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Faculty Detail    
Name SUMANT SINGH CHUGH
 
Campus Address THT 611L Zip 0007
Phone 205-996-9641
E-mail chugh@uab.edu
Other websites http://www.uab.edu/medicine/nephrology/research/basic-research/gdtl
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Medicine  Med - Nephrology Professor
Center  Medicine  Comprehensive Diabetes Ctr Professor
Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Professor
Center  Medicine  Nephrology Res & Trng Ctr Professor

Biographical Sketch 
Dr. Sumant Singh Chugh is Principal Investigator of the Glomerular Disease Therapeutics Laboratory, and Associate Program Director for Research in the Division of Nephrology. He is widely credited for having described the molecular basis of human Minimal Change Disease, a form of nephrotic syndrome most commonly seen in children. Dr. Chugh graduated from Christian Medical College Ludhiana, India, and completed Internal Medicine residencies at the Postgraduate Institute Chandigarh, India, and Newton Wellesley Hospital, Newton MA. He completed his Nephrology Fellowship from Boston University, and joined as Assistant Professor of Medicine at Northwestern University Feinberg School of Medicine in September 2000. In September 2007, he joined UAB as Associate Professor of Medicine. Dr. Chugh was promoted to Professor of Medicine in 2011, and was elected to the American Society of Clinical Investigation in 2012. He was unanimously selected to receive the Max Cooper Award for Excellence in Research in 2012, and is a prior recipient of the ASN Carl W. Gottschalk Research Scholar Award (2002), the NKF Young Investigator Grant Award (2004) and the Faculty Recognition Award (2004). Dr. Chugh has been a NIH funded investigator since 2001.

Society Memberships
Organization Name Position Held Org Link
American Society of Biochemistry and Molecular Biology  Member   
American Society of Clinical Investigation  Member   
American Society of Nephrology   Fellow   
Asian Pacific Society of Nephrology  Member   
Indian Society of Nephrology  Member   
National Kidney Foundation  Member   
Southern Society of Clinical Investigation  Member   

Research/Clinical Interest
Title
Mechanism based treatment of nephrotic syndrome
Description
Over the past decade, our laboratory has focused on investigating mechanisms of proteinuria, with the intent of developing mechanism based therapy. Some of the projects include identifying a molecular basis for slit diaphragm permeability (JCI 2003), identification and characterization of the role of ZHX transcriptional factors in podocyte gene expression (JBC 2006), identification of glucocorticoid-sensitive genes in the podocyte (KI 2007), dissecting changes in podocyte gene expression during the development of glomerular capillary loop collapse (KI 2007), identification of podocyte secreted Angiopoietin-like 4 (Angptl4) as a major molecular player in human and experimental Minimal Change Disease (Nature Medicine 2010), and establishment of circulating Angptl4 as the molecular link between proteinuria and hypertriglyceridemia in nephrotic syndrome (Nature Medicine 2013). Current therapeutic strategies under development are based on the manipulation of podocyte expression of ZHX transcriptional factors, improving sialylation of podocyte secreted hyposialylated Angptl4 to reduce proteinuria in MCD and diabetic nephropathy, and using mutant forms of human Angptl4 to treat proteinuria and nephrotic syndrome. We are also actively involved in determining factors in the circulation that modulate human glomerular disease. Instead of looking for individual circulating factors, we are engaged in indentifying a circulating glomerulophilic proteome (CGP) using a multidimensional approach.

Selected Publications 
Publication PUBMEDID
Wiggins RC, Alpers CE, Holzman LB, He JC, Salant DJ, Chugh SS, Natarajan R, Trachtman H, Brasile L, Star RA, Rys-Sikora KE, Moxey-Mims M, and Flessner MF. Glomerular disease: seeing beyond pathology. Clin J Am Soc Nephrol 2014, published online April 3 2014  24700796 
Chugh SS, Macé C, Clement LC, Del Nogal Avila M and Marshall CM. Angiopoietin-like 4 based therapeutics for proteinuria and kidney disease. Front. Pharmacol. 2014;5:1-8.  24611049 
Clement LC*, Macé C* (*equal contributors), Avila-Casado C, Joles JA, Kersten S and Chugh SS. Circulating Angiopoietin-like 4 links proteinuria with hypertriglyceridemia in nephrotic syndrome. Nat Med 2014;20(1):37-46. published online December 8th, 2013. doi:10.1038/nm.3396.  24317117 
Chugh SS and Clement LC. Telomerase at the center of collapsing glomerulopathy. Nat Med 2012;18:26-27.  22227662 
Chugh SS, Clement LC, Macé C. New insights into human minimal change disease: Lessons from animal models. Am J Kid Dis 2012;59:284-292.Published online October 4, 2011.  21974967 
Avila-Casado C, Fortoul TI, Chugh SS. HIV-associated nephropathy: experimental models. Contrib Nephrol 2011,169:270-285.  21252526 
Clement LC, Avila-Casado C, Macé C, Soria E, Bakker WW, Kersten S and Chugh SS. Podocyte – secreted Angiopoietin-like-4 mediates proteinuria in glucocorticoid-sensitive nephrotic syndrome. Nat Med. 2011;17:117-122. published online Dec 12 2010  21151138 
Bell EK, Chugh SS, Cook WJ. A case of infection-associated antiproteinase-3-negative cytoplasmic antineutrophil cytoplasmic antibody pauci-immune focal necrotizing glomerulonephritis. Nephrol Dial Transplant. 2010 Sep;25(9):3119-23.  20566570 
Chugh SS. Transcriptional regulation of podocyte disease. Transl Res 2007;149:237-242.   17466922 
Clement L, Liu G, Perez-Torres I, Kanwar YS, Avila-Casado C and Chugh SS. Early changes in gene expression that influence the course of primary glomerular disease. Kidney Int. 2007;72:337-347.  17457373 
Kanwar YS, Danesh FR, Chugh SS. Contribution of Proteoglycans Towards the Integrated Functions of Renal Glomerular Capillaries. A Historical Perspective. Am J Pathol. 2007,171:9-13.  17591948 
Kanwar YS, Danesh FR, Chugh SS. Chimerism of the renal glomerulus revisited. J Am Soc Nephrol, 2007;18:2215-7.  17625114 
Liu G, Clement L, Kanwar YS, Avila-Casado C and Chugh SS. ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome. J Biol Chem 2006, 281;39681-39692.  17056598 
Nayak B, Xie P, Akagi S, Lin S, Wada J, Thakur A, Danesh FR, Chugh SS, Kanwar YS. Modulation of renal specific oxido-reductase expression by diverse mechanisms in high glucose ambience. Proc Nat Acad Sci 2005 Dec 13;102(50):17952-7  16330753 
Schafernak KT, Chugh SS, Kanwar YS. Co-existent crescentic glomerulonephritis and renal amyloidosis. J Nephrol. 18(5):616-22, 2005.  16299691 
Kanwar YS, Akagi S, Nayak b, Lin S, Wada J, Xie P, Thakur A, Chugh SS, Danesh FR. Renal-specific oxidoreductase biphasic expression under high glucose ambience during fetal Vs. neonatal development. Kidney Int 2005;68:1670-1683.  16164644 
Kanwar YS, Akagi S, Lin S, Nayak B, Xie P, Wada J, Chugh SS, Danesh FR. Cell Biology of Diabetic Kidney Disease. Nephron Exp Nephrol. 2005 Aug 8;101(3):e100-e110  16088221 
Kanwar YS, Nayak B, Lin S, Akagi S, Xie P, Wada J, Chugh SS, Danesh FR. Hyperglycemia: its imminent effects on mammalian nephrogenesis. Pediatr Nephrol. 2005 Jul;20(7):858-66.  15875217 
Kanwar YS, Wada J, Lin S, Danesh FR, Chugh SS, Yang Q, Banerjee T, Lomasney JW. Update on extracellular matrix, its receptors and cell adhesion molecules in mammalian nephrogenesis. Am J Physiol 2004;286:F202-F215  14707006 
Chugh SS, Wallner EI, Kanwar YS. Impact of hyperglycemia on the developing kidney. Semin Nephrol 2003;23:583-592  14631566 
Chugh SS, Kaw B, Kanwar YS. Molecular structure-function relationship in the slit diaphragm. Semin Nephrol 2003;23:544-555  14631562 
Liu G, Kaw B, Kurfis J, Rahmanuddin S, Kanwar YS, Chugh SS. Neph1 and nephrin interaction in the slit diaphragm is an important determinant of glomerular permeability. J Clin Invest 2003;112:209-221.  12865409 
Sun L, Pan X, Wada J, Haas CS, Wuthrich RP, Danesh FR, Chugh SS, Kanwar YS. Isolation and functional analysis of mouse UbA52 gene and its relevance to diabetic nephropathy. J Biol Chem 2002;277:29953-29962  12171997 
Lin S, Chugh S, Pan X, Wallner EI, Wada J, Kanwar YS. Identification of up-regulated Ras-like GTPase, Rap1b, by suppression subtractive hybridization. Kidney Int 2001;60:2129-2141.  11737587 
Chugh S, Yuan H, Haydar S, Mittal V, Topham P, Kalluri R, Salant DJ. Aminopeptidase A: A nephritogenic target antigen of nephrotoxic serum. Kidney Int 2001;59:601-613.  11168941 
Chugh KS, Jha V, Chugh S. Economics of dialysis and transplantation in the developing world. Transplant Proc 1999;8:3275-3277.  10616473 
Topham PS, Kawachi H, Haydar SA, Chugh S, Addona T, Holzman LB, Shia M, Shimizu F, Salant DJ. Nephritogenic monoclonal antibody 5-1-6 is directed against the extracellular domain of rat nephrin. J Clin Invest 1999;104:1559-1566.  10587519 
Chugh S, Yager H. End stage renal disease following treatment with lithium. J Clin Psychopharmacol 1997;17:495-497.  9408819 
Chugh S, Bird R, Alexander EA. Ritonavir and renal failure. N Engl J Med 1997;336:138.  8992345 
Rubenstein JN, Eggener SE, Pins MR, Rosner K, Chugh S, Campbell SC. Juxtaglomerular apparatus tumor: A rare, surgically correctable cause of hypertension. Reviews in Urology, 4(4), 192-195, 2002.   
Topham PS, Chugh S, Salant DJ. New insights into the pathogenesis of proteinuria. Am J Kid Dis 2000;36:214-219.   
Jha V, Chugh S, Chugh KS. Infections in dialysis and transplant patients in the tropical countries. Kidney Int 2000;57:S85-S93.   
Chugh S, Yager H. Management of diabetes insipidus. In Rakel RE (editor) Conn’s current therapy - year 2000 edition. Philadelphia, W.B. Saunders.   
Chugh S, Clark B, Yager H. Principles of fluid / electrolyte balance and renal disorders in the older patient. in Gallo, J.J. (editor) Reichel’s Care of the Elderly: Clinical Aspects of Aging. Fifth edition 1999. Baltimore, Williams and Wilkins.   
Jha V, Chugh KS, Chugh S. Continuous ambulatory peritoneal dialysis. In Das, AK (editor) Medicine Update 1998;8:422-429. Bombay, Association of Physicians of India.   
Chugh KS, Jha V, Chugh S. Tropical acute renal failure. Kidney 1998;7:43-47.   
Jha V, Chugh KS, Chugh S. Acute renal failure. In Bansal, BC (editor) Postgraduate Medicine 1997;11:360-365. Bombay, Association of Physicians of India.   
Jha V, Chugh KS, Chugh S. Renal artery stenosis-The year 2000 and beyond. In Munjal, YP (editor) Medicine Update 1997;7:533-537. Bombay, Association of Physicians of India.   
Chugh S, Dash RJ, Sialy R, Sakhuja V. Relationship of insulin resistance with hypertension and body habitus in North Indian subjects with a normal glucose tolerance. Indian J Nephrol 1996;6:153-161.   
Chugh S, Dash RJ. Insulin resistance and essential hypertension. (editorial) Indian J Nephrol 1995;5:27-32.   
Chugh S, Dilawari JB, Sawhney IMS, Dang N, Radotra BD, Chawla YK. Polymyositis associated with ulcerative colitis. Gut 1993;34:567-569.  8491410 
Jha V, Chugh S, Gupta KL, Joshi K, Sakhuja V. Renal amyloidosis in juvenile rheumatoid arthritis. J Assoc Phys Ind 1993;41:117-119.  8335603 

Keywords
nephrotic syndrome, proteinuria, minimal change disease, diabetic nephropathy, podocyte