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Faculty Detail     Name RAKESH PRAVINCHANDRA PATEL   Campus Address BMR2 532 Zip 2182 Phone 205-975-9225 E-mail rakeshp@uab.edu Other websites

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Pathology   Molecular & Cellular Pathology Professor Secondary  Anesthesiology   Anesthesiology Chair Office Associate Professor Center  Center for Aging  Center for Aging Professor Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor Center  Medicine  Comprehensive Diabetes Ctr Professor Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Professor Center  Cell, Developmntl, & Integrative Biology  Ctr for Exercise Medicine Professor Center  Medicine  Ctr Cardiovasc Bio Professor Center  Medicine  Nephrology Res & Trng Ctr Professor

Graduate Biomedical Sciences Affiliations Biochemistry and Structural Biology  Cancer Biology  Integrative Biomedical Sciences  Medical Scientist Training Program  Molecular and Cellular Pathology Program  Pathobiology and Molecular Medicine

Biographical Sketch  Dr Patel graduated from the University of Essex, UK, where he also obtained his Ph.D in 1996. He then joined the Department of Pathology, University of Alabama at Birmingham (UAB) as a post-doctoral fellow, where he is currently Professor and director of the HHHMI Med to Grad program and Department of Pathology Graduate program. Dr Patel’s research centers on understanding the mechanisms that regulate acute and chronic inflammation with a goal of using these insights to develop and test therapeutics targeted to prevent or limit inflammatory injury. Current areas of research include i) investigating how heme proteins interface with reactive oxygen and nitrogen species (including nitric oxide and nitrite) to modulate transfusion toxicity, acute lung injury and ischemia reperfusion injury and ii) understanding how post-translational regulation of protein by N-glycans regulate endothelial cell reactivity and monocyte adhesion in the context of atherosclerosis.

Society Memberships Organization Name Position Held Org Link American Physiological Society      American Society of Biochemistry and Molecular Biology      Biochemical Society      International Society for Free Radical Research      Society for Free Radical Biology and Medicine      Society for Glycobiology

Research/Clinical Interest Title Modulation of Inflammation by Reactive Species and N-glycans Description Inflammation is recognized as a key component in the development of both acute and chronic diseases affecting all organ systems. Reactive species (also referred to as free radicals or reactive oxygen, nitrogen or chlorine species) have been identified as important mediators in inflammation with roles in both initiating and preventing disease. We are interested in understanding what regulates the reactivity and function of reactive species and pursue this aim in the following contexts 1) interactions of nitric oxide and nitrite with red blood cells during normal physiological conditions, during red cell storage and inflammation associated with Sepsis, ischemia-reperfusion and transfusion –related injury. Specifically, we are pursuing the idea that hemoglobin regulates blood flow and acts as a switch that controls the anti- and pro-inflammatory effects of nitric oxide 2) evaluating mechanisms by which inhaled toxicants (specifically Chlorine gas) impairs endogenous nitric oxide signaling and developing nitric oxide based therapeutic strategies to limit chlorine gas induced pulmonary toxicity, 3) anti-inflammatory effects of dietary antioxidants. Specifically, consumption of isoflavones is associated with decreased incidence of the chronic inflammatory disease, atherosclerosis. We are investigating the mechanisms of these effects and focusing on how synergistic interactions between components in the diet, and physical forces associated with blood flow modulate endothelial surface N-glycans which in turn control monocyte adhesion during inflammation, 4) Finally, we are translating insights gained from these studies into the clinic by evaluating NO-based therapeutics in inflammatory diseases and specifically organ transplantation.

Selected Publications  Publication PUBMEDID Vitturi DA, Sun CW, Harper VM, Thrash-Williams B, Cantu-Medellin N, Chacko BK, Peng N, Dai Y, Wyss JM, Townes T, Patel RP (2012) Free Rad Biol Med Antioxidant functions for the hemoglobin β93 cysteine residue in erythrocytes and in the vascular compartment in vivo. [Epub ahead of print]   23159546  El-Ferzli GT, Dreher M, Patel RP, Ambalavanan N.(2012) ABO blood group is associated with response to inhaled nitric oxide in neonates with respiratory failure. PLos One 7(9)   22984626  Samal AA, Honavar J, Brandon A, Bradley KM, Doran S, Liu Y, Dunaway C, Steele C, Postlethwait EM, Squadrito GL, Fanucchi MV, Matalon S, Patel RP.(2012) Administration of nitrite after chlorine gas exposure prevents lung injury: effect of administration modality. Free Rad Biol Med 53(7):1431-9   22917977  Scott DW, Chen J, Chacko BK, Traylor JG Jr, Orr AW, Patel RP.(2012). Role of endothelial N-glycan mannose residues in monocyte recruitment during atherogenesis. ATVB 32(8) Epub Ahead of print   22723438  Stapley R, Owusu BY, Brandon A, Cusick M, Rodriguez C, Marques MB, Kerby JD, Barnum SR, Weinberg JA, Lancaster JR Jr, Patel RP. (2012) Erythrocyte storage increases rates of NO and nitrite scavenging: implications for transfusion-related toxicity.Biochem J. 446(3);499-508   22720637  Owusu BY, Stapley R, Patel RP.(2012)Nitric oxide formation versus scavenging: the red blood cell balancing act. J. Physiol. 590(Pt20):4993-5000   22687616  Greenway FL, Predmore BL, Flanagan DR, Giordano T, Qiu Y, Brandon A, Lefer DJ, Patel RP, Kevil CG.(2012)Single-dose pharmacokinetics of different oral sodium nitrite formulations in diabetes patients.Diabetes Technol Ther. 2012 Jul;14(7):552-60   22468627  Weinberg JA, Barnum SR, Patel RP.(2012)Red blood cell age and potentiation of transfusion-related pathology in trauma patients.Transfusion. 2011 Apr;51(4):867-73.   21496048  Christopher G Kevil and Rakesh P Patel (2010) S-nitrosothiol biology and Therapeutic potential in metabolic disease. Current Opinion in Investigational Drugs. 10: 1127-34   20872315  T. Scott Isbell, Chiao-Wang Sun, Li-Chen Wu, Xinjun Teng, Dario A. Vitturi, Billy G Branch, Christopher G Kevi, Namasivayam Ambalavanan Lisa Schwiebert, Jinxiang Ren, Kevin M. Pawlik, Matthew B. Renfrow, Rakesh P. Patel*, Tim M. Townes*. (2008) Role of SNO-Hemoglobin in Normal Development and Physiology. Nature Medicine 14(7); 773 * Co-senior author   18516054  First Prev   1 2 3 of  3  Next Last

Keywords vascular, hemoglobin, red cells, Inflammation, isoflavones, Nitric oxide, nitrite, N-glycan

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