Back to Main

Faculty Detail     Name GWENDALYN D KING   Campus Address SHEL 913 Zip 2182 Phone 205-996-6247 E-mail gdking@uab.edu Other websites http://neurobiology-uab.infomedia.com/bios.asp?action=form&recordID=515139

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Neurobiology  Neurobiology Assistant Professor Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Assistant Professor Center  Center for Aging  Center for Aging Assistant Professor Center  Civitan International Research Center  Civitan International Research Center Assistant Professor Center  Ctr for Glial Bio in Med  Ctr for Glial Bio in Med Assistant Professor

Graduate Biomedical Sciences Affiliations Cancer Biology  Cell, Molecular, & Developmental Biology  Neuroscience  Pathobiology and Molecular Medicine

Biographical Sketch  BS, Purdue University MS, Ph.D. University of Michigan Postdoctoral Fellow, Cedars-Sinai Medical Center/UCLA Instructor, Boston University School of Medicine

Research/Clinical Interest Title Role of Klotho in aging and the brain Description We are interested in understanding the differences between normal and pathological brain aging. Present studies are focused on dissecting the role of Klotho in the brain and in the aging process. We are examining regulation of gene expression pre and post-transcriptional, protein distribution, localization and function in the brain, and Klotho's role in glioma.

Selected Publications  Publication PUBMEDID Muhammad AKM, Candolfi M, King GD, Yagiz K, Foulad D, Mineharu Y, Kroeger KM, Treuer KA, Nichols WS, Sandersen NS, Yang J, Khayznikof, M, Van Rooijen N, Lowenstein PR, Castro MG. Antiglioma Immunological Memory in Response to Conditional Cytotoxic/Immune Stimulatory Gene Therapy: Humoral and Cellular Immunity Lead to Tumor Regression. Clinical Cancer Research (2009) 15(19):6113-6127  19789315  King GD, Muhammad AKM, Xiong W, Kroeger KM, Puntel M, Larocque D, Palmer D, Ng P, Lowenstein PR, Castro MG. High-capacity adenoviral vector-mediated anti-glioma gene therapy in the presence of systemic anti-adenovirus immunity. Journal of Virology (2008) 82(9):4680-4.   18287240  King GD, , Kroeger KM, Bresee CJ, Candolfi M, Liu C, Manalo CM, Muhammad AKM, Pechnick RN, Lowenstein PR, Castro MG. Flt3L in combination with HSV1-TK- mediated gene therapy reverses brain tumor-induced behavioral deficits. Molecular Therapy (2008) 16(4):682-90.   18283279  King GD, Muhammad AKM, CurtinJF, Barcia C, Puntel M, Liu C, Candolfi M, Honig SB, Mondkar S, Lowenstein PR, Castro MG. Flt3L and HSV1-TK eradicate multifocal glioma in a syngeneic glioblastoma model. Neuro-oncology; (2008) 10(1):19-31.   18079358  Curtin JF, King GD, Barcia C, Liu C, Hubert FX, Guillonneau C, Josien R, Anegon I, Lowenstein PR, Castro MG. Flt3 ligand recruits plasmacytoid dendritic cells to the brain. Journal of Immunology (2006) 176: 3566 – 3577.   16517725  King GD*, Curtin JF*, Candolfi M, Kroeger K, Lowenstein PR, Castro MG. Gene Therapy and Targeted Toxins for Glioma. Current Gene Therapy (2005) 5:535-557. PMID:   16457645  Curtin JF*, King GD*, Candolfi M, Greeno RB, Kroeger KM, Lowenstein PR, Castro MG. Combining cytotoxic and immune-mediated gene therapy to treat brain tumors. Current Topics in Medicinal Chemistry (2005) 5(12):1151-70.   16248789  Ali S*, King GD*, Curtin JF, , Xiong W, Puntel M, Liu C, Cheng Q, Prieto J, Lassmann H, Lowenstein PR, Castro MG. Combined immune-stimulation and conditional cytotoxic gene therapy provide long-term survival in a macroscopic glioma model. Cancer Research, (2005) 65 (16) :7194-204.   16103070  King GD, Cherian K, Turner RS. X11α impairs γ- but not β-secretase cleavage of Amyloid Precursor Protein. Journal of Neurochemistry, (2005) 88 (4):971-82.   14756819  King GD, Turner RS. Adaptor protein interactions: modulators of Amyloid Precursor Protein metabolism and Alzheimer’s disease risk? Experimental Neurology. (2004)185: 208-19.   14736502  First Prev   1 2 of  2  Next Last

Keywords age, brain, klotho, glioma, molecular biology

© 2008 University of Alabama at Birmingham. All rights reserved. DisclaimerAbout this SiteGraphic Design Created by UAB Web Communications.
Calendar Designed by Medical Education Information Services. To report problems with the site, email us at meis@uab.edu. Last Revision: February 15, 2012.
The UAB School of Medicine Mailing Address: 1530 3rd Avenue South, FOT 1203, Birmingham AL 35294-3412