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Faculty Detail    
Name DANIEL C BULLARD
Professor
Department of Genetics
 
Campus Address KAUL 602 Zip 0024
Phone 205-934-7768
E-mail dcbullard@uab.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Genetics   Genetics Research Div Professor
Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Professor
Center  Arthritis & Musculoskeletal Diseases Center  Arthritis & Musculoskeletal Diseases Center Professor
Center  Pathology   Cell Adhesion & Matrix Research Center Professor
Center  Center for Metabolic Bone Disease  Center for Metabolic Bone Disease Associate Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  Medicine  Comprehensive Diabetes Ctr Professor
Center  Medicine  Nephrology Res & Trng Ctr Professor

Graduate Biomedical Sciences Affiliations
Genetics and Genomic Sciences 
Immunology 
Integrative Biomedical Sciences 
Medical Scientist Training Program 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Daniel Bullard, Professor of Genetics, received his Ph.D. in 1992 from Case Western Reserve University in the field of genetics. During his postdoctoral studies in the Department of Human and Molecular Genetics at Baylor College of Medicine in Houston, he initiated research investigating the roles of leukocyte/endothelial cell adhesion molecules in inflammatory diseases such as lupus, psoriasis, and rheumatoid arthritis. He has continued this work in his laboratory at UAB.

Society Memberships
Organization Name Position Held Org Link
American Association of Immunologists     
American Society for Investigative Pathology     
Mammalian Genome Society     

Research/Clinical Interest
Title
Regulation of Immune and Inflammatory Responses
Description
My research has focused for the last 20 years on defining the cellular and genetic mechanisms by which adhesion molecules, such as the B2 integrins, ICAM-1, and the selectins regulate immune and inflammatory processes, especially during the development of chronic inflammatory disorders. Specific diseases of interest include systemic lupus erythematosus, rheumatoid arthritis, vasculitic disorders, multiple sclerosis, and psoriasis. I have extensive experience with the generation and characterization of both transgenic and gene targeted or knockout mutant mice, and through these efforts have developed an extensive set of adhesion molecule deficient mice. I have also analyzed many of these mutant lines in disease models including SLE-susceptible MRL/MpJ-Faslpr mice, collagen-induced arthritis (CIA), and experimental autoimmune encephalomyelitis (EAE). This work has identified new functions and unexpected roles for adhesion molecules in regulating the initiation and progression of autoimmunity and tissue inflammation. In addition, my lab has recently initiated a major functional genomics initiative designed to determine whether genetic variants in the ITGAM (CD11b) gene, which have been shown in multiple GWAS studies to be strongly associated with the development of lupus, potentially alter the expression, ligand binding, and function of Mac-1. The long-term goal of these studies is to determine how these ITGAM variants contribute to the pathogenesis of SLE.

Selected Publications 
Publication PUBMEDID
Ramos, T.N., Bullard, D.C., Darley M.M., McDonald K., Crawford D.F., and Barnum S.R. (2013). Experimental cerebral malaria develops independently of endothelial expression of intercellular adhesion molecule-1 (Icam-1). Journal of Biological Chemistry, 2013 288:10962-6.  23493396 
Cox, M.A., Barnum, S.R., Bullard, D.C., and Zajac, A.J. (2013). ICAM-1-Dependent Tuning of Memory CD8 T-Cell Responses Following Acute Infection, Proceedings of the National Academy of Sciences USA, 110:1416-1421.  23297203  
Schoeb, T.R., Jarmi, T., Hicks, M.J., Henke, S., Zarjou, A., Suzuki, H., Kramer, P., Novak, J., Agarwal, A., and Bullard, D.C. (2012). eNOS Inhibits the Development of Autoimmune-Mediated Vasculitis in Mice, Arthritis and Rheumatism, 64:4114-4124.  22933338 
Ramos, T.N., Bullard D.C., and Barnum, S.R. (2012). Deletion of the Complement Phagocytic Receptors CR3 and CR4 Does not Alter Susceptibility to Experimental Cerebral Malaria, Parasite Immunology, 34:547-550.  22882618  
Wu, X., Yu T., Bullard D.C., and Kucik, D.F. (2012). SDF-1α (CXCL12) Regulation of Lateral Mobility Contributes to Activation of LFA-1 Adhesion. American Journal of Physiology Cell Physiology, 303:C666-C672.  22875786  
Schoeb, T.R. and Bullard, D.C. (2012). Microbial and Histopathologic Considerations in Use of Mouse Models of Inflammatory Bowel Diseases. Inflammatory Bowel Diseases, 18:1558-1565.  22294506 
Liu, Z., Swindall, A.F., Kesterson, R.A., Schoeb, T.R., Bullard, D.C., and Bellis, S.L. (2011) ST6Gal-I regulates macrophage apoptosis via {alpha}2-6 sialylation of the TNFR1 death receptor, Journal of Biological Chemistry, 286:39654-39662.  21930713 
Hu, X., Barnum, S.R., Wohler, J.E., Schoeb, T.R., and Bullard, D.C. (2010). Differential ICAM-1 isoform expression regulates the development and progression of experimental autoimmune encephalomyelitis, Molecular Immunology, 47:1692-1700.  20371120 
Chang B.Y, Zhao F, He X, Ren H, Braselmann S, Taylor V, Wicks J, Payan D.G, Grossbard E.B, Pine P.R, and Bullard D.C. (2009). JAK3 inhibition significantly attenuates psoriasiform skin inflammation in CD18 mutant PL/J mice. The Journal of Immunology, 183:2183-2192.  19596999  
Wohler J.E., Bullard, D.C., Schoeb, T.R., and Barnum S.R. (2009). LFA-1 is critical for regulatory T cell homeostasis and function, Molecular Immunology, 46:2424-2428.  19428111  
Dugger, K.J., Zinn, K.r., Weaver, C.T., Bullard, D.C., and Barnum, S.R. (2009). Effector and suppressor roles for LFA-1 during the development of experimental autoimmune encephalomyelitis, Journal of Neuroimmunology, 206:22-27.  19010554 
Oliva, C.R., Swiecki, M.K., Griguer, C.E., Lisanby, M.W., Bullard, D.C., Turnbough, C.L., and Kearney, J.F. (2008). The Integrin Mac-1 (CR3) Mediates Internalization and Directs Bacillus anthracis Spores into Professional Phagocytes, Proceedings of the National Academy of Sciences USA, 105:1261-1266.  18216258  
Bullard, D.C., Hu, X., Adams, J.E., Schoeb, T.R., Barnum, S.R. (2007). p150,95 (CD11c/CD18) Expression is Required for the Development of Experimental Autoimmune Encephalomyelitis, The American Journal of Pathology, 170:2001-8.  17525267 
Bullard, D.C., Hu, X., Schoeb, T.R., Collins, R.G., Beaudet, A.L., and Barnum, S.R. (2007). ICAM-1 Expression is Required on T Cells for the Development of Experimental Autoimmune Encephalomyelitis, The Journal of Immunology, 178:851-857.  17202346  
He, S., Schoeb, T.R., Panoskaltsis-Mortari, A., Zinn, K.R., Kesterson, R.A., Zhang, J., Samuel, S., Hicks, M.J., Hickey, M.J., and Bullard, D.C. (2006). Deficiency of P-selectin or P-selectin Glycoprotein Ligand-1 Leads to Accelerated Development of Glomerulonephritis and Increased Expression of CC Chemokine Ligand 2 in Lupus-Prone Mice, The Journal of Immunology, 177:8748-56.  17142777 
Bullard, D.C., Hu, X., Schoeb, T.R., Axtell, R.C., Raman, C., Barnum, S.R. (2005). Critical requirement of CD11b (Mac-1) on T-cells and Accessory Cells for Development of Experimental Autoimmune Encephalomyelitis, Journal of Immunology, 175:6327-33.  16272284 
Ruth, J.H., Amin, M.A., Woods, J.M., He, X., Samuel, S.L., Yi, N., Haas, C.S., Koch, A.E., and Bullard, D.C. (2005). Accelerated Development of Arthritis in Mice Lacking Endothelial Selectins, Arthritis Research & Therapy, 7:R959-R970.  16207337 
Kevil, C.G., Hicks, M.J., He, X., Zhang, X., Ballantyne, C.M., Raman, C., Schoeb, T.R., and Bullard, D.C. Loss of LFA-1, but not Mac-1, Protects MRL/MpJ-Faslpr Mice from Autoimmune Disease, The American Journal of Pathology, 165:609-616.   15277234 
Kevil, C.G., Orr, A.W., Langston, W., Mickett, K., Murphy-Ullrich, J., Patel, R.P., Kucik, D.F., and Bullard, D.C. (2004) Intercellular Adhesion Molecule-1 (ICAM-1) Regulates Endothelial Cell Motility Through an NO Dependent Pathway, Journal of Biological Chemistry 279:19230-8.  14985356 
Barlow, S.C. Xu H., Lindsey J.R., Schoeb, T.R. and Bullard, D.C. (2004) Development of dermatitis in CD18-deficient PL/J mice is not dependent on bacterial flora, and requires both CD4+ and CD8+ T lymphocytes, International Immunology, 16:345-351.  14734620 
Barlow, S.C., Collins, R.C., Lindsey, J.R., Schoeb, T.R., and Bullard, D.C. (2003) Psoriasiform dermatitis susceptibility in Itgb2(tm1Bay) PL/J mice requires low-level CD18 expression and at least two additional loci for progression to severe disease, American Journal of Pathology, 163:197-202.   12819024 

Keywords
adhesion molecules, lupus, vasculitis, psoriasis