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Faculty Detail    
Name SHIH-HSIN YANG
 
Campus Address 176F 2232 Zip 6832
Phone 205-934-5670
E-mail eyang@uab.edu
Other websites http://www.uab.edu/medicine/radonc/en/faculty2/eddy-yang-md-phd
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Radiation Oncology   Radiation Oncology Chair Office Associate Professor
Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Associate Professor
Secondary  Pharmacology/Toxicology   Pharmacology/Toxicology Chair's Office Associate Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Associate Professor

Graduate Biomedical Sciences Affiliations
Cancer Biology 
Cell, Molecular, & Developmental Biology 
Neuroscience 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Please see the link above.

Research/Clinical Interest
Title
Targeting DNA repair pathways to augment the therapeutic ratio for cancer patients
Description
We are interested in the molecular pathways that could be targeted for cancer therapies. To address our interests, we have recently acquired the Nanostring nCounter platform which performs targeted gene expression, microRNA, protein, and/or other profiling. This will allow the discovery of tumor subtypes and prognostic signatures to effect patient therapies. Additionally, we aim to inhibit DNA repair pathways to enhance tumor susceptibility to DNA damage. In particular, we have been investigating the role of the epidermal growth factor receptor (HER/EGFR) family in DNA damage and repair. Additionally, we are interested in the protection of hippocampal neurons from radiation induced apoptosis by increasing DNA repair capacity in irradiated neurons through inhibition of GSK3beta.

Selected Publications 
Publication PUBMEDID
DNA damage-induced cytotoxicity is dissociated from BRCA1's DNA repair function but is dependent on its cytosolic accumulation.
Wang H, Yang ES, Jiang J, Nowsheen S, Xia F.
Cancer Res. 2010 Aug 1;70(15):6258-67. Epub 2010 Jul 14. 
21398658 
Glycogen synthase kinase 3{beta} inhibition enhances repair of DNA double-strand breaks in irradiated hippocampal neurons.
Yang ES, Nowsheen S, Wang T, Thotala DK, Xia F.
Neuro Oncol. 2011 Mar 11.  
20631074 
BRCA1 16 years later: DNA damage-induced BRCA1 shuttling.
Yang ES, Xia F.
FEBS J. 2010 Aug;277(15):3079-85. Epub 2010 Jul 1. 
20608971 
Reduction of dose delivered to organs at risk in prostate cancer patients via image-guided radiation therapy.
Pawlowski JM, Yang ES, Malcolm AW, Coffey CW, Ding GX.
Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3):924-34. Epub 2009 Dec 11. 
20004528 
Refractory lympho-epithelial carcinoma of the nasopharynx: a case report illustrating a protracted clinical course.
Wu FY, Yang ES, Willey CD, Ely K, Garrett G, Cmelak AJ.
Head Neck Oncol. 2009 Jun 15;1:18. 
19527509 
Lithium-mediated protection of hippocampal cells involves enhancement of DNA-PK-dependent repair in mice.
Yang ES, Wang H, Jiang G, Nowsheen S, Fu A, Hallahan DE, Xia F.
J Clin Invest. 2009 May;119(5):1124-35. 
19425167 
Erlotinib attenuates homologous recombinational repair of chromosomal breaks in human breast cancer cells.
Li L, Wang H, Yang ES, Arteaga CL, Xia F.
Cancer Res. 2008 Nov 15;68(22):9141-6. 
19010885 
Evolution of clinical trials in head and neck cancer.
Yang ES, Murphy BM, Chung CH, Netterville JL, Burkey BB, Gilbert J, Yarbrough WG, Sinard R, Cmelak AJ.
Crit Rev Oncol Hematol. 2009 Jul;71(1):29-42. Epub 2008 Nov 7. 
18996026 
The role of mTOR inhibition in augmenting radiation induced autophagy.
Jaboin JJ, Shinohara ET, Moretti L, Yang ES, Kaminski JM, Lu B.
Technol Cancer Res Treat. 2007 Oct;6(5):443-7.  
17877432 
Autophagy signaling in cancer and its potential as novel target to improve anticancer therapy.
Moretti L, Yang ES, Kim KW, Lu B.
Drug Resist Updat. 2007 Aug-Oct;10(4-5):135-43. Epub 2007 Jul 12.  
17627865 
Deregulation of the Rho GTPase, Rac1, suppresses cyclin-dependent kinase inhibitor p21(CIP1) levels in androgen-independent human prostate cancer cells.
Knight-Krajewski S, Welsh CF, Liu Y, Lyons LS, Faysal JM, Yang ES, Burnstein KL.
Oncogene. 2004 Jul 15;23(32):5513-22. 
15077174 
Vitamin D inhibits G1 to S progression in LNCaP prostate cancer cells through p27Kip1 stabilization and Cdk2 mislocalization to the cytoplasm.
Yang ES, Burnstein KL.
J Biol Chem. 2003 Nov 21;278(47):46862-8. Epub 2003 Sep 3. 
12954644 
Vitamin D-mediated growth inhibition of an androgen-ablated LNCaP cell line model of human prostate cancer.
Yang ES, Maiorino CA, Roos BA, Knight SR, Burnstein KL.
Mol Cell Endocrinol. 2002 Jan 15;186(1):69-79. 
11850123 
Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis.
De Marzo AM, Marchi VL, Yang ES, Veeraswamy R, Lin X, Nelson WG.
Cancer Res. 1999 Aug 15;59(16):3855-60. 
10463569 

Keywords
nanostring, profiling, DNA damage, DNA repair, EGFR, cancer, PARP, apoptosis, brain, protection, GSK3