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Faculty Detail    
Name GENE P SIEGAL
Executive Vice-Chair
Division Director of Anatomic Pathology
 
Campus Address HSB 149K Zip 6823
Phone 205-934-6608
E-mail gsiegal@uab.edu
Other websites
     

Education
Undergraduate  Adelphi University    1970  B.A. 
Medical School  University of Louisville    1974  M.D. 
Residency  Mayo Graduate School of Medicine    1976  Resident in Pathology 
Graduate  University of Minnesota     1979  Ph.D. 
Fellowship  NCI, NIH    1981  Post-Doctoral Fellowship 
Fellowship  University of Minnesota Medical School    1982  Fellow in Surgical Pathology 

Certifications
National Board of Medical Examiners  1975 
American Board of Pathology  1978 
Certificate in Hospital Management  1988 
American Board of Pathology - Recertification  2012 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Pathology   Anatomic Pathology Professor
Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Professor
Secondary  Surgery   Surgery - General Surgery Professor
Center  Biomedical Engineering  Biomatrix Eng Regen Med (BERM) Ctr Professor
Center  Center for Biophysical Sciences/Engineering  Center for Biophysical Sciences/Engineering Professor
Center  Center for Metabolic Bone Disease  Center for Metabolic Bone Disease Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  Comprehensive Ctr for Healthy Aging  Comprehensive Ctr for Healthy Aging Professor
Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Professor
Center  Medicine  Gene Therapy Center Professor
Center  General Clinical Research Center  Nephrology Research & Training Center Professor

Graduate Biomedical Sciences Affiliations
Cancer Biology 
Integrative Biomedical Sciences 
Medical Scientist Training Program 
Molecular and Cellular Pathology Program 

Biographical Sketch 
Dr. Siegal was born in New York where he attended college. He received his medical degree from the University of Louisville and his PhD from the University of Minnesota. He was a Resident and Research Fellow at the Mayo Graduate School of Medicine and completed both a post-doctoral fellowship at the National Cancer Institute, NIH and a surgical pathology fellowship at the University of Minnesota. Prior to coming to UAB in 1990, he was a tenured faculty member at the University of North Carolina at Chapel Hill. Dr. Siegal has been married for over 40 years and has 2 adult daughters and 4 grandchildren.

Society Memberships
Organization Name Position Held Org Link
Alpha Omega Alpha, the Medical Honor Society     
American Association for Cancer Research     
American Association for the Advancement of Science     
American Medical Association     
American Society for Clinical Pathology [Fellow]   Executive Committee   
American Society for Investigative Pathology   Past Executive Committee   
Arthur Purdy Stout Society of Surgical Pathologists   Past-President   
Association of Clinical Scientists [Fellow]     
Association of Directors of Anatomic and Surgical Pathology   Past Executive Committee   
College of American Pathologists [Fellow]   Chair-Publications Committee   

Research/Clinical Interest
Title
Gene therapy of solid tumors, cancer biology, tumors of bone
Description
Dr. Siegal is an extramurally funded experimental and diagnostic pathologist whose research interest for more than 3 decades has been focused in Cancer Biology. Specifically, he has been interested in studying tumor-matrix interactions during angiogenesis, tumor invasion and metastasis in breast cancer. Previous efforts by his group have been directed towards developing new reliable in vitro model systems for studying the effect of nutritional and other factors on prostate and breast cancer progression in humans. He has participated in multiple gene therapy studies utilizing a variety of distinct strategies including mutation compensation, genetic immunopotentiation, and molecular chemotherapy to treat solid human neoplasms, principally ovarian carcinoma. He was most recently funded to develop a conditionally replicating canine adenovirus model that could be used to study host-vector interactions for more effective antitumor oncolytic effect. Dr. Siegal also directs the Histomorphometry & Molecular Analysis Core of the UAB Core Center for Musculoskeletal Disorders. Dr. Siegal's clinical research interests have focused on studies of bone tumors and related conditions. He is the Editor-in-Chief of Laboratory Investigation and serves on the editorial board of an additional twenty journals.

Selected Publications 
Publication PUBMEDID
Borinstein, S.C., Beeler, N., Block, J.J., Gorlick, R., Grohar, P., Jedlicka, P., Krailo, M., Morris, C., Phillips, S., Siegal, G.P., Lawlor, E.R., Lessnick, S. and the COG Ewing Sarcoma Biology Committee: A decade in banking Ewing Sarcoma: A report from the Children's Oncology Group. Frontiers in Pediatric Oncology. 3:57, 2013.  23519678 
Cody, J.J., Rivera, A.A., Lyons, G.R., Yang, S.W., Wang, M., Ashley, J.W., Meleth, S., Feng, X., Siegal, G.P. and Douglas, J.T.: Expression of Osteoprotegerin from a Replicating Adenovirus Inhibits the Progression of Prostate Cancer Bone Metastases in a Murine Model. Laboratory Investigation. 93(3):268-278, 2013.   23358109 
Listinsky, J.J., Siegal, G.P. and Listinsky, C.M.: Glycoengineering in Cancer Therapeutics: A Review with Fucose-Depleted Trastuzumab as the Model. Anti-Drug Research. 24(3):219-227, 2013.   23059384 
Kim, K.H., Dmitriev, I.P., Saddekni, S., Kashentseva, E.A, Harris, R.D., Aurigemma, R., Bae, S., Singh, K.P., Siegal, G.P., Curiel, D.T., and Alvarez, R.D.: A Phase I Clinical Trial of Ad5/3Δ24, a Novel Serotype-Chimeric, Infectivity-Enhanced, Conditionally-Replicative Adenovirus (CRAd), in Patients with Recurrent Ovarian Cancer. Gynecologic Oncology. 130(3):518-524, 2013.   23756180 
Daft, P.G., Yuan, K., Warram, J., Klein, M., Siegal, G.P. and Zayzafoon, M.: Alpha-CaMKII Plays a Critical Role in Determining the Aggressive Behavior of Human Osteosarcoma. Molecular Cancer Research. 11(4):349-59, 2013.   23364534 
Ebb, D., et al.: Phase II Trial of Trastuzumab in Combination with Cytotoxic Chemotherapy for Treatment of Metastatic Osteosarcoma with HER2 Overexpression: A Report from The Children's Oncology Group. J Clin Oncol. 30(20):2545-2551, 2012.   22665540 
Sawant, A., et al.: Depletion of plasmacytoid dendritic cells inhibits tumor growth and prevents bone metastasis of the breast cancer cells. J Immunol. 189(9):4258-65, 2012.  23018462 
Zhang, Y., et al.: Regeneration of Pancreatic Non-ß Endocrine Cells in Adult Mice Following a Single Diabetes Inducing Dose of Streptozotocin. PLoS One 7(5):e36675, 2012.   22586489 
Bai, S. Siegal, G.P.and Li, N.: Foxp3 Expression Patterns in Microscopic Colitides. Am J Clin Pathol 137(6):931-936, 2012.   22586052 
Rezonzew, G., et al.: Nicotine Exposure and the Progression of Chronic Kidney Disease: Role of the Alpha 7-Nicotinic Acetylcholine Receptor. Am J Physiol - Renal Physiol. 303(2):F304-312, 2012.   22552933 
Kim, K.H., et al.: A Phase I Clinical Trial of Ad5.SSTR/TK.RGD, a Novel Infectivity-Enhanced Bicistronic Adenovirus, in Patients with Recurrent Gynecologic Cancer. Clin Cancer Res. 18(12):3440-3451, 2012.   22510347 
Li, R., Kelley,.D. and Siegal, G.P. Bilateral mesenchymal hamartoma of the chest wall in an infant boy: a case report. Fetal Ped Pathol. 31(6):415-422, 2012.  22506929 
Brandwein-Gensler, M. and Siegal, G.P.: Striking Pathology Gold: A Singular Experience with Daily Reverberations: Sinonasal Hemangiopericytoma (Glomangiopericytoma) and Oncogenic Osteomalacia. Head Neck Pathol. 6(1):64-74, 2012.
 
22430770 
Nunez, A.L., Siegal, G.P., Reddy, V.V.B., Wei, S.: CD138 (Syndecan-1) Expression in Bone forming Tumors. Am J Clin Pathol. 137:423-428, 2012.   22338054 
Pan, Z., et al.: A Novel t(6;13)(q15;q34) Translocation In a Giant Cell Repartative Granuloma (Solid Aneurysmal Bone Cyst). Human Pathol. 43(6):952-957, 2012.   22285042 
Siegal, H.J., Lopez-Ben, R., Sutton, J.H. and Siegal, G.P.: Intracranial Meningeal Hemangiopericytoma Metastatic to the Scapula. Orthopedics. 35(1):72[e112-115], 2012.   22229602 
Wei, S., et al.: Complex Analysis of a Recurrent Pleomorphic Hyalinizing Angiectatic Tumor of Soft Parts. Human Pathol. 43(1):121-126, 2012.   21733556  
Borak, S., Siegal, G.P., Reddy, V., Jhala, N. and Jhala, D.: Metastatic Inflammatory Myofibroblastic Tumor Identified by EUS-FNA in Mediastinal Lymph Nodes with Ancillary FISH Studies for ALK Rearrangement. Diag Cytopathol. X:In Press, 2012.   21472870 
Wei S and Siegal, G.P.: A 23-Year-Old Woman With a Right Femoral Neck Fracture [Primary Hyperparathyroidism]. J Am Med Assoc [JAMA]. 306(21):2385-2386, 2011.   22147386 
Yang, S.W., et al.: Conditionally Replicating Adenovirus Expressing TIMP2 Increases Survival in a Mouse Model of Disseminated Ovarian Cancer. PloS One. 6(10):e25131, 2011.   22022379  
Listinsky, J.J., Siegal, G.P. And Listinsky, C.M.: The Emerging Importance of Alpha-L-Fucose In Human Breast Cancer: A Review. Am J Translat Res.3(4):292-322, 2011.   21904652 
Shanmugam, C., et al.: Evaluation of Lymph Node Numbers for Adequate Staging of Stage II and III Colon Cancer. J Hematol Oncol 4(1):25, 2011.   21619690 
Bell, P.D., et al.: Interactions Between Cilia, Hypertrophic Signaling, And Cystogenesis. J Am Soc Nephrol [JASN] 22(5):839-848, 2011
 
21493775 
Bai, S., Wang, D., Klein, M.J., and Siegal, G.P.: Characterization of CXCR4 expression in chondrosarcoma of bone. Arch Pathol Lab Med. 135(6):753-758, 2011.   21419218  
Anderson, J.T., et al.: Elevated Levels of NO are localized to distal airways in asthma. Free Radl Biol Med 50(11):1679-1688, 2011.   21419218  
Kim, K.H., et al.: A new generation of serotype chimeric infectivity-enhanced conditionally replicative adenovirals: the safety profile of ad5/3-Δ24 in advance of a phase I clinical trial in ovarian cancer patients.
Human Gene Ther. 22(7):821-828, 2011.  
21171861 
Wei, S., Li, Y., Siegal, G.P. and Hameed, O.: Breast Carcinomas with Isolated Bone Metastases Have Different Hormone Receptor Expression Profiles than Those with Metastases to Other Sites or Multiple Organs Ann Diagn Pathol. 15(2):79-83, 2011.   21163679 
Yang, S.W., et al.: Conditionally Replicating Adenovirus Expressing TIMP2 for Ovarian Cancer Therapy. Clin Cancer Res. 17(3):538-549, 2011   21115652  
Hensel, J.A., et al.: LL-37 as a Therapeutic Target.for Late Stage Prostate Cancer. Prostate. 71(6)659-670, 2011.   20957672 
Kimball, K.J., et al.: A Phase I Study of a Tropism-Modified Conditionally Replicative Adenovirus for Recurrent Malignant Gynecologic Diseases. Clin Cancer Res. 16(21):5277-5287, 2010.   20978148 
Cody, J.J., et al.: Arming a Replicating Adenovirus with Osteoprotegerin Reduces the Tumor Burden in a Murine Model of Osteolytic Bone Metastases of Breast Cancer. Cancer Gene Ther. 17(12): 893–905, 2010.   20798695 
Andea, A., et al.: Merkel Cell Carcinoma: Correlation of KIT expression with survival and evaluation of KIT gene mutational status. Human Pathol. 41(10):1405-1412, 2010.
 
20594584 
Douglas, J.T., Rivera, A.A., Lyons, G.R., Lott, P.F., Wang, D., Zayzafoon, M., Siegal, G.P., Cao, X. and Theiss, S.M.: Ex Vivo Transfer of the Hoxc-8-interacting Domain of Smad1 by a Tropism-Modified Adenoviral Vector Results in Efficient Bone Formation in a Rabbit Model of Spinal Fusion. J Spinal Disord Tech. 23(1):63-73, 2010.   20084034 
Baker, A.C., et al.: Aggressive Osteoblastoma: A case report involving a unique chromosomal aberration. Intl J Surg Pathol. 18(6):219-224, 2010.   18611933 

Keywords
Bone Tumors, Cancer Gene Therapy, Invasion and Metastasis