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Faculty Detail    
Name RAKESH PRAVINCHANDRA PATEL
 
Campus Address BMR2 532 Zip 2182
Phone 205-975-9225
E-mail rakeshp@uab.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Pathology   Molecular & Cellular Pathology Professor
Secondary  Anesthesiology   Anesthesiology Chair Office Associate Professor
Secondary  Environmental Health Sciences  Environmental Health Sciences Assistant Professor
Center  Center for Aging  COMPREHENSIVE CTR FOR HEALTHY AGING Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  Medicine  Comprehensive Diabetes Ctr Professor
Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Professor
Center  Cell, Developmntl, & Integrative Biology  Ctr for Exercise Medicine Professor
Center  Medicine  Ctr Cardiovasc Bio Professor
Center  Medicine  Nephrology Res & Trng Ctr Professor
Center  Nutrition Sciences   Nutrition Obesity Res Ctr (NORC) Professor

Graduate Biomedical Sciences Affiliations
Biochemistry and Structural Biology 
Cancer Biology 
Integrative Biomedical Sciences 
Medical Scientist Training Program 
Molecular and Cellular Pathology Program 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Dr Patel graduated from the University of Essex, UK, where he also obtained his Ph.D in 1996. He then joined the Department of Pathology, University of Alabama at Birmingham (UAB) as a post-doctoral fellow, where he is currently Professor and director of the HHHMI Med to Grad program and Department of Pathology Graduate program. Dr Patel’s research centers on understanding the mechanisms that regulate acute and chronic inflammation with a goal of using these insights to develop and test therapeutics targeted to prevent or limit inflammatory injury. Current areas of research include i) investigating how heme proteins interface with reactive oxygen and nitrogen species (including nitric oxide and nitrite) to modulate transfusion toxicity, acute lung injury and ischemia reperfusion injury and ii) understanding how post-translational regulation of protein by N-glycans regulate endothelial cell reactivity and monocyte adhesion in the context of atherosclerosis.

Society Memberships
Organization Name Position Held Org Link
American Physiological Society     
American Society of Biochemistry and Molecular Biology     
Biochemical Society     
International Society for Free Radical Research     
Society for Free Radical Biology and Medicine     
Society for Glycobiology     

Research/Clinical Interest
Title
Modulation of Inflammation by Reactive Species and N-glycans
Description
Inflammation is recognized as a key component in the development of both acute and chronic diseases affecting all organ systems. Reactive species (also referred to as free radicals or reactive oxygen, nitrogen or chlorine species) have been identified as important mediators in inflammation with roles in both initiating and preventing disease. We are interested in understanding what regulates the reactivity and function of reactive species and pursue this aim in the following contexts 1) interactions of nitric oxide and nitrite with red blood cells during normal physiological conditions, during red cell storage and inflammation associated with Sepsis, ischemia-reperfusion and transfusion –related injury. Specifically, we are pursuing the idea that hemoglobin regulates blood flow and acts as a switch that controls the anti- and pro-inflammatory effects of nitric oxide 2) evaluating mechanisms by which inhaled toxicants (specifically Chlorine gas) impairs endogenous nitric oxide signaling and developing nitric oxide based therapeutic strategies to limit chlorine gas induced pulmonary toxicity, 3) anti-inflammatory effects of dietary antioxidants. Specifically, consumption of isoflavones is associated with decreased incidence of the chronic inflammatory disease, atherosclerosis. We are investigating the mechanisms of these effects and focusing on how synergistic interactions between components in the diet, and physical forces associated with blood flow modulate endothelial surface N-glycans which in turn control monocyte adhesion during inflammation, 4) Finally, we are translating insights gained from these studies into the clinic by evaluating NO-based therapeutics in inflammatory diseases and specifically organ transplantation.

Selected Publications 
Publication PUBMEDID
Vitturi DA, Sun CW, Harper VM, Thrash-Williams B, Cantu-Medellin N, Chacko BK, Peng N, Dai Y, Wyss JM, Townes T, Patel RP (2012) Free Rad Biol Med Antioxidant functions for the hemoglobin β93 cysteine residue in erythrocytes and in the vascular compartment in vivo. [Epub ahead of print]

 
23159546 
El-Ferzli GT, Dreher M, Patel RP, Ambalavanan N.(2012) ABO blood group is associated with response to inhaled nitric oxide in neonates with respiratory failure. PLos One 7(9)



 
22984626 
Samal AA, Honavar J, Brandon A, Bradley KM, Doran S, Liu Y, Dunaway C, Steele C, Postlethwait EM, Squadrito GL, Fanucchi MV, Matalon S, Patel RP.(2012) Administration of nitrite after chlorine gas exposure prevents lung injury: effect of administration modality. Free Rad Biol Med 53(7):1431-9
 
22917977 
Scott DW, Chen J, Chacko BK, Traylor JG Jr, Orr AW, Patel RP.(2012). Role of endothelial N-glycan mannose residues in monocyte recruitment during atherogenesis. ATVB 32(8) Epub Ahead of print



 
22723438 
Stapley R, Owusu BY, Brandon A, Cusick M, Rodriguez C, Marques MB, Kerby JD, Barnum SR, Weinberg JA, Lancaster JR Jr, Patel RP. (2012) Erythrocyte storage increases rates of NO and nitrite scavenging: implications for transfusion-related toxicity.Biochem J. 446(3);499-508



 
22720637 
Owusu BY, Stapley R, Patel RP.(2012)Nitric oxide formation versus scavenging: the red blood cell balancing act.
J. Physiol. 590(Pt20):4993-5000


 
22687616 
Greenway FL, Predmore BL, Flanagan DR, Giordano T, Qiu Y, Brandon A, Lefer DJ, Patel RP, Kevil CG.(2012)Single-dose pharmacokinetics of different oral sodium nitrite formulations in diabetes patients.Diabetes Technol Ther. 2012 Jul;14(7):552-60



 
22468627 
Weinberg JA, Barnum SR, Patel RP.(2012)Red blood cell age and potentiation of transfusion-related pathology in trauma patients.Transfusion. 2011 Apr;51(4):867-73.



 
21496048 
Christopher G Kevil and Rakesh P Patel (2010) S-nitrosothiol biology and Therapeutic potential in metabolic disease. Current Opinion in Investigational Drugs. 10: 1127-34   20872315 
T. Scott Isbell, Chiao-Wang Sun, Li-Chen Wu, Xinjun Teng, Dario A. Vitturi, Billy G Branch, Christopher G Kevi, Namasivayam Ambalavanan Lisa Schwiebert, Jinxiang Ren, Kevin M. Pawlik, Matthew B. Renfrow, Rakesh P. Patel*, Tim M. Townes*. (2008) Role of SNO-Hemoglobin in Normal Development and Physiology. Nature Medicine 14(7); 773
* Co-senior author
 
18516054 
Shiva S, Rassaf T, Patel RP, Gladwn MT (2010) The detection of the nitrite reductase and NO-generating properties of haemoglobin by mitochondrial inhibition. Cardiovascular Res. 89: 566-573  18508974  
Bennavides GA, Squadrito GL, Mills RW, Patel HD, Isbell TS, Patel RP, Darley-Usmar VM, Doeller JE, Kraus DW Hydrogen sulfide mediates the vasoactivity of garlic. Proc Natl Acad Sci U S A. 2007. 104; 17977-82
 
17951430 
Kelpke SS, Chen B, Bradley KM, Teng X, Chumley P, Moore B, Head H, Viera L, Thompson JA, Crossman DK, Bray MS, Eckhoff DE, Agarwal A, Patel RP (2012). Sodium nitrite therapy protects against brain death induced kidney injury and improves post-transplantation function. Kidney International. 82(3):304-13  17947960 
John D Lang Jr, Xinjun Teng, Phillip Chumley, Jack H Crawford, T. Scott Isbell, Balu K Chacko, Yuliang Liu, Nirag Jhala, D. Ralph Crowe, Alvin B Smith, Richard C Cross, Luc Frenette, Mike Fallon , Eric E Kelley, Diana W Wilhite, Cheryl R Hall, Grier P Page, J Steven Bynon, Devin E Eckhoff and Rakesh P. Patel (2007) Preemptive Administration of Inhaled Nitric Oxide Accelerates Restoration of Liver Function in Adults Following Orthotopic Liver Transplantation. J Clin Inv. 4;117(9):2583-2591   17717604 
Chacko BK, Scott DW, Chandler RT, Patel RP (2011). Endothelial surface N-glycans mediate leukocyte adhesion and are targets for the anti-inflammatory effects of PPAR ligands. J Biol. Chem. 286(44):38738-47  17237310 
Jack H Crawford, James Huang, T. Scott Isbell, Sruti Shiva, Balu K Chacko, Alan Schechter, Victor M Darley-Usmar, Jeffrey D Kerby, John D Lang Jr, David Krauss, Chien Ho, Mark T Gladwin, Rakesh P Patel (2006) Hypoxia, Red Blood Cells and Nitrite Regulate NO-dependent Hypoxic Vasodilatation. Blood 107, 566-574  16195332 
D. Vitturi, X Teng, JC Toledo, S Matalon, JR Lancaster Jr, RP Patel (2009) Effects of Hemoglobin Fractional Saturation on Nitrite transport in Red Blood Cells: Evidence for Hypoxic Regulation of Nitrite Export. Am J Physiol In Press  2685350 
Cantu-Medellin N, Vitturi DA, Rodriguez C, Murphy S, Dorman S, Shiva S, Zhou Y, Jia Y, Palmer AF, Patel RP (2011). Effects of T-state and R-state stabilization on deoxyhemoglobin-nitrite reactions and stimulation of nitric oxide signaling. Nitric Oxide: Biology and Chemistry. In Press  2396555 
C. Rodriguez, D. Vitturi, J He, M Vandromme, A Brandon, A Hutchings, LW Rue III, JD Kerby, RP Patel (2009) Sodium nitrite therapy attenuates hypertensive effects of HBOC-201 via a nitrite-reductase activity. Biochem J 422(3), 423-432   150230 
Weinberg JA, MacLennan PA, Vandromme-Cusick MJ, Angotti JM, Magnotti LJ, Kerby JD, Rue LW III, Barnum SR, Patel RP (2012). Microvascular response to red blood cell transfusion in trauma patients. Shock 37:276-281   
Yadav AK, Doran SF, Samal AA, Sharma R, Vedagiri K, Postlethwait EM, Squadrito GL, Fanucchi MV, Roberts LJ 2nd, Patel RP*, Matalon S* (2010) Mitigation of Chlorine Gas Lung Injury in rats by post exposure administration of sodium nitrite. Am J Physiol Lung Cell Mol Physiol. 2011 Mar;300(3):L362-9.*Co-senior authors   
Honavar J, Samal AA, Bradley KM, Brandon A, Balanay J, Squadrito GL, Mohankumar K, Maheshwari A, Postlethwait EM, Matalon S, Patel RP (2010). Chlorine gas exposure causes systemic endothelial dysfunction by inhibiting eNOS-dependent signaling. Am J Respir Cell Mol Biol. 2011 Aug;45(2):419-25.    
Stéphane P Dufour, Rakesh P Patel, Angela Brandon, Xinjun Teng, James Pearson, Horace Barker, Leena Ali, Ada HY Yuen, Ryszard T Smolenski, José González-Alonso (2010) Erythrocyte dependent regulation of human skeletal muscle blood flow: Role of varied oxyhemoglobin and exercise on nitrite, s-nitrosohemoglobin and ATP. Am J. Phys-Heart and Circ Phys. 299: H1936   
Shoman ME, DuMond JF, Isbell TS, Crawford JH, Brandon A, Honavar J, Vitturi DA, White CR, Patel RP, Bruce King S (2011). Acyloxy Nitroso Compounds as Nitroxyl (HNO) Donors: Kinetics, Reactions with thiols, and vasodilation properties. J Med Chem. 2011 Feb 24;54(4):1059-70   

Keywords
vascular, hemoglobin, red cells, Inflammation, isoflavones, Nitric oxide, nitrite, N-glycan