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Faculty Detail     Name DANIEL F BALKOVETZ Training Program Director for Nephrology   Campus Address LHRB 668 Zip 0007 Phone 205-934-3589 E-mail balkovet@uab.edu Other websites       ICM Preceptor

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Medicine  Med - Nephrology Professor Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Professor Center  Medicine  Nephrology Res & Trng Ctr Professor

Graduate Biomedical Sciences Affiliations Cancer Biology  Cell, Molecular, & Developmental Biology  Cellular and Molecular Biology Program  Hughes Med-Grad Fellowship Program  Medical Scientist Training Program  Pathobiology and Molecular Medicine

Biographical Sketch  Daniel Balkovetz (b. 1960), Professor, completed his M.D. and Ph.D. (Mentors Frederick Leibach and Vadivel Ganapathy) programs at the Medical College of Georgia. After his residency and postdoctoral training (Mentor David Warnock) at the University of Alabama at Birmingham, he completed Nephrology and Epithelial Cell Biology (Mentor Keith Mostov) fellowship training at the University of California, San Francisco. He joined the Nephrology and Cell Biology faculty at UAB in 1996. His outside interests include his family.

Society Memberships Organization Name Position Held Org Link American Society of Nephrology    www.asn-online.org/  Southern Society for Clinical Research      The American Physiological Society    www.the-aps.org  The American Society for Cell Biology    www.ascb.org

Research/Clinical Interest Title Epithelial Cell Biology; Epithelial Cell Signal Regulation; Regulation of paracellular transport across epithelial cell tight junctions Description We are interested in basic issues of epithelial cell biology. We are studying the control of paracellular transport across renal epithelia by a newly discovered family of tight junction associated proteins called claudins. Our lab is also examining the mechanisms controlling contact inhibition of mitosis in epithelial cells and focusing on the regulation of the ERK signaling pathway. These areas are important in the understanding of basic renal physiology as well as during important clinical situations such as organ regeneration following injury and transformation of epithelium to carcinoma. Our lab is also studying interactions of bacterial pathogens with epithelium and epithelial factors, which influence the susceptibility of the epithelium to these pathogens.

Selected Publications  Publication PUBMEDID Panwar B, Johnson VA, Patel M, Balkovetz DF.: Risk of Vancomycin-Induced Nephrotoxicity in the Population with Chronic Kidney Disease. Am J Med Sci. 2012.   23103440  Basireddy M, Lindsay JT, Agarwal A, Balkovetz DF Epithelial cell polarity and hypoxia influence heme oxygenase-1 expression by heme in renal epithelial cells. Am J Physiol Renal Physiol. 2006 Oct;291(4):F790-5. Epub 2006 Apr 18.  16622174  Balkovetz DF Claudins at the gate: determinants of renal epithelial tight junction paracellular permeability. Am J Physiol Renal Physiol. 2006 Mar;290(3):F572-9.  16461756  Zhang P, Yang QB, Balkovetz DF, Lewis JP, Clements JD, Michalek SM, Katz J Effectiveness of the B subunit of cholera toxin in potentiating immune responses to the recombinant hemagglutinin/adhesin domain of the gingipain Kgp from Porphyromonas gingivalis. Vaccine. 2005 Sep 15;23(39):4734-44   15955601  Hellman NE, Greco AJ, Rogers KK, Kanchagar C, Balkovetz DF, Lipschutz JH Activated extracellular signal-regulated kinases are necessary and sufficient to initiate tubulogenesis in renal tubular MDCK strain I cell cysts. Am J Physiol Renal Physiol. 2005 Oct;289(4):F777-85.  15900019  Lipschutz JH, Li S, Arisco A, Balkovetz DF. Extracellular-signal-regulated kinases 1/2 control claudin-2 expression in Madin-Darby canine kidney strain I and II cells. J Biol Chem. 2004 Nov 29  15569684  Burrus JK, Matheson WD, Hong JS, Sorscher EJ, Balkovetz DF. Hepatocyte growth factor stimulates adenoviral-mediated gene transfer across the apical membrane of epithelial cells. J Gene Med. 2004 Jun;6(6):624-30.  15170733  Li S, Gerrard ER Jr, Balkovetz DF. Evidence for ERK1/2 phosphorylation controlling contact inhibition of proliferation in Madin-Darby canine kidney epithelial cells. Am J Physiol Cell Physiol. 2004 Aug;287(2):C432-9.   15070810  Wade BK, Burrus JK, Balkovetz DF. Hepatocyte growth factor inhibits intrinsic antibacterial activity of Madin-Darby canine kidney cells. Microbes Infect. 2004 Jan;6(1):51-7.  14738893  Balkovetz DF, Gerrard ER Jr, Li S, Johnson D, Lee J, Tobias JW, Rogers KK, Snyder RW, Lipschutz JH. Related Articles, Links Gene expression alterations during HGF-induced dedifferentiation of a renal tubular epithelial cell line (MDCK) using a novel canine DNA microarray. Am J Physiol Renal Physiol. 2004 Apr;286(4):F702-10. Epub 2003 Dec 09.   14665430  First Prev   1 2 of  2  Next Last

Keywords epithelial cells, claudins, tight junctions, E-cadherin, hepatocyte growth factor, ERK, MDCK

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