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Faculty Detail     Name MAAIKE EVERTS   Campus Address CHB 302 Zip 1711 Phone 205-934-2973 E-mail maaike@uab.edu Other websites

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Pediatrics   Ped - Infectious Disease Associate Professor Center  Comprehensive Cancer Center  Comprehensive Cancer Center Associate Professor Center  General Clinical Research Center  Comprehensive Neuroscience Center Associate Professor Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Associate Professor Center  Medicine  Gene Therapy Center Associate Professor

Graduate Biomedical Sciences Affiliations Cancer Biology  Pathobiology and Molecular Medicine

Biographical Sketch  Dr. Everts is an Associate Professor in the School of Medicine, Department of Pediatrics, Division of Infectious Disease. She received a M.Sc. in Pharmaceutical Sciences from the University of Groningen and a Ph.D. in Pharmacokinetics and Drug Delivery from the Groningen University Institute for Drug Exploration (GUIDE), the Netherlands, with a thesis entitled 'Selective delivery of dexamethasone to inflamed endothelium via E-selectin', under mentorship of Drs. G. Molema, D.K.F. Meijer and L.F.M.H. de Leij. She then moved on to do her postdoctoral training under supervision of Dr. David T. Curiel in the Division of Human Gene Therapy, UAB, to pursue her research interest in targeted gene delivery for the treatment of cancer. She joined the faculty of the Department of Pathology at UAB in August 2005 as an Instructor, and continued her research on targeted therapies using gene therapy and nanotechnology approaches. In June of 2009, she transitioned to the role of Research Project Director of the Alabama Drug Discovery Alliance, which is a collaboration between UAB and Southern Research Institute.

Society Memberships Organization Name Position Held Org Link             American Association for Cancer Research  Member  www.aacr.org

Research/Clinical Interest Title Drug Discovery Description Dr. Everts is Research Project Director with the Alabama Drug Discovery Alliance; in that capacity she interfaces with a wide range of scientists involved in the drug discovery and development process, with a focus on projects in oncology, infectious diseases and neurodegenerative disorders.

Selected Publications  Publication PUBMEDID Everts M, Knight WB, Harris DR, Secrist JA 3rd, Whitley RJ. The Alabama Drug Discovery Alliance: a collaborative partnership to facilitate academic drug discovery. Pharm Res. 2011 Jul;28(7):1454-9  21448756  Saini V, Martyshkin DV, Mirov SB, Perez A, Perkins G, Ellisman MH, Towner VD, Wu H, Pereboeva L, Borovjagin A, Curiel DT, Everts M. An Adenoviral Platform for Selective Self-Assembly and Targeted Delivery of Nanoparticles.Small. 2008 Feb 1;4(2):262-269.   18200644   Everts, M. Thermal Scalpel to Target Cancer. Exp Rev Med Device, 2007, Mar;4(2):131-6  17359220  Saini, V., V.P. Zharov, C.S. Brazel, D.E. Nikles, D.T. Johnson, M. Everts. Combination of Viral Biology and Nanotechnology: New Applications in Nanomedicine. Nanomedicine, 2006, 2:200-206  17292143  Everts, M., V. Saini, J.L. Leddon, R.J. Kok, M.A. Stoff-Khalili, M.A. Preuss, C.L. Millican, G. Perkins, J.M. Brown, H. Bagaria, D.E. Nikles, D.T. Johhson, V.P. Zharov, D.T. Curiel. Covalently Linked Au Nanoparticles to a Viral Vector: Potential Transport Vehicle for Combined Photothermal and Gene Cancer Therapy. Nano Letters, 2006, 6(4):587-91  16608249  Zharov, V.P., J.W. Kim, D.T. Curiel, M. Everts. Self-assembling nanoclusters in living systems: application for integrated photothermal nanodiagnostics and nanotherapy. Nanomedicine, 2005, 1(4): 326-345    Everts, M., S.A. Kim-Park, M.A. Preuss, M.J. Passineau, J.N. Glasgow, P.J. Mahasreshti, W.E. Grizzle, P.N. Reynolds, D.T. Curiel. Selective induction of tumor-associated antigens in murine pulmonary vasculature using double-targeted adenoviral vectors. Gene Ther., 2005, 12(13): 1042-1048    Everts, M., D.T. Curiel. Transductional targeting of adenoviral cancer gene therapy. Curr. Gene Ther., 2004, 4(3): 337-346    Everts, M., R.J. Kok, S.A. Ásgeirsdóttir, B.N. Melgert, T.J.M. Moolenaar, G.A. Koning, M.J.A. van Luyn, D.K.F. Meijer, G. Molema. Selective intracellular delivery of dexamethasone into activated endothelial cells using an E-selectin directed immunoconjugate. J. Immunol., 2002, 168: 883-889.

Keywords drug discovery, nanotechnology, gene therapy, oncology

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