Back to Main

Faculty Detail     Name STEVEN POGWIZD   Campus Address VH B140 Zip 0019 Phone 205-975-4710 E-mail spogwizd@uab.edu Other websites

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Medicine  Med - Cardiovascular Disease Professor Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Professor Center  Arthritis & Musculoskeletal Diseases Center  Arthritis & Musculoskeletal Diseases Center Professor Center  Cell, Developmntl, & Integrative Biology  Ctr for Exercise Medicine Professor

Graduate Biomedical Sciences Affiliations Medical Scientist Training Program

Biographical Sketch  Steven M. Pogwizd was born in Chicago, Illinois in October 1955. He received a BA degree in chemistry from the University of Chicago in 1977 (Magna cum laude) and a MD from Washington University in 1981. After he completed his residency at Michael Reese Hospital, Chicago in 1984, he was a research fellow, clinical fellow, and attending physician at Barnes Hospital, Washington University School of Medicine in St. Louis from 1984-1998. He served as Assistant Professor of Medicine, Washington University, from 1989-1998. From 1998-2008 he served as Associate Professor of Medicine and then subsequently promoted to Professor, University of Illinois at Chicago. He joined the faculty of UAB in January 2008 as Professor of Medicine, Biomedical Engineering and Physiology & Biophysics. He is Associate Director of Research in the Division of Cardiovascular Disease. He was named the Featheringill Endowed Professor in Cardiac Arrhythmia Research.

Society Memberships Organization Name Position Held Org Link American Heart Association      Biophysical Society      Cardiac Electrophysiologic Society      Heart Rhythm Society      International Society for Heart Research

Research/Clinical Interest Title Description The mission of the Pogwizd lab is to define the electrophysiological and biochemical mechanisms underlying lethal arrhythmias in the setting of heart failure (HF). My interest in the mechanisms of ventricular tachycardia (VT) and ventricular fibrillation (VF) arose from my 3-dimensional cardiac mapping studies of VT and VF in the setting of myocardial ischemia (Pogwizd & Corr, Circulation Circ Res 1987;61,352-371, Circulation 1987;76:404-426, and Circ Res 1990;66:672-695). My work evolved to the area of HF with the development of a novel arrhythmogenic rabbit model of HF (Pogwizd, Circulation 1995;92:1034-1048). During a nearly one-year sabbatical in the laboratories of Drs. Donald Bers and Alan Samarel at Loyola University (1997-1998), I learned fluorescent imaging of cellular Ca and Na, patch clamping and molecular biology approaches that I have applied to my studies in experimental models of HF and in the failing human heart (Pogwizd et al, Circ Res 1999;85:1009-1019 and Circ Res 2001;88:1159-1167). More recently my work has expanded to the role of connexins, their phosphorylation and dephosphorylation (Ai & Pogwizd, Circ Res 2005;96:54-63: Ai et al, Card Res, in press 2009); adenoviral gene transfer (Ziolo et al, Circ Res 2005;96:815-817) and three-dimensional electrocardiographic imaging (Am J Physiol 2005;289:H2724-2732) along with continued studies of Ca handling, adrenergic stimulation and ion channel alterations in the failing heart (Circ Res. 2005;97:1314-1322, Circ Res 2007;101(8):802-810, deSantiago et al, Circ Res 2008;102(6):695-702, and Circ Res 2008;102:1389-1397).

Selected Publications  Publication PUBMEDID Li L, Jin Q, Dosdall DJ, Huang J, Pogwizd SM and Ideker RE. Activation becomes highly organized during long-duration ventricular fibrillation in canine hearts. Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H2046-53.   20382862   Curran J, Brown KH, Santiago DJ, Pogwizd SM, Bers DM and Shannon TR. Spontaneous Ca waves in ventricular myocytes from failing hearts depend on Ca(2+)-calmodulin-dependent protein kinase II. J Mol Cell Cardiol. 2010 Jul;49(1):25-32.   20353795   Rinne A, Kapur N, Molkentin JD, Pogwizd SM, Bers DM, Banach K and Blatter LA. Isoform- and tissue-specific regulation of the Ca(2+)-sensitive transcription factor NFAT in cardiac myocytes and heart failure. Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H2001-9.   20304816  Han C, Liu C, Pogwizd SM and He B. Noninvasive three-dimensional cardiac activation imaging on a rabbit model. Conf Proc IEEE Eng Med Biol Soc. 2009;2009:3271-3.   19964067  Ai X, Zhao W and Pogwizd SM. Connexin43 knockdown or overexpression modulates cell coupling in control and failing rabbit left ventricular myocytes. Cardiovasc Res. 2010 Mar 1;85(4):751-62.  19880431   Ideker RE, Rogers JM, Fast V, Li L, Kay GN and Pogwizd SM. Can mapping differentiate microreentry from a focus in the ventricle? Heart Rhythm. 2009 Nov;6(11):1666-9.   19793684  Ideker RE, Kong W and Pogwizd SM. Purkinje fibers and arrhythmias. Pacing Clin Electrophysiol. 2009 Mar;32(3):283-5.   19272054  Han C, Liu Z, Zhang X, Pogwizd SM and He B. Noninvasive three-dimensional cardiac activation imaging from body surface potential maps: a computational and experimental study on a rabbit model. IEEE Trans Med Imaging. 2008 Nov;27(11):1622-30. PMC2701977   18955177  Desantiago J, Ai X, Islam M, Acuna G, Ziolo MT, Bers DM and Pogwizd SM. Arrhythmogenic effects of beta2-adrenergic stimulation in the failing heart are attributable to enhanced sarcoplasmic reticulum Ca load. Circ Res. 2008 Jun 6;102(11):1389-97. PMC2585979   18467626  Attin M, Ideker RE and Pogwizd SM. Mechanistic insights into ventricular arrhythmias from mapping studies in humans.Heart Rhythm. 2008 Jun;5(6 Suppl):S53-8. Epub 2008 Mar 27. Review. No abstract available. Erratum in: Heart Rhythm. 2008 Oct;5(10):1499. PMC2612125   18456203  First Prev   1 2 of  2  Next Last

© 2008 University of Alabama at Birmingham. All rights reserved. DisclaimerAbout this SiteGraphic Design Created by UAB Web Communications.
Calendar Designed by Medical Education Information Services. To report problems with the site, email us at meis@uab.edu. Last Revision: February 15, 2012.
The UAB School of Medicine Mailing Address: 1530 3rd Avenue South, FOT 1203, Birmingham AL 35294-3412