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Faculty Detail    
Name DAVID E BRILES
 
Campus Address BBRB 658 Zip 2170
Phone 205-934-6595
E-mail dbriles@uab.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Microbiology  Microbiology Professor
Secondary  Genetics   Genetics Chair Office Professor
Secondary  Pediatrics   Pediatrics Chair Office Professor
Center  Arthritis & Musculoskeletal Diseases Center  Arthritis & Musculoskeletal Diseases Center Professor
Center  Center for Aging  COMPREHENSIVE CTR FOR HEALTHY AGING Professor
Center  Center for AIDS Research  Center for AIDS Research Professor
Center  Center for Biophysical Sciences/Engineering  Center for Biophysical Sciences/Engineering Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Professor
Center  Cystic Fibrosis Research Center  Cystic Fibrosis Research Center Professor

Graduate Biomedical Sciences Affiliations
Cellular and Molecular Biology Program 
Genetics and Genomic Sciences 
Immunology 
Integrative Genetics Graduate Program 
Medical Scientist Training Program 
Microbiology 

Biographical Sketch 
David E. Briles (b.1945), Professor of Microbiology and Pediatrics, did his graduate work on the genetic regulation of antibody binding site structure at The Rockefeller University in New York City with Dr. Richard Krause. Dr. Briles' postdoctoral studies, with Dr. Joseph Davie at Washington University Medical School in St. Louis, dealt with the expression of antibody diversity in antibacterial antibody responses and the genetic control of susceptibility of mice to Salmonella and pneumococcal infection. He joined the UAB faculty in 1978. His is presently working on the molecular biology and genetics of bacterial pathogenesis, bacterial vaccines, and epidemiology of bacterial infections. Together with other colleagues at UAB and past trainees he holds a number of patents on pneumococcal vaccine antigens. His present studies are on protein virulence factors of pneumococci, their mechanisms of action and potential use in vaccines. In recent years his lab has worked to develope surrogate assays for protective immunity to pneumococcal protein antigens. Dr. Briles has served on several study sections at the NIH and FDA and editorial several boards. He has been an advisor about the potential of pneumococcal proteins as human vaccine to the WHO, PAHO, FDA, and the PATH foundation. Dr. Briles is also a faculty member at SungKyunKwan University in South Korea where he spends two months each year as a WCU scholar. He is also an Adjunct Professor at Northern Illinois University, DeKalb, Illinois. Dr. Briles is married and has two grown children. His hobby is tree farming.

Society Memberships
Organization Name Position Held Org Link
American Academy of Microbiology  Fellow   
American Association for the Advancement of Science (AAAS)  Member   
American Association of Immunologists  Member   
American Society for Microbiology (ASM)   Member   
Infectious Disease Society of America  Member   
National Academy of Inventors  Fellow   

Research/Clinical Interest
Title
Pneumococcal virulence factors; mechanisms of action and use in vaccine
Description
We study the interactions of host defenses and bacterial virulence factors in the pathogenesis of bacteria. Our approach is to use both bacterial and animal genetics to identify and study important mechanisms in protection and virulence. We have identified a cell wall protein of pneumococci, PspA, which is important for pneumococcal virulence and which may be useful as a vaccine for very young children. Studies are underway to characterize the protection-eliciting portion of PspAs from different childhood strains of pneumococci, and to assemble these into an effective human vaccine with other pneumococcal proteins. We are studying the mode of action of several pneumococcal virulence factors including PspA, pneumolysin, PspC, PsaA, PcpA, and NanA, and are investigating the possibility of developing a pneumococcal vaccine that would prevent pneumococcal carriage. In other studies, we are investigating the effects of specific immunity and inflammation induced host immunity on the in vivo killing and growth rates of Streptococcus pneumoniae. In collaboration with Drs. Crain in Pediatrics and Nahm in Pathology, we have examined the changing distributions of capsular polysaccharides and protein antigens in human pneumococcal isolates.

Selected Publications 
Publication PUBMEDID
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Keywords
Streptococcus pneumoniae, virulence, host immunity, vaccines, virulence factors, mechanisms of virulence, vaccine antigens