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Faculty Detail     Name DAVID GEORGE STANDAERT   Campus Address CIRC 516 Zip 0021 Phone 205-996-6329 E-mail dstandaert@uab.edu Other websites www.uab.edu/CNET

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Neurology   Neurology Chair Office Professor Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Professor Secondary  Neurobiology  Neurobiology Professor Secondary  Pharmacology/Toxicology   Pharmacology/Toxicology Chair's Office Professor Center  Neurology   Alzheimer's Disease Center Professor Center  Arthritis & Musculoskeletal Diseases Center  Arthritis & Musculoskeletal Diseases Center Professor Center  General Clinical Research Center  Comprehensive Neuroscience Center Professor Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Professor Center  Cell, Developmntl, & Integrative Biology  Ctr for Exercise Medicine Professor Center  Ctr for Glial Bio in Med  Ctr for Glial Bio in Med Professor Center  Neurology   Ctr Neurodegeneration & Exp Ther (CNET) Professor

Graduate Biomedical Sciences Affiliations Cell, Molecular, & Developmental Biology  Cellular and Molecular Biology Program  Genetics and Genomic Sciences  Integrative Genetics Graduate Program  Medical Scientist Training Program  Neuroscience  Neuroscience Graduate Program  Pathobiology and Molecular Medicine

Biographical Sketch  Dr. Standaert received his M.D. and Ph.D. degrees from Washington University in St. Louis in medicine and pharmacology in 1988. He completed a one-year internship in medicine at Jewish Hospital of St. Louis in 1989 and a three-year neurology residency in 1992 at the University of Pennsylvania. He completed a three-year research and clinical fellowship in neurology (movement disorders) at Harvard Medical School Massachusetts General Hospital in 1995. Dr. Standaert is licensed to practice medicine in the states of Massachusetts and Alabama and was board certified in 1993 by the American Board of Psychiatry and Neurology. Dr. Standaert joined the Faculty at UAB in July of 2006 as the John and Juanelle Strain Professor and serves as Director of the Center for Neurodegeneration and Experimental Therapeutics, Director of the Division of Movement Disorders in the Department of Neurology, and the Director of the American Parkinson Disease Association (APDA) Advanced Center for Parkinson Research. He sees patients in a weekly clinic and oversees many clinical trials for new treatments of Parkinson's disease.

Society Memberships Organization Name Position Held Org Link American Academy of Neurology  Member    American Neurological Association  Member    Movement Disorders Society  Member    Parkinson Study Group  Member    Society for Neuroscience  Member

Research/Clinical Interest Title Translational Research in Neurodegenerative Diseases Description Dr. Standaert’s laboratory works on understanding both the root causes of Parkinson’s disease as well as the origin of the disabling symptoms that appear after long term treatment of the disease. Recently, his group has focused on the role of abnormal gene expression in brain as a cause of Parkinson disease. They are using new animal models of Parkinson’s, including both conventional transgenic mice as well a model produced using a viral approach similar to “gene therapy.” The analysis of these models is conducted with advanced tools including both Laser Capture Microdissection, which allows isolation of a single cell, as well as gene array techniques to study as many as 36,000 genes in a single experiment. Dr. Standaert’s laboratory is also interested in the cause of “wearing off” and “dyskinesias” which occur in patients treated with levodopa, and has uncovered evidence which may lead to new treatments for these disabling problems.

Selected Publications  Publication PUBMEDID Martella G, Tassone A, Sciamanna G, Platania P, Cuomo D, Viscomi MT, Bonsi P, Cacci E, Biagioni S, Usiello A, Bernardi G, Sharma N, Standaert DG, Pisani A. Impairment of bidirectional synaptic plasticity in the striatum of a mouse model of DYT1 dystonia: role of endogenous acetylcholine. Brain. 2009 Sep;132(Pt 9):2336-49. Epub 2009 Jul 29.   19641103  Sciamanna G, Bonsi P, Tassone A, Cuomo D, Tscherter A, Viscomi MT, Martella G, Sharma N, Bernardi G, Standaert DG, Pisani A. Impaired striatal D2 receptor function leads to enhanced GABA transmission in a mouse model of DYT1 dystonia. Neurobiol Dis. 2009 Apr;34(1):133-45.   19187797  107. Crittenden JR, Cantuti-Castelvetri I, Saka E, Keller-McGandy CE, Hernandez LF, Kett LR, Young AB, Standaert DG, Graybiel AM. Dysregulation of CalDAG-GEFI and CalDAG-GEFII predicts the severity of motor side-effects induced by anti-parkinsonian therapy. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2892-6.   19171906  Patel S, Hughes R, Huggins N, Standaert D, Growdon J, Dy J, Bonato P. Using wearable sensors to predict the severity of symptoms and motor complications in late stage Parkinson's Disease. Conf Proc IEEE Eng Med Biol Soc. 2008;2008:3686-9  19163512  Theodore S, Cao S, McLean PJ, Standaert DG. Targeted overexpression of human alpha-synuclein triggers microglial activation and an adaptive immune response in a mouse model of Parkinson disease. J Neuropathol Exp Neurol. 2008 Dec; 67(12): 1149-58.   19018246  Yacoubian TA, Standaert DG. Targets for neuroprotection in Parkinson’s disease. Biochim Biophys Acta. 2009 Jul;1792(7):676-87. Epub 2008 Oct 1. Review.   18930814  Schifitto G, Friedman JH, Oakes D, Shulman L, Comella CL, Marek K, Fahn S; Parkinson Study Group ELLDOPA Investigators. Fatigue in levodopa-naive subjects with Parkinson disease. Neurology. 2008 Aug 12;71(7):481-5  18695158  Nicholas AP, Lubin FD, Hallett PJ, Vattem P, Ravenscroft P, Bezard E, Zhou S, Fox SH, Brotchie JM, Sweatt JD, Standaert DG. Striatal histone modifications in models of levodopa-induced dyskinesia. J Neurochem. 2008 Jul;106(1):486-94.   18410512   Raju DV, Ahern TH, Shah DJ, Wright TM, Standaert DG, Hall RA, Smith Y. Differential synaptic plasticity of the corticostriatal and thalamostriatal systems in an MPTP-treated monkey model of parkinsonism. Eur J Neurosci. 2008 Apr;27(7);1647-58.   18380666  Breakefield XO, Blood AJ, Li Y, Hallett M, Hanson PI, Standaert DG. The pathophysiological basis of dystonias. Nat Rev Neurosci. 2008 Mar;9(3):222-34.   18285800  First Prev   1 2 of  2  Next Last

Keywords Parkinsons Disease, Dystonia, Movement Disorders

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