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Faculty Detail     Name CATHERINE M FULLER   Campus Address MCLM 830 Zip 0005 Phone 205-934-6227 E-mail cfuller@uab.edu Other websites

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Associate Professor Secondary  Cell Biology   Cell Biology Associate Professor Center  Ctr for Glial Bio in Med  Ctr for Glial Bio in Med Associate Professor Center  Cystic Fibrosis Research Center  Cystic Fibrosis Research Center Associate Professor Center  Medicine  Nephrology Res & Trng Ctr Associate Professor

Graduate Biomedical Sciences Affiliations Cancer Biology  Integrative Biomedical Sciences  Medical Scientist Training Program  Neuroscience  Pathobiology and Molecular Medicine

Biographical Sketch  Cathy Fuller, Ph.D. (Associate Professor), received her B.Sc. (Hons.) degree from the University of London (1982), and her Ph.D. from the University of Liverpool (1985), in the laboratory of Prof. O.H. Petersen. She was a post-doctoral fellow in the laboratory of Dr. I. Schulz at the Max Planck Institut fur Biophysik (Frankfurt, Germany), from 1985-1988. She joined the Dept. of Physiology and Biophysics as a post-doctoral fellow in the laboratory of Dr. Dale J. Benos in 1988. She joined the faculty of the department in 1995.

Society Memberships Organization Name Position Held Org Link American Physiological Society  Steering Committee, Cell and Molecular Physiology Section  www.the-aps/org

Research/Clinical Interest Title ENaC/ASIC Ion Channels; Description My lab is interested in the molecular mechanisms underlying the function of epithelial and astrocyte Na+ channels. These cell membrane proteins have important roles to play in the regulation of whole-body salt and water homeostasis, as well as in cell migration and proliferation in disease states such as cancer and renal disease. Current projects in the lab include analysis of ASIC/ENaC family members and their interaction with MAPK/ERK signaling pathways with relevance to migration and proliferation in gliomas, trafficking of these channel subunits in gliomas and their role in lipid rafts, and the role of a novel ENaC/ASIC chnnel in polycystic kidney disease. We use techniques such as fluorescence imaging, RT-PCR, site-directed mutagenesis and electrophysiology.

Selected Publications  Publication PUBMEDID Kapoor, N., Lee, W., Clark, E, Bartoszewski, R., McNicholas, C.M., Latham, C., Bebok, Z., Parpura, V., Fuller, C.M., Palmer, C., Benos, D.J. Acidosis increases ASIC1 plasma membrane expression in glioblastoma multiforme. Am. J. Physiol. Cell Physiol. 300: C1246-C1259, 2011. Selected for “Highlights from the Literature” Editorial Section in Physiology   21346156  Clark, E.B., Jovov, B., Rooj, A.K., Fuller, C.M., and Benos, D.J. Proteolytic cleavage of the human acid-sensing ion channel 1 by the serine protease matriptase. J. Biol. Chem. 285:27130-27143, 2010.  20601429  Qadri, Y.J., Y. Song, C.M. Fuller, and D.J. Benos. Amiloride docking to acid-sensing ion channel 1. J. Biol. Chem. 285:9627-9635, 2010.  20048170  Kapoor, N., R. Bartoszewski, Y.J. Qadri, Z. Bebok, J.K. Bubien, C.M. Fuller, and D.J. Benos. Knockdown of ASIC1 and ENaC subunits inhibits glioblastoma whole cell current and cell migration. J. Biol. Chem. 284:24526-24541, 2009.  19561078  Qadri, Y.J., B.K. Berdiev, Y. Song, H.L. Lippton, C.M. Fuller, and D.J. Benos. Psalmotoxin-1 docking to human acid-sensing ion channel 1. J. Biol. Chem. 284: 17625-17633, 2009.  19395383  Bashari, E., Y.J. Qadri, Z.H. Zhou, N. Kapoor, S.J. Anderson, R.H. Meltzer, C.M. Fuller and D.J. Benos. Two PKC consensus sites on human acid-sensing ion channel 1b differentially regulate its function. Am. J. Physiol. 296: C372-C384, 2008.  19091960  Vila-Carriles, W., Z.-H. Zhou, C.M. Fuller, and D.J. Benos. Participation of the chaperone Hsc70 in the trafficking and functional expression of ASIC2 in glioma cells. J. Biol. Chem (2007) 282:34381-34391  17878160  Ross, S.B. C.M. Fuller, J.K. Bubien, and D.J. Benos. Amiloride and psalmotoxin-sensitive Na+ channels contribute to regulatory volume increases in high grade glioma cells. Am. J. Physiol. Cell Physiol. (2007) 293:C1181-C1185.   17615161   Meltzer, R.H., N. Kapoor, Y.J. Qadri, S.J. Anderson, C.M. Fuller and D.J. Benos. Heteromeric assembly of ASIC and ENaC subunits in glioma. (2007) J. Biol. Chem. 282:25548-25559.  17613525  Vila-Carriles, W., G. Gy. Kovacs. Y. Qadri, B. Jovov, Z.-H. Zhou, A.K. Pahwa, G. Colby, O. Esimai, G.Y. Gillespie, T.B. Mapstone, J.M. Markert, C.M. Fuller, J.K. Bubien, and D.J. Benos, Surface expression of ASIC2 inhibits the amiloride sensitive current and migration of glioma cells (2006) J. Biol. Chem. 281, 19220-32  16704974   First Prev   1 2 of  2  Next Last

Keywords Sodium channels, glioma, migration, proliferation, cancer, signaling, polycystic kidney disease

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