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Faculty Detail    
Name LIZHONG WANG
 
Campus Address KAUL 740 Zip 0024
Phone 205-934-5948
E-mail lwang12@uab.edu
Other websites
     

Education
Medical School  China Medical University    1988  M.D. 
Graduate  Akita University, Japan    2002  Ph.D. 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Genetics   Genetics Research Div Assistant Professor
Center  Arthritis & Musculoskeletal Diseases Center  Arthritis & Musculoskeletal Diseases Center Assistant Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Assistant Professor
Center  General Clinical Research Center  Comprehensive Neuroscience Center Assistant Professor

Society Memberships
Organization Name Position Held Org Link
American Association for Cancer Research     
American Association for the Advancement of Science     

Research/Clinical Interest
Title
Cancer Genetics
Description
Our research interests focus on the cancer genetics and molecular epidemiology involved in prostate cancer and breast cancer. Our recent research showed that the somatic genetic alterations in a novel tumor suppressor gene FOXP3 with a single-hit mechanism have an important impact on developing both breast cancer and prostate cancer. We are going to investigate the molecular mechanisms of tumor development and progression in multiple signaling pathways. Our current projects include 1) identifying the cancer-causing genes, targets, and pathways; 2) determining the genetic mechanism of tumor invasion and metastasis; 3) establishing the principle of tumor suppressors relay between FOXP3 and noncoding RNA; 4) developing human-like animal models of prostate cancer.

Selected Publications 
Publication PUBMEDID
Wang L, Lin S, Rammohan KW, Liu Z, Liu JQ, LiuRH, Guinther N, Lima J, Zhou Q, Wang T, Zheng X, Birmingham DJ, Rovin BH, Hebert LA, Wu Y, Lynn DJ, Cooke G, Yu CY, Zheng P, Liu Y. A Di-nucleotide Deletion in CD24 Confers Protection against Autoimmune Diseases. PLoS Genetics, 2007 Apr 6;3(4):508-17.

Zuo T, Wang L, Morrison C, Chang X, Zhang H, Li W, Liu Y, Wang Y, Liu X, Chan MWY, Liu JQ, Love R, Liu CG, Godfrey V, Shen R, Huang THM, Yang T, Park BK, Wang CY, Zheng P, Liu Y. FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene. Cell, 2007 June 29; 129 (7): 1275-86.

Liu R, Wang L, Chen C, Liu Y, Zhou P, Wang Y, Wang X, Turnbull J, Minassian BA, Liu Y, Zheng P. Laforin negatively regulates cell cycle progression through GSK-3{beta} dependent mechanisms. Mol Cell Biol. 2008 Dec; 28 (23):7236-44.

Liu R, Wang L, Chen C, Katoh H, Chen C, Zheng P, Liu Y. FOXP3 up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/4 association to the locus. Cancer Res. 2009 Mar 15; 69 (6): 2252-9.

Wang L, Liu R, Li W, Chen C, Katoh H, Chen GY, McNally B, Lin L, Zhou P, Zuo T, Cooney KA, Liu Y, Zheng P. Somatic Single-hits Inactivate the X-linked Tumor Suppressor FOXP3 in the Prostate. Cancer Cell, 2009 Oct 6; 16 (4):336-46.

Li W, Wang L, Katoh H, Liu R, Zheng P, Liu Y. Identification of a tumor suppressor relay between the FOXP3 and the Hippo pathways in breast and prostate cancers. Cancer Res. 2011 Mar 15; 71 (6): 2162-71.

Wang L, Liu R, Li D, Lin S, Fang X, Backer G, Kain M, Rammoham K, Zheng P, Liu Y. A hypermorphic SP1-binding CD24 variant associates with risk and progression of multiple sclerosis. Am J Transl Res. 2012;4(3):347-56.

Wang CM, Brennan VC, Gutierrez NM, Wang X, Wang L, Yang WH. SUMOylation of ATF3 alters its transcriptional activity on regulation of TP53 gene. J Cell Biochem. 2013;114(3):589-98.

Wang L, Liu R, Chen GY, Zhou P, Li C, Ye P, Bassetti M, Zheng X, Wu W, Zhang Y, Zheng P, Liu Y. Intracellular CD24 Disrupts ARF-NPM Interaction and Enables Mutational and Viral Oncogene-mediated p53 Inactivation. Nature Communication, 2014 in press.  
http//wwwncbinlmnihgov/pubmed?term=lizhong%20 

Keywords
Tumor Suppressor Gene, Tumor Development and Progression, Cancer Genetics