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Faculty Detail     Name MARTIN E YOUNG   Campus Address ZRB 308 Zip 0007 Phone 205-934-2328 E-mail meyoung@uab.edu Other websites

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Medicine  Med - Cardiovascular Disease Associate Professor Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Associate Professor Center  Medicine  Comprehensive Diabetes Ctr Associate Professor Center  Cell, Developmntl, & Integrative Biology  Ctr for Exercise Medicine Associate Professor Center  Medicine  Ctr Cardiovasc Bio Associate Professor

Biographical Sketch  Training University of Oxford, U.K. 1991 - 1995 M.Biochem. (BS and MS in Biochemistry) University of Oxford, U.K. 1995 - 1998 Diabetes/Metabolism D.Phil. Boston University 1998 - 1999 Diabetes/Metabolism Post-doctoral Fellowship University of Texas-Houston (UT-Houston) 1999 - 2001 Heart/Metabolism Post-doctoral Fellowship Positions and Employment 1996-1998 Oriel College Metabolism Lecturer, University of Oxford, U.K. 1998-1999 NIH Post-Doctoral Fellowship, Boston University 1999-2001 NIH Post-Doctoral Fellowship, UT-Houston 2001-2002 Assistant Professor of Medicine (Research Track), Department of Internal Medicine, UT-Houston 2001-2005 Faculty Cross Appointment with the Department of Biochemistry and Molecular Biology, UT-Houston 2002-2005 Assistant Professor of Molecular Medicine, Institute of Molecular Medicine, UT-Houston 2005-2009 Assistant Professor of Pediatrics, Children’s Nutrition Research Center, Baylor College of Medicine 2009-Present Associate Professor of Medicine, Department of Medicine, University of Alabama at Birmingham Other Experience and Professional Memberships 1996-1998 Tutoring of undergraduates (Biochemistry and Medical students) from Jesus, Oriel and St. Hughes Colleges, University of Oxford, U.K. 2001-2005 Conference Leader (Medical student teaching), Department of Biochemistry and Molecular Biology, UT-Houston 2003-2005 Biochemistry Lecturer, Medical School, UT-Houston 2002-2007 Member, American Diabetes Association 2001-Present Member, American Heart Association Honors 1991-1995 Oriel College Scholar, University of Oxford, U.K. 2001 ISHR Best Poster Award 2001 ISHR Young Investigator Award 1st Runner-up 2009-Present Society for Heart and Vascular Metabolism, Treasurer/Secretary

Research/Clinical Interest Title Role of the Circadian Clock within the Heart Description Research in my laboratory is focused on identifying the role(s) of the circadian clock in both cardiac and skeletal muscle. Circadian clocks are intrinsically maintained molecular mechanisms that condition the cell to changes in its environment. These circadian clocks therefore confer a selective advantage by providing a mechanism for anticipation of change. We have recently characterized fully the circadian clock within both mammalian heart and skeletal muscle. The broad objective of my laboratory is therefore to test the hypothesis that the circadian clock within these muscle types synchronizes responsiveness of cardiac and skeletal muscle to diurnal variations in their environment. Impairment of this molecular mechanism would therefore result in an inability of these muscles to respond appropriately to the onset of such environmental influences (i.e. maladaptation). The primary humoral factors currently under investigation are nutrients, such as glucose and fatty acids. In the latter case, cardiac and skeletal muscle exhibit dramatic diurnal variations in their responsiveness to fatty acids. Failure to respond adequately to increased fatty acid availability will result in accumulation of intramyocellular fatty acid derivatives. The latter may play a significant role in the pathogenesis of insulin resistance, type II diabetes mellitus, and/or cardiomyopathy. To address this line of reasoning, we have recently generated two novel genetically manipulated mouse models in which the circadian clock is specifically impaired within cardiomyocytes or skeletal myocytes.

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