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Faculty Detail     Name ELIZABETH S SZTUL   Campus Address MCLM 668 Zip 0005 Phone 205-934-1465 E-mail esztul@uab.edu Other websites

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Professor Secondary  Neurobiology  Neurobiology Professor Center  Arthritis & Musculoskeletal Diseases Center  Arthritis & Musculoskeletal Diseases Center Professor Center  Civitan International Research Center  Civitan International Research Center Professor Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor Center  Cystic Fibrosis Research Center  Cystic Fibrosis Research Center Professor Center  Medicine  Nephrology Res & Trng Ctr Professor

Graduate Biomedical Sciences Affiliations Biochemistry and Structural Biology  Cell, Molecular, & Developmental Biology  Cellular and Molecular Biology Program  Medical Scientist Training Program  Neuroscience  Neuroscience Graduate Program

Biographical Sketch  Elizabeth S. Sztul obtained a M.Sc. (1979) in Plant Physiology from University of Maryland, studying chloroplast biogenesis. She continued her graduate studies in Cell Biology at Yale University School of Medicine, working on membrane trafficking pathways in the laboratory of Nobel Prize winner, Dr. George Palade, and was awarded a Ph.D in 1984. She continued training as a Postdoctoral Fellow of the American Cancer Society (1985-1989) in Human Genetics at Yale University School of Medicine, working on mitochondrial biogenesis in the laboratory of Dr. Leon Rosenberg. During her postdoctoral work at Yale, she was also a Visiting Scientist at the European Molecular Biology Laboratory in Heidelberg, Germany, in the laboratory of Dr. Kathryn Howell. She was appointed Assistant Professor of Molecular Biology at Princeton University (1989-1995), where she received the National Science Foundation Presidential Young Investigator Award. Dr. Sztul joined the faculty in the Department of Cell Biology at UAB as an Associate Professor in Fall of 1995. She is a member of the UAB Comprehensive Cancer Center and of the Fleming Cystic Fibrosis Center. She spent a sabbatical year (2000-01) at the Wellcome Center for Human Genetics in Oxford, United Kingdom, in the laboratory of Dr. Yvonne Jones. At the national level she has served or serves on Scientific Advisory Panels for the National Institute of Health, American Cancer Society, National Science Foundation and the American Heart Association.

Society Memberships Organization Name Position Held Org Link ASCB

Research/Clinical Interest Title Membrane Traffic; Protein Degradation Description My research interests focus on the molecular mechanisms that regulate the delivery of proteins to their cellular sites of action. Many human diseases are caused by either the failed delivery of a specific protein to its appropriate cellular site, or by the premature degradation of a critical cellular component. For example, cystic fibrosis is caused by the inability of the CFTR protein to be delivered to the surface of cells, while certain cancers are linked to rapid degradation of the Ptc receptor. The first area of study is to understand how intracellular membrane traffic is controlled. More specifically, how do cells mediate the transport of crucial proteins to the correct site within the cell? In eukaryotic cells, proteins are sequentially transported from the site of synthesis in the endoplasmic reticulum (ER), through the Intermediate Compartment (IC) and the Golgi complex to the cell surface or to the endosomal/lysosomal system. We are developing a “virtual” time and space map of all the molecular events that occur during protein transport. We have cloned several key proteins that are required in protein transport, and are using biochemical, immunological, morphological, genetic, and molecular technologies to delineate their exact function. A detailed understanding of protein traffic at the molecular level is an essential step toward developing disease-specific therapies that correct the deficient step in protein transport that characterizes each disease. A related area of research in my laboratory is to understand the control of protein degradation. Newly synthesized proteins must fold correctly in the ER. If folding is inefficient or impossible, the protein is recognized by the ER quality control system, and is eliminated through proteasomal degradation. We have developed an in vivo system, using the genetically tractable yeast, Saccharomyces cerevisiae, to analyze how misfolded proteins are selected out of the ER and sorted for degradation. We have identified a multi-component sorting machinery in yeast that functions to sequester misfolded proteins into subdomains of the ER as a prelude for degradation. Our current focus is to identify a functionally and molecularly similar sorting system in mammalian cells. The ultimate goal of this project is to develop technology that will selectively slow down degradative sorting of clinically relevant proteins.

Selected Publications  Publication PUBMEDID Brandon E, Szul T, Alvarez C, Grabski R, Benjamin R, Kawai R, Sztul E. On and Off Membrane Dynamics of the Endoplasmic Reticulum-Golgi Tethering Factor p115 In Vivo. Mol Biol Cell. 2006 Jul;17(7):2996-3008. Epub 2006 Apr 19.   16624868  Sztul E, Lupashin V. Role of tethering factors in secretory membrane traffic. Am J Physiol Cell Physiol. 2006 Jan;290(1):C11-26. Review.   16338975   Fu L, Gao YS, Tousson A, Shah A, Chen TL, Vertel BM, Sztul E. Nuclear aggresomes form by fusion of PML-associated aggregates. Mol Biol Cell. 2005 Oct;16(10):4905-17. Epub 2005 Jul 29.   16055507  Fu L, Gao YS, Sztul E. Transcriptional repression and cell death induced by nuclear aggregates of non-polyglutamine protein. Neurobiol Dis. 2005 Dec;20(3):656-65. Epub 2005 Jun 16.   15964198  Szul T, Garcia-Mata R, Brandon E, Shestopal S, Alvarez C, Sztul E. Dissection of membrane dynamics of the ARF-guanine nucleotide exchange factor GBF1. Traffic. 2005 May;6(5):374-85.   15813748  Hosaka T, Brooks CC, Presman E, Kim SK, Zhang Z, Breen M, Gross DN, Sztul E, Pilch PF. p115 Interacts with the GLUT4 vesicle protein, IRAP, and plays a critical role in insulin-stimulated GLUT4 translocation. Mol Biol Cell. 2005 Jun;16(6):2882-90. Epub 2005 Mar 30.   15800058   Brandon E, Sztul E. h-ERES-y in ER-Golgi transport. Dev Cell. 2004 Jul;7(1):6-8. Review.   15239949  Brandon E, Gao Y, Garcia-Mata R, Alvarez C, Sztul E. Membrane targeting of p115 phosphorylation mutants and their effects on Golgi integrity and secretory traffic. Eur J Cell Biol. 2003 Aug;82(8):411-20.   14533739  Grabski R, Szul T, Sasaki T, Timpl R, Mayne R, Hicks B, Sztul E. Mutations in COCH that result in non-syndromic autosomal dominant deafness (DFNA9) affect matrix deposition of cochlin. Hum Genet. 2003 Oct;113(5):406-16. Epub 2003 Aug 20.   12928864  Garcia-Mata R, Szul T, Alvarez C, Sztul E. ADP-ribosylation factor/COPI-dependent events at the endoplasmic reticulum-Golgi interface are regulated by the guanine nucleotide exchange factor GBF1. Mol Biol Cell. 2003 Jun;14(6):2250-61. Epub 2003 Apr 4.   12808027  First Prev   1 2 3 of  3  Next Last

Keywords Cystic fibrosis, membrane traffic, degradation, quality control

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