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Faculty Detail     Name PETER EDWARD PREVELIGE, JR   Campus Address BBRB 416 Zip 2170 Phone 205-975-5327 E-mail prevelig@uab.edu Other websites http://www.preveligelab.org

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Microbiology  Microbiology Professor Secondary  Biochemistry & Molecular Genetics  Biochemistry & Molecular Genetics Associate Professor Center  Arthritis & Musculoskeletal Diseases Center  Arthritis & Musculoskeletal Diseases Center Professor Center  Center for AIDS Research  Center for AIDS Research Professor Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor

Graduate Biomedical Sciences Affiliations Biochemistry and Molecular Genetics Program  Biochemistry and Structural Biology  Cell, Molecular, & Developmental Biology  Cellular and Molecular Biology Program  Hughes Med-Grad Fellowship Program  Medical Scientist Training Program  Microbiology

Biographical Sketch  Peter E. Prevelige (b. 1956), Professor of Microbiology, completed undergraduate studies in biology at Lehigh University. His graduate studies were done at Brandeis University (Ph.D., Biochemistry, 1985) on histone structure with Dr. G.D. Fasman. His postdoctoral work, on virus capsid assembly, was done at MIT under the direction of Dr. J. King. He held the position of Staff Scientist at Boston Biomedical Research Institute from 1992-1995 and joined the UAB faculty in 1995.

Society Memberships Organization Name Position Held Org Link ASBMB      ASM      ASV      Biophysical Society      Materials Research Society      Protein Society

Research/Clinical Interest Title Structural Biology of Viral Assembly and Infection Description The assembly of protein subunits into polymeric supramolecular structures is controlled both temporally and positionally. Control is achieved through the use of highly specific protein/protein recognition events, and well-defined assembly pathways. The manner in which this information is encoded in the protein subunits is not well understood, despite the fact that interfering with these pathways holds promise therapeutically for indications as diverse as viral & bacterial infections, alzheimers disease, and neoplasia. We take an interdisciplinary approach employing an array of biochemical, biophysical, genetic, and structural tools to study these processes. Two viral systems with distinctive assembly pathways are under active investigation. One system, the Salmonella bacteriophage P22 which assembles into well defined non-enveloped stable icosahedral capsids typifies tightly controlled assembly pathways while the other, HIV which forms fragile polymorphous enveloped capsids suggests more flexibility in assembly. Comparison of these systems will illuminate different biological strategies for control of capsid assembly, and will ultimately lead to novel antiviral approaches which directly target capsid assembly.

Selected Publications  Publication PUBMEDID Directed self-assembly of CdS quantum dots on bacteriophage P22 coat protein templates. Kale A, Bao Y, Zhou Z, Prevelige PE, Gupta A. Nanotechnology. 2013 Feb 1;24(4):045603. doi: 10.1088/0957-4484/24/4/045603. Epub 2013 Jan 7.  23296127  Coconfinement of Fluorescent Proteins: Spatially Enforced Communication of GFP and mCherry Encapsulated within the P22 Capsid.O'Neil A, Prevelige PE, Basu G, Douglas T.Biomacromolecules. 2012 Dec 10;13(12):3902-7. doi: 10.1021/bm301347x. Epub 2012 Nov 9.  23121071   Use of the interior cavity of the P22 capsid for site-specific initiation of atom-transfer radical polymerization with high-density cargo loading. Lucon J, Qazi S, Uchida M, Bedwell GJ, LaFrance B, Prevelige PE Jr, Douglas T.Nat Chem. 2012 Oct;4(10):781-8. doi: 10.1038/nchem.1442. Epub 2012 Aug 26.  23000990  P22 viral capsids as nanocomposite high-relaxivity MRI contrast agents. Qazi S, Liepold LO, Abedin MJ, Johnson B, Prevelige P, Frank JA, Douglas T.Mol Pharm. 2013 Jan 7;10(1):11-7. doi: 10.1021/mp300208g. Epub 2012 Jul 16  22656692  Nanoreactors by programmed enzyme encapsulation inside the capsid of the bacteriophage P22. Patterson DP, Prevelige PE, Douglas T. ACS Nano. 2012 Jun 26;6(6):5000-9. doi: 10.1021/nn300545z. Epub 2012 May 31.  22624576  A retroviral chimeric capsid protein reveals the role of the N-terminal β-hairpin in mature core assembly. Cortines JR, Monroe EB, Kang S, Prevelige PE Jr. J Mol Biol. 2011 Jul 22;410(4):641-52. doi: 10.1016/j.jmb.2011.03.052.  21762805  Three-dimensional structure of a viral genome-delivery portal vertex. Olia AS, Prevelige PE Jr, Johnson JE, Cingolani G. Nat Struct Mol Biol. 2011 May;18(5):597-603. doi: 10.1038/nsmb.2023. Epub 2011 Apr 17.  21499245  Peering down the barrel of a bacteriophage portal: the genome packaging and release valve in p22. Tang J, Lander GC, Olia AS, Li R, Casjens S, Prevelige P Jr, Cingolani G, Baker TS, Johnson JE. Structure. 2011 Apr 13;19(4):496-502. doi: 10.1016/j.str.2011.02.01  21439834  Hydrogen/deuterium exchange analysis of HIV-1 capsid assembly and maturation. Monroe EB, Kang S, Kyere SK, Li R, Prevelige PE Jr.Structure. 2010 Nov 10;18(11):1483-91. doi: 10.1016/j.str.2010.08.016.  21070947  Myristate exposure in the human immunodeficiency virus type 1 matrix protein is modulated by pH. Fledderman EL, Fujii K, Ghanam RH, Waki K, Prevelige PE, Freed EO, Saad JS. Biochemistry. 2010 Nov 9;49(44):9551-62. doi: 10.1021/bi101245j.  20886905

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