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Faculty Detail     Name TIMOTHY R NAGY   Campus Address WEBB 419 Zip 3360 Phone 205-934-4088 E-mail tnagy@uab.edu Other websites http://main.uab.edu/shrp/default.aspx?pid=79590

Faculty Appointment(s) Appointment Type Department Division Rank Center  Arthritis & Musculoskeletal Diseases Center  Arthritis & Musculoskeletal Diseases Center Center  Center for Aging  Center for Aging Center  Center for Metabolic Bone Disease  Center for Metabolic Bone Disease Center  Comprehensive Cancer Center  Comprehensive Cancer Center Center  Medicine  Comprehensive Diabetes Ctr Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Center  Cell, Developmntl, & Integrative Biology  Ctr for Exercise Medicine Center  Medicine  Ctr Cardiovasc Bio Center  General Clinical Research Center  Minority Health & Research Center

Graduate Biomedical Sciences Affiliations Hughes Med-Grad Fellowship Program  Medical Scientist Training Program

Society Memberships Organization Name Position Held Org Link American Association for Cancer Research      American Diabetes Associations      American Physiological Society      American Society for Bone Mineral Research      American Society for Nutritional Sciences      Comparative Nutrition Society      North American Association for the Study of Obesity

Research/Clinical Interest Title Atypical antipsychotic drug-induced weight gainObesity, caloric restriction and cancerSmall-animal phenotyping Description Dr. Nagy is a Professor of Nutrition Sciences, Director of the Division of Physiology and Metabolism, and Director of the PhD Program in Nutrition Sciences. He directs the Small Animal Phenotyping Laboratory that is a resource for the UAB Clinical Nutrition Research Center, the UAB Center for Metabolic Bone Disease, and the UAB Neuroscience Blueprint Center. Dr. Nagys research is focused on three areas: (1) the regulation of body weight, (2) the development and validation of methods for phenotyping small animals, and (3) the link among body fat, caloric restriction and cancer. Dr. Nagys studies on the regulation of body weight have utilized both humans and animal models. Currently his studies are focused on animal models to better understand the mechanisms regulating energy expenditure and thus body weight. These studies include antipsychotic drug-induced weight gain, the role of uncoupling proteins, and the role of dairy in weight loss and bone health. During Dr. Nagys studies on the regulation of energy expenditure using animal models, he realized the need to improve the measurement of body composition in small animals, especially in vivo methods. Thus, he worked with two medical imaging companies to adapt human peripheral dual-energy X-ray absorptiometers (DXA) for use with mice. Dr. Nagy was the first to validate and publish on the use of DXA for measurements of fat, lean, and bone in mice. He has extended his interest in imaging techniques to that of peripheral quantitative computed tomography (pQCT). His studies have demonstrated that pQCT can be used to determine relative body fat and the relative fat content of organs in mice and rats. Recently, Dr. Nagy acquired a micro-computed tomography instrument and is currently validating its use for both hard and soft tissue. These non-invasive techniques are extremely useful and important tools for bone and obesity researchers using animal models in their research. The final area of research interest is the link among body fat, caloric restriction, and cancer. Dr. Nagy has developed a mouse model in which energy intake can be held constant while body fat is modified by varying energy expenditure using ambient temperature. Thus multiple groups of mice, whose body fat are vastly different but food intake is the same, can be studied. This line of research will determine the independent effects of body fat on cancer.

Selected Publications  Publication PUBMEDID Nagy TR, ML Blaylock, and WT Garvey. 2004. Role of UCP2 and 3 in nutrition and obesity. Nutrition. 20:139-144.    Cope MB, TR Nagy, JR Fernandez, N Geary, DE Casey, and DB Allison. 2005. Antipsychotic drug-induced weight gain: development of an animal model. Int. J. Obesity, 29:607-614.    Chen A, B Brar, CS Choi, D Rousso, J Vaughan, U Kuperman, SN Kim, C Donaldson, SM Smith, C Li, TR Nagy, GI Shulman, KF Lee, and W Vale. 2006. Urocortin 2 modulates glucose utilization and insulin sensitivity in skeletal muscle. PNAS,103:16580-16585.    Huffman DM, MS Johnson, A Watts, A Elgavish, IA Eltoum, and TR Nagy. 2007. Cancer progression in the transgenic adenocarcinoma of mouse prostate mouse is related to energy balance, body mass, and body composition, but not food intake. Cancer Res., 67:417-424.    Cope MB, P Jumbo-Lucioni, RG Walton, RA Kesterson, DB Allison, and TR Nagy. 2007. No effect of dietary fat on short-term weight gain in mice treated with atypical antipsychotic drugs. Int. J. Obesity, 31:1014-1022.    Huffman DM, WE Grizzle, MM Bamman, J Kim, IA Eltoum, A Elgavish, and TR Nagy. 2007. SIRT1 is significantly elevated in mouse and human prostate cancer. Cancer Res., 67:6612-6618.

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