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Faculty Detail     Name JUSTIN ROTH   Campus Address CHB 140 Zip 0011 Phone 205-276-5063 E-mail jcroth@uab.edu Other websites

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Pediatrics   Ped - Infectious Disease Instructor Center  Comprehensive Cancer Center  Comprehensive Cancer Center Instructor

Biographical Sketch  I received my Ph.D. in the Molecular Virology Program at Case Western Reserve University under Stanton L. Gerson, M.D. My postdoctoral fellowship was with David Curiel in the Gene Therapy Center at the University of Alabama at Birmingham.

Research/Clinical Interest Title Description Viral vectors offer significant therapeutic potential for a number of diseases. However, effective delivery or targeting of these vectors to specific diseased sites is needed before their true potential can be realized. Our lab is evaluating the use of different cell populations to deliver viruses to sites of pathology, and whether the cells can be manipulated to enhance the specificity of delivery. Prior work has focused on the development of lentiviral and adenoviral vectors, and we are now applying these strategies towards the development of oncolytic herpes viruses (oHSV) for glioma. Specifically, we are working to develop oHSV with improved glioma-specific replication that are also armed to express immunomodulatory factors to enhance efficacy.

Selected Publications  Publication PUBMEDID J. C. Roth, M Ismail, JS Reese, KT Lingas, G Ferrari, and SL Gerson. Cotransduction with MGMT and Ubiquitous or Erythroid-Specific GFP Lentiviruses Allows Enrichment of Dual-Positive Hematopoietic Progenitor Cells In Vivo. Epub 2012 July 18, Volume 2012, Article ID 212586.  22888445  MO Alberti*, J. C. Roth*, M Ismail, Y Tsuruta, E Abraham, L Pereboeva, SL Gerson, and DT Curiel. (2012) Derivation of a Myeloid Cell-binding Adenovirus for Gene Therapy of Inflammation. PLoS One. 2012;7(5):e37812. Epub 2012 May 18.  22624065  Paul, C. P., M. Everts, P. Dent, P. B. Fisher, I. V. Ulasov, M. S. Lesniak, M. A. Stoff-Khalili, J. C. Roth, J. N. Glasgow, M. A. Preuss, C. M. Dirven, M. L. Lamfers, G. P. Siegal, Z. B. Zhu and D. T. Curiel (2007). "Characterization of Infectivity of Knob-Modified Adenoviral Vectors in Glioma." Cancer Biol Ther 7(3).  18756624  J. C. Roth, D. T. Curiel and L. Pereboeva (2008). "Cell vehicle targeting strategies." Gene Ther 15(10): 716-29.  18369326  Pereboeva, L., S. Komarova, J. C. Roth, S. Ponnazhagan and D. T. Curiel (2007). "Targeting EGFR with metabolically biotinylated fiber-mosaic adenovirus." Gene Ther 14(8): 627-37. PMCID: PMC2203207  17251987  M.O. Alberti, J.S. Deshane, D.D. Chaplin, L. Pereboeva, D.T. Curiel, and J.C. Roth. A myeloid cell-binding adenovirus efficiently targets gene transfer to the lung and escapes liver tropism. Gene Therapy, October, 2012    L. Pereboeva. and J. C. Roth (2007). Mesenchymal stem cells as vehicles for delivering therapeutics and oncolytic viruses. In: Progress in Gene Therapy, Vol. 3, WSPC, Singapore, p393-443.    J. C. Roth, S. L. Gerson,. (2007) Drug Resistance Gene Transfer into Hematopoietic Stem Cells. IN Hunt, KK, Vorburger, SA., and Swisher, SG. (Eds.) Gene therapy for cancer. 1st ed. Totowa, N.J., Humana Press.

Keywords HSV-1,lentivirus, cancer gene therapy, stem cells

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