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Faculty Detail     Name GENE P SIEGAL   Campus Address HSB 149K Zip 6823 Phone 205-934-6608 E-mail gsiegal@uab.edu Other websites

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Pathology   Anatomic Pathology Professor Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Professor Center  Center for Aging  Center for Aging Professor Center  Center for Metabolic Bone Disease  Center for Metabolic Bone Disease Professor Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Professor Center  Medicine  Gene Therapy Center Professor Center  Medicine  Nephrology Res & Trng Ctr Professor

Graduate Biomedical Sciences Affiliations Cancer Biology  Integrative Biomedical Sciences  Medical Scientist Training Program  Molecular and Cellular Pathology Program

Biographical Sketch  Dr. Siegal was born in New York where he attended college. He received his medical degree from the University of Louisville and his PhD from the University of Minnesota. He was a Resident and Research Fellow at the Mayo Graduate School of Medicine and completed both a post-doctoral fellowship at the National Cancer Institute, NIH and a surgical pathology fellowship at the University of Minnesota. Prior to coming to UAB in 1990, he was a tenured faculty member at the University of North Carolina at Chapel Hill. Dr. Siegal has been married for 40 years and has 2 adult daughters and 3 grandchildren.

Society Memberships Organization Name Position Held Org Link Alpha Omega Alpha, the Medical Honor Society      American Association for Cancer Research      American Association for the Advancement of Science      American Medical Association      American Society for Clinical Pathology [Fellow]   Executive Committee    American Society for Investigative Pathology   Past Executive Committee    Arthur Purdy Stout Society of Surgical Pathologists   Past-President    Association of Clinical Scientists [Fellow]      Association of Directors of Anatomic and Surgical Pathology   Past Executive Committee    College of American Pathologists [Fellow]   Chair-Publications Committee    First Prev   1 2 of  2  Next Last

Research/Clinical Interest Title Gene therapy of solid tumors, cancer biology, tumors of bone Description Dr. Siegal is an extramurally funded experimental and diagnostic pathologist whose research interest for more than 3 decades has been focused in Cancer Biology. Specifically, he has been interested in studying tumor-matrix interactions during angiogenesis, tumor invasion and metastasis in breast cancer. Previous efforts by his group have been directed towards developing new reliable in vitro model systems for studying the effect of nutritional and other factors on prostate and breast cancer progression in humans. He has participated in multiple gene therapy studies utilizing a variety of distinct strategies including mutation compensation, genetic immunopotentiation, and molecular chemotherapy to treat solid human neoplasms, principally ovarian carcinoma. He was most recently funded to develop a conditionally replicating canine adenovirus model that could be used to study host-vector interactions for more effective antitumor oncolytic effect. Dr. Siegal also directs the Histomorphometry & Molecular Analysis Core of the UAB Core Center for Musculoskeletal Disorders. Dr. Siegal's clinical research interests have focused on studies of bone tumors and related conditions. He is the Editor-in-Chief of Laboratory Investigation and serves on the editorial board of an additional seventeen journals.

Selected Publications  Publication PUBMEDID Sawant, A., et al.: Depletion of plasmacytoid dendritic cells inhibits tumor growth and prevents bone metastasis of the breast cancer cells. J Immunol. 189(9):4258-65, 2012., doi: 10.4049/jimmunol.1101855.  23018462  Ebb, D., et al.: Phase II Trial of Trastuzumab in Combination with Cytotoxic Chemotherapy for Treatment of Metastatic Osteosarcoma with HER2 Overexpression: A Report from The Children's Oncology Group. J Clin Oncol. 30(20):2545-2551, 2012.   22665540  Zhang, Y., et al.: Regeneration of Pancreatic Non-ß Endocrine Cells in Adult Mice Following a Single Diabetes Inducing Dose of Streptozotocin. PLoS One 7(5):e36675, 2012.   22586489  Bai, S. Siegal, G.P.and Li, N.: Foxp3 Expression Patterns in Microscopic Colitides. Am J Clin Pathol 137(6):931-936, 2012.   22586052  Rezonzew, G., et al.: Nicotine Exposure and the Progression of Chronic Kidney Disease: Role of the Alpha 7-Nicotinic Acetylcholine Receptor. Am J Physiol - Renal Physiol. 303(2):F304-312, 2012.   22552933  Kim, K.H., et al.: A Phase I Clinical Trial of Ad5.SSTR/TK.RGD, a Novel Infectivity-Enhanced Bicistronic Adenovirus, in Patients with Recurrent Gynecologic Cancer. Clin Cancer Res. 18(12):3440-3451, 2012.   22510347  Li, R., Kelley,.D. and Siegal, G.P. Bilateral mesenchymal hamartoma of the chest wall in an infant boy: a case report. Fetal Ped Pathol. 31(6):415-422, 2012., doi:10.3109/15513815.2012.659412.   22506929  Brandwein-Gensler, M. and Siegal, G.P.: Striking Pathology Gold: A Singular Experience with Daily Reverberations: Sinonasal Hemangiopericytoma (Glomangiopericytoma) and Oncogenic Osteomalacia. Head Neck Pathol. 6(1):64-74, 2012.   22430770  Nunez, A.L., Siegal, G.P., Reddy, V.V.B., Wei, S.: CD138 (Syndecan-1) Expression in Bone forming Tumors. Am J Clin Pathol. 137:423-428, 2012.   22338054  Pan, Z., et al.: A Novel t(6;13)(q15;q34) Translocation In a Giant Cell Repartative Granuloma (Solid Aneurysmal Bone Cyst). Human Pathol. 43(6):952-957, 2012.   22285042  First Prev   1 2 3 4 of  4  Next Last

Keywords Bone Tumors, Cancer Gene Therapy, Invasion and Metastasis

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