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Faculty Detail     Name CARMEL M MCNICHOLAS-BEVENSEE   Campus Address MCLM 868 Zip 0005 Phone 205-934-1785 E-mail cbevense@uab.edu Other websites

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Instructor Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Instructor

Graduate Biomedical Sciences Affiliations Integrative Biomedical Sciences  Pathobiology and Molecular Medicine

Biographical Sketch  Dr. Carmel McNicholas-Bevensee, Instructor, received both her B.Sc. (Hons) degree (1989) and Ph.D. (1992) from the University of Manchester (England). After completing her postdoctoral training in the Department of Cellular and Molecular Physiology at Yale University in the laboratory of Dr. Gerhard Giebisch, she worked as Research Investigator II for Bristol-Myers Squibb Pharmaceutical Research Institute. She joined the UAB faculty in 2000.

Research/Clinical Interest Title Regulation of ion channels of the pulmonary and cardiovascular systems Description My research interest focuses on the regulation and biophysical characterization of ion channels. My research focuses on the impact of inflammation and tissue remodeling on the electrophysiological profile of cardiac myocytes and airway cells. Studies include examining the effect and underlying causes of cellular electrophysiological changes in the failing heart and the effects of release of inflammatory mediators on CFTR ion channel function in airway cells.

Selected Publications  Publication PUBMEDID Kapoor, N., Lee, W., Clark, E., Bartoszewski, R., McNicholas, C.M., Latham, C.B., Bebok, Z., Parpura,V., Fuller,C.M., Palmer, C.A. and Benos, D.J. Interaction of ASIC1 and ENaC subunits in human glioma cells and rat astrocytes. Am J Physiol Cell Physiol 300: C1246-1259, 2011.  21346156  McNicholas, C.M., Berecek, K.H. Mammalian target of rapamycin: MasTOR mediator of cellular changes in pathological states? Hypertension 54 (6):1221-2, 2009  19884561  Wu, J., McNicholas, C.M., & Bevensee M.O. Phosphatidylinositol 4,5-bisphosphate (PIP2) stimulates the electrogenic Na/HCO3 cotransporter NBCe1-A expressed in Xenopus oocytes. Proc Natl Acad Sci U S A 106 (33):14150-5, 2009.   19667194  McNicholas-Bevensee, C.M., DeAndrade, K.B., Bradley, W.E., Dell'Italia, L.J., Lucchesi, P.A. and Bevensee, M.O. Activation of gadolinium-sensitive ion channels in cardiomyocytes in early adaptive stages of volume overload-induced heart failure. Cardiovasc Res 72: 262-270, 2006.  16959228  McAlear, S.D., Liu, X., Williams, J.B., McNicholas-Bevensee, C.M. & Bevensee M.O. Electrogenic Na/HCO3 cotransporter (NBCe1) variants expressed in Xenopus oocytes: functional comparison and roles of the amino and carboxy termini. J Gen Physiol 127: 639-658, 2006.  16735752  Hickman-Davis, J.M., McNicholas-Bevensee, C., Davis, I.C., Ma, H.P., Davis, G.C., Bosworth, C.A. & Matalon S. Reactive species mediate inhibition of alveolar type II sodium transport during mycoplasma infection. Am J Respir Crit Care Med 173: 334-344, 2006.  16254273  Hardiman, K.M., McNicholas-Bevensee, C.M. Fortenberry, J., Malik, B., Eaton, D. & Matalon, S. Regulation of amiloride-sensitive lung Na+ transport in lung epithelia by basal nitric oxide. Am J Respir Cell Mol Biol. 30 (5), 720-8, 2004.  14607816  Peter, K., Varga, K., Bebok, Z., McNicholas-Bevensee, C.M., Schwiebert, L., Sorscher, E.J., Schwiebert, E.M. & Collawn, J.F. Ablation of internalization signals in the carboxyl-terminal tail of the cystic fibrosis transmembrane conductance regulator enhances cell surface expression. J Biol Chem, 277 (51), 49952-49957, 2002.  12376531  McNicholas, C.M., Nason, Jr. M.W., Guggino W.B., Schwiebert, E.M., Hebert, S.C., Giebisch, G. & Egan, M.E. A functional CFTR-NBF1 is required for ROMK2-CFTR interaction. Am J Physiol Renal Physiol 273, F843-F848, 1997.  9374850  McNicholas, C.M., Guggino, W.B., Schwiebert, E.M., Hebert, S.C., Giebisch, G., and Egan, M.E. Sensitivity of a renal K+ channel (ROMK2) to the inhibitory sulfonylurea compound, glibenclamide, is enhanced by co-expression with the ATP-binding cassette transporter CFTR. Proc Natl Acad Sci U S A, 93, 8083-8088, 1996.   8755607  First Prev   1 2 of  2  Next Last

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