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Faculty Detail     Name DANIEL C BULLARD Professor Department of Genetics   Campus Address KAUL 602 Zip 0024 Phone 205-934-7768 E-mail dcbullard@uab.edu Other websites

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Genetics   Genetics Research Div Professor Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Professor Center  Arthritis & Musculoskeletal Diseases Center  Arthritis & Musculoskeletal Diseases Center Professor Center  Pathology   Cell Adhesion & Matrix Research Center Professor Center  Center for Metabolic Bone Disease  Center for Metabolic Bone Disease Associate Professor Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor Center  Medicine  Comprehensive Diabetes Ctr Professor Center  Medicine  Nephrology Res & Trng Ctr Professor

Graduate Biomedical Sciences Affiliations Genetics and Genomic Sciences  Immunology  Integrative Biomedical Sciences  Medical Scientist Training Program  Pathobiology and Molecular Medicine

Biographical Sketch  Daniel Bullard, Professor of Genetics, received his Ph.D. in 1992 from Case Western Reserve University in the field of genetics. During his postdoctoral studies in the Department of Human and Molecular Genetics at Baylor College of Medicine in Houston, he initiated research investigating the roles of leukocyte/endothelial cell adhesion molecules in inflammatory diseases such as lupus, psoriasis, and rheumatoid arthritis. He has continued this work in his laboratory at UAB.

Society Memberships Organization Name Position Held Org Link American Association of Immunologists      American Society for Investigative Pathology      Mammalian Genome Society

Research/Clinical Interest Title Regulation of Immune and Inflammatory Responses Description My research has focused for the last 20 years on defining the cellular and genetic mechanisms by which adhesion molecules, such as the B2 integrins, ICAM-1, and the selectins regulate immune and inflammatory processes, especially during the development of chronic inflammatory disorders. Specific diseases of interest include systemic lupus erythematosus, rheumatoid arthritis, vasculitic disorders, multiple sclerosis, and psoriasis. I have extensive experience with the generation and characterization of both transgenic and gene targeted or knockout mutant mice, and through these efforts have developed an extensive set of adhesion molecule deficient mice. I have also analyzed many of these mutant lines in disease models including SLE-susceptible MRL/MpJ-Faslpr mice, collagen-induced arthritis (CIA), and experimental autoimmune encephalomyelitis (EAE). This work has identified new functions and unexpected roles for adhesion molecules in regulating the initiation and progression of autoimmunity and tissue inflammation. In addition, my lab has recently initiated a major functional genomics initiative designed to determine whether genetic variants in the ITGAM (CD11b) gene, which have been shown in multiple GWAS studies to be strongly associated with the development of lupus, potentially alter the expression, ligand binding, and function of Mac-1. The long-term goal of these studies is to determine how these ITGAM variants contribute to the pathogenesis of SLE.

Selected Publications  Publication PUBMEDID Hu, X., Barnum, S.R., Wohler, J.E., Schoeb, T.R., and Bullard, D.C. (2010). Differential ICAM-1 isoform expression regulates the development and progression of experimental autoimmune encephalomyelitis, Molecular Immunology, 47:1692-1700.  20371120  Chang B.Y, Zhao F, He X, Ren H, Braselmann S, Taylor V, Wicks J, Payan D.G, Grossbard E.B, Pine P.R, and Bullard D.C. (2009). JAK3 inhibition significantly attenuates psoriasiform skin inflammation in CD18 mutant PL/J mice. The Journal of Immunology, 183:2183-2192.  19596999   Wohler J.E., Bullard, D.C., Schoeb, T.R., and Barnum S.R. (2009). LFA-1 is critical for regulatory T cell homeostasis and function, Molecular Immunology, 46:2424-2428.  19428111   Dugger, K.J., Zinn, K.r., Weaver, C.T., Bullard, D.C., and Barnum, S.R. (2009). Effector and suppressor roles for LFA-1 during the development of experimental autoimmune encephalomyelitis, Journal of Neuroimmunology, 206:22-27.  19010554  Oliva, C.R., Swiecki, M.K., Griguer, C.E., Lisanby, M.W., Bullard, D.C., Turnbough, C.L., and Kearney, J.F. (2008). The Integrin Mac-1 (CR3) Mediates Internalization and Directs Bacillus anthracis Spores into Professional Phagocytes, Proceedings of the National Academy of Sciences USA, 105:1261-1266.  18216258   Bullard, D.C., Hu, X., Adams, J.E., Schoeb, T.R., Barnum, S.R. (2007). p150,95 (CD11c/CD18) Expression is Required for the Development of Experimental Autoimmune Encephalomyelitis, The American Journal of Pathology, 170:2001-8.  17525267  Bullard, D.C., Hu, X., Schoeb, T.R., Collins, R.G., Beaudet, A.L., and Barnum, S.R. (2007). ICAM-1 Expression is Required on T Cells for the Development of Experimental Autoimmune Encephalomyelitis, The Journal of Immunology, 178:851-857.  17202346   He, S., Schoeb, T.R., Panoskaltsis-Mortari, A., Zinn, K.R., Kesterson, R.A., Zhang, J., Samuel, S., Hicks, M.J., Hickey, M.J., and Bullard, D.C. (2006). Deficiency of P-selectin or P-selectin Glycoprotein Ligand-1 Leads to Accelerated Development of Glomerulonephritis and Increased Expression of CC Chemokine Ligand 2 in Lupus-Prone Mice, The Journal of Immunology, 177:8748-56.  17142777  Bullard, D.C., Hu, X., Schoeb, T.R., Axtell, R.C., Raman, C., Barnum, S.R. (2005). Critical requirement of CD11b (Mac-1) on T-cells and Accessory Cells for Development of Experimental Autoimmune Encephalomyelitis, Journal of Immunology, 175:6327-33.  16272284  Ruth, J.H., Amin, M.A., Woods, J.M., He, X., Samuel, S.L., Yi, N., Haas, C.S., Koch, A.E., and Bullard, D.C. (2005). Accelerated Development of Arthritis in Mice Lacking Endothelial Selectins, Arthritis Research & Therapy, 7:R959-R970.  16207337  First Prev   1 2 of  2  Next Last

Keywords adhesion molecules, lupus, vasculitis, psoriasis

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