Back to Main

Faculty Detail    
Name SHIH-HSIN YANG
  
Campus Address 176F 2232 Zip 6832
Phone 205-934-5670
E-mail eyang@uab.edu
Other websites http://www.uab.edu/radonc/profiles/eddy_yang.php
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Radiation Oncology   Radiation Oncology Chair Office Assistant Professor
Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Assistant Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Assistant Professor

Graduate Biomedical Sciences Affiliations
Cancer Biology 
Cell, Molecular, & Developmental Biology 
Neuroscience 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Please see the link above.

Research/Clinical Interest
Title
Targeting DNA repair pathways to augment the therapeutic ratio for cancer patients
Description
We aim to inhibit DNA repair pathways to enhance tumor susceptibility to DNA damage. In particular, we have been investigating the role of the epidermal growth factor receptor (HER/EGFR) family in DNA damage and repair. Additionally, we are interested in the protection of hippocampal neurons from radiation induced apoptosis by increasing DNA repair capacity in irradiated neurons through inhibition of GSK3beta.

Selected Publications 
Publication PUBMEDID
DNA damage-induced cytotoxicity is dissociated from BRCA1's DNA repair function but is dependent on its cytosolic accumulation.
Wang H, Yang ES, Jiang J, Nowsheen S, Xia F.
Cancer Res. 2010 Aug 1;70(15):6258-67. Epub 2010 Jul 14. 		 21398658 
Glycogen synthase kinase 3{beta} inhibition enhances repair of DNA double-strand breaks in irradiated hippocampal neurons.
Yang ES, Nowsheen S, Wang T, Thotala DK, Xia F.
Neuro Oncol. 2011 Mar 11.  		 20631074 
BRCA1 16 years later: DNA damage-induced BRCA1 shuttling.
Yang ES, Xia F.
FEBS J. 2010 Aug;277(15):3079-85. Epub 2010 Jul 1. 		 20608971 
Reduction of dose delivered to organs at risk in prostate cancer patients via image-guided radiation therapy.
Pawlowski JM, Yang ES, Malcolm AW, Coffey CW, Ding GX.
Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3):924-34. Epub 2009 Dec 11. 		 20004528 
Refractory lympho-epithelial carcinoma of the nasopharynx: a case report illustrating a protracted clinical course.
Wu FY, Yang ES, Willey CD, Ely K, Garrett G, Cmelak AJ.
Head Neck Oncol. 2009 Jun 15;1:18. 		 19527509 
Lithium-mediated protection of hippocampal cells involves enhancement of DNA-PK-dependent repair in mice.
Yang ES, Wang H, Jiang G, Nowsheen S, Fu A, Hallahan DE, Xia F.
J Clin Invest. 2009 May;119(5):1124-35. 		 19425167 
Erlotinib attenuates homologous recombinational repair of chromosomal breaks in human breast cancer cells.
Li L, Wang H, Yang ES, Arteaga CL, Xia F.
Cancer Res. 2008 Nov 15;68(22):9141-6. 		 19010885 
Evolution of clinical trials in head and neck cancer.
Yang ES, Murphy BM, Chung CH, Netterville JL, Burkey BB, Gilbert J, Yarbrough WG, Sinard R, Cmelak AJ.
Crit Rev Oncol Hematol. 2009 Jul;71(1):29-42. Epub 2008 Nov 7. 		 18996026 
The role of mTOR inhibition in augmenting radiation induced autophagy.
Jaboin JJ, Shinohara ET, Moretti L, Yang ES, Kaminski JM, Lu B.
Technol Cancer Res Treat. 2007 Oct;6(5):443-7.  		 17877432 
Autophagy signaling in cancer and its potential as novel target to improve anticancer therapy.
Moretti L, Yang ES, Kim KW, Lu B.
Drug Resist Updat. 2007 Aug-Oct;10(4-5):135-43. Epub 2007 Jul 12.  		 17627865 
First Prev   1 2 of  2  Next Last  

Keywords
DNA damage, DNA repair, EGFR, cancer, PARP, apoptosis, brain, protection, GSK3

© 2008 University of Alabama at Birmingham. All rights reserved. DisclaimerAbout this SiteGraphic Design Created by UAB Web Communications.
Calendar Designed by Medical Education Information Services. To report problems with the site, email us at meis@uab.edu. Last Revision: February 15, 2012.
The UAB School of Medicine Mailing Address: 1530 3rd Avenue South, FOT 1203, Birmingham AL 35294-3412