rhythms are mediated by long-term suppression of neuronal excitability in a phase-specific manner. Chronobiol Int, 29(2), 91-102.  22324550  Durgan, D.J., Pat, B.M., Laczy, B., Bradley, J.A., Tsai, J., Grenett, M.H., Ratcliffe,W.F., Brewer, R.A., Nagendran, J., Villegas-Montoya, C., Zou, C., Johnson, R.L., Dyck, J.R.B., Bray, M.S., Gamble, K.L., Chatham, J.C., and Young, M.E. (2011). O-GlcNAcylation: A novel post-translational modification linking myocardial metabolism and the cardiomyocyte circadian clock. Journal of Biol Chem, 286(52) 44606-19.  22069332  First Prev   1 2 3 of  3  Next Last

Keywords circadian rhythms, biological clocks, shift work, entrainment, suprachiasmatic nucleus

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