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Faculty Detail     Name LIZHONG WANG   Campus Address KAUL 740 Zip 0024 Phone 205-934-5948 E-mail lwang12@uab.edu Other websites

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Genetics   Genetics Research Div Assistant Professor Center  Comprehensive Cancer Center  Comprehensive Cancer Center Assistant Professor

Biographical Sketch  M.D., China Medical University (1988) Ph.D., Akita University, Japan (2004) Postdoctoral Training, Ohio Satet University (2006)

Society Memberships Organization Name Position Held Org Link American Association for Cancer Research      American Association for the Advancement of Science

Research/Clinical Interest Title Cancer Genetics Description Our research interests focus on the cancer genetics and molecular epidemiology involved in prostate cancer and breast cancer. Our recent research showed that the somatic genetic alterations in a novel tumor suppressor gene FOXP3 with a single-hit mechanism have an important impact on developing both breast cancer and prostate cancer. We are going to investigate the molecular mechanisms of tumor development and progression in multiple signaling pathways. Our current projects include 1) identifying the cancer-causing genes, targets, and pathways; 2) determining the genetic mechanism of tumor invasion and metastasis; 3) establishing the principle of tumor suppressors relay between FOXP3 and noncoding RNA; 4) developing human-like animal models of prostate cancer.

Selected Publications  Publication PUBMEDID 1. Wang L, Lin S, Rammohan KW, Liu Z, Liu JQ, LiuRH, Guinther N, Lima J, Zhou Q, Wang T, Zheng X, Birmingham DJ, Rovin BH, Hebert LA, Wu Y, Lynn DJ, Cooke G, Yu CY, Zheng P, Liu Y. A Di-nucleotide Deletion in CD24 Confers Protection against Autoimmune Diseases. PLoS Genetics, 2007 Apr 6;3(4):508-17. 2. Zuo T, Wang L, Morrison C, Chang X, Zhang H, Li W, Liu Y, Wang Y, Liu X, Chan MWY, Liu JQ, Love R, Liu CG, Godfrey V, Shen R, Huang THM, Yang T, Park BK, Wang CY, Zheng P, Liu Y. FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene. Cell, 2007 June 29; 129 (7): 1275-86. 3. Liu R, Wang L, Chen C, Liu Y, Zhou P, Wang Y, Wang X, Turnbull J, Minassian BA, Liu Y, Zheng P. Laforin negatively regulates cell cycle progression through GSK-3{beta} dependent mechanisms. Mol Cell Biol. 2008 Dec; 28 (23):7236-44. 4. Liu R, Wang L, Chen C, Katoh H, Chen C, Zheng P, Liu Y. FOXP3 up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/4 association to the locus. Cancer Res. 2009 Mar 15; 69 (6): 2252-9. 5. Wang L, Liu R, Li W, Chen C, Katoh H, Chen GY, McNally B, Lin L, Zhou P, Zuo T, Cooney KA, Liu Y, Zheng P. Somatic Single-hits Inactivate the X-linked Tumor Suppressor FOXP3 in the Prostate. Cancer Cell, 2009 Oct 6; 16 (4):336-46. 6. Wang L, Liu R, Ribick M, Zheng P, Liu Y. FOXP3 as an X-linked tumor suppressor. Discov Med. 2010 Oct; 10 (53): 322-8. 7. Li W, Wang L, Katoh H, Liu R, Zheng P, Liu Y. Identification of a tumor suppressor relay between the FOXP3 and the Hippo pathways in breast and prostate cancers. Cancer Res. 2011 Mar 15; 71 (6): 2162-71. 8. Liu R, Kain M, Wang L*. Inactivation of X-linked tumor suppressor genes in human cancer. Future Oncology. . 2012 Apr;8(4):463-81.   http//wwwncbinlmnihgov/pubmed?term=lizhong%20

Keywords Tumor Suppressor Gene, Tumor Development and Progression, Cancer Genetics

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