Back to Main

Faculty Detail    
Name EMMA PEREZ-COSTAS
 
Campus Address SC 865C Zip 0017
Phone 205-996-9374
E-mail epcostas@uab.edu
Other websites http://www.researchgate.net/profile/Emma_PEREZ-COSTAS/
http://goo.gl/V8rBR
http://community.frontiersin.org/people/EMMAPEREZ-COSTAS/22138
http://www.uab.edu/medicine/neurobiology/faculty/78-ecostas
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Psychiatry   Psych - Behavioral Neurobiology Assistant Professor
Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Assistant Professor
Secondary  Neurobiology  Neurobiology Assistant Professor
Secondary  Psychology  Psychology Assistant Professor
Center  General Clinical Research Center  Comprehensive Neuroscience Center Assistant Professor

Graduate Biomedical Sciences Affiliations
Neuroscience 

Biographical Sketch 
-Bachelor in Science, Biology (1996). University of Santiago de Compostela, Spain
-Master in Science, Cell Biology (1998). University of Santiago de Compostela, Spain.
-PhD, Cell Biology/Neuroscience (2002). University of Santiago de Compostela, Spain.
-Postdoctoral Fellow (2003-2006), Maryland Psychiatric Research Center. University of Maryland, School of Medicine.
-Faculty Instructor (2006-2007), Maryland Psychiatric Research Center. University of Maryland, School of Medicine.
-Assistant Professor (2007-present), University of Alabama at Birmingham.

Society Memberships
Organization Name Position Held Org Link
AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE  REGULAR MEMBER  http://www.aaas.org 
ASOCIACION DE BIOLOGOS DE GALICIA (Galcian Biologists Association)  REGULAR MEMBER  http://www.biologosdegalicia.org 
FACULTY FOR UNDERGRADUATE NEUROSCIENCE  REGULAR MEMBER  http://www.funfaculty.org 
SOCIETY FOR NEUROSCIENCE  REGULAR MEMBER  http://www.sfn.org 

Research/Clinical Interest
Title
ASSISTANT PROFESSOR
Description
-The dopaminergic mesocortical pathway and its impact in cortical function in neurological and neuropsychiatric disorders.
-Characterization of novel animal models for the study of human brain pathology.
-Adaptation or development of new histological techniques.
-Development of the mesodiencephalic dopaminergic system

Funded Research:
12/2010-11/2015 Principal Investigator (MPI), Neuropathology of Dopamine Systems in Schizophrenia, funded by National Institutes of Mental Health (RO1MH066123)

People in the Lab
-Matthew W. Rice, Graduate Student, email:stvanek@uab.edu
-Kristen L. Smith, Undergraduate Student, Neuroscience and Science and Technology Honors Programs, UAB. email: kls93@uab.edu Watch Kristen explaining some of her work in the lab: Kristen explains work LAB ALUMNI: -Iria Gonzalez-Dopeso Reyes, PhD: iriagonzalez@unav.es (currently Postdoctoral Researcher at University of Navarra, Spain) -Ryan P. Lee, Undergraduate Student, Neuroscience and Science and Technology Honors Programs, UAB. email: panthera@uab.edu

Selected Publications 
Publication PUBMEDID
Anadon R, Melendez-Ferro M, Perez-Costas E, Pombal MA, Rodicio MC (1998) Centrifugal fibers are the only GABAergic structures of the retina of the larval sea lamprey: an immunocytochemical study., Brain Research, 782 (1-2), 297-30  9519276 
Gandy JC, Melendez-Ferro M, Bijur GN, Van Leuven F, Roche JK, Lechat B, Devijver H, Demedts D, Perez-Costas E*, Roberts RC* (2013) Glycogen synthase kinase-Beta;(GSK3-B) expression in a mouse model of Alzheimer's disease: A light and electron microscopy study. Synapse. 2013 Feb 7. doi: 10.1002/syn.21642. [Epub ahead of print]
[*Co-corresponding authors] 
23390016 
Melendez-Ferro M, Rice MW, Roberts RC, Perez-Costas E (2012) Dual use of immunohistochemistry for film densitometry and light microscopy. J Neurosci Methods, 208(1):86-91  22579877 
Perez-Costas E, Melendez-Ferro M, Rice MW, Conley RR, Roberts RC (2012) Dopamine pathology in schizophrenia: Analysis of total and phosphorylated tyrosine hydroxylase in the substantia nigra. Front. Psychiatry 3:31. doi: 10.3389/fpsyt.2012.00031  22509170 
Rice MW, Roberts RC, Melendez-Ferro M, Perez-Costas E (2011) Neurochemical characterization of the tree shrew dorsal striatum. Frontiers in Neuroanatomy 2011;5:53.
 
21887131 
Perez-Costas E, Gandy JC, Melendez-Ferro M, Roberts RC, Bijur GN (2010). Light and electron microscopy study of glycogen synthase kinase-3beta in the mouse brain. PLoS One 5(1):e8911.  20111716 
Perez-Costas E, Melendez-Ferro M, Roberts RC (2010) Basal ganglia pathology in schizophrenia: dopamine connections and anomalies. Journal of Neurochemistry, 113(2):287-302  20089137 
Melendez-Ferro M, Perez-Costas E, Roberts RC (2009) A new use for long-term frozen brain tissue: Golgi impregnation. Journal of Neuroscience Methods, 176(2):72-7  18789970 
Abalo XM, Villar-Cheda B, Meléndez-Ferro M, Pérez-Costas E, Anadón R, Rodicio MC (2007) Development of the serotonergic system in the central nervous system of the sea lamprey., Journal of chemical neuroanatomy, 34 (1-2), 29-46  17485194 
Villar-Cervino V, Abalo XM, Villar-Cheda B, Melendez-Ferro M, Perez-Costas E, Holstein GR, Martinelli GP, Rodicio MC, Anadon R (2006) Presence of glutamate, glycine and GABA in the retina of the larval sea lamprey: a comparative immunohistochemical study of the classical neurotransmitters in the larval and postmetamorphic retinas, The Journal of Comparative Neurology, 499: 810-827  17048230 
Villar-Cheda B, Perez-Costas E, Melendez-Ferro M, Abalo XM, Rodriguez-Munoz R, Anadon R, Rodicio MC (2006) Cell proliferation of the forebrain and midbrain of the sea lamprey, The Journal of Comparative Neurology, 494: 986-1006  16385485 
Rodicio MC, Villar-Cervino V, Abalo XM, Villar-Cheda B, Melendez-Ferro M, Perez-Costas E, Anadon R (2005) Chemoarchitecture of the dorsal column of the larval sea lamprey, Brain Research Bulletin, 66 (536-540)  16144645 
Perez-Costas E, Melendez-Ferro M, Perez-Garcia CG, Caruncho HJ, Rodicio MC (2004) Reelin immunoreactivity in the adult sea lamprey brain, Journal of Chemical Neuroanatomy, 27 (7-21)  15036359 
Melendez-Ferro M, Perez-Costas E, Villar-Cheda B, Rodriguez-Munoz R, Anadon R, Rodicio MC (2003) Ontogeny of gamma-aminobutyric acid-immunoreactive neurons in the rhombencephalon and spinal cord of the sea lamprey., The Journal of Comparative Neurology, 464 (1), 17-35.  12866126 
Melendez-Ferro M, Perez-Costas E, Villar-Cheda B, Abalo XM, Rodriguez-Munoz R, Rodicio MC, Anadon R (2002) Ontogeny of gamma-aminobutyric acid-immunoreactive neuronal populations in the forebrain and midbrain of the sea lamprey., The Journal of Comparative Neurology, 446 (4), 360-76  11954035 
Villar-Cheda B, Perez-Costas E, Melendez-Ferro M, Manoel Abalo X, Rodriguez-Munoz R, Anadon R, Celina Rodicio M (2002) Proliferating cell nuclear antigen (PCNA) immunoreactivity and development of the pineal complex and habenula of the sea lamprey, Brain Research Bulletin, 57(3-4), 285-7.  11922973 
Perez-Costas E, Melendez-Ferro M, Santos Y, Anadon R, Rodicio MC, Caruncho HJ (2002) Reelin immunoreactivity in the larval sea lamprey brain., Journal of Chemical Neuroanatomy, 23 (3), 211-21  11861127 
Melendez-Ferro M, Villar-Cheda B, Manoel Abalo X, Perez-Costas E, Rodriguez-Munoz R, Degrip WJ, Yanez J, Rodicio MC, Anadon R (2002) Early development of the retina and pineal complex in the sea lamprey: comparative immunocytochemical study., The Journal of Comparative Neurology, 442 (3), 250-65  11774340 
Melendez-Ferro M, Perez-Costas E, Rodriguez-Munoz R, Gomez-Lopez MP, Anadon R, Rodicio MC (2001) GABA immunoreactivity in the olfactory bulbs of the adult sea lamprey Petromyzon marinus L., Brain Research, 893 (1-2), 253-60.  11223013 
Melendez-Ferro M, Perez-Costas E, Gonzalez MJ, Pombal MA, Anadon R, Rodicio MC (2000) GABA-immunoreactive internuclear neurons in the ocular motor system of lampreys., Brain Research, 855 (1), 150-7  10650142 
Melendez-Ferro M, Rice MW, Roberts RC, Perez-Costas E (2013) An accurate method for the quantification of cytochrome C oxidase in tissue sections. J Neurosci Methods. 2013 Jan 30. pii: S0165-0270(13)00030-7. doi: 10.1016/j.jneumeth.2013.01.010. [Epub ahead of print]  23376420 
Barksdale KA, Perez-Costas E, Gandy CG, Melendez-Ferro M, Roberts RC, Bijur GN (2010) Mitochondria viability in mouse and human postmortem brain. FASEB Journal, 24(9): 3590-9  20466876 
Perez-Costas E, Guidetti P, Melendez-Ferro M, Kelley JJ, Roberts RC (2008) Neuroleptics and animal models: feasibility of oral treatments monitored by plasma levels and receptor occupancy assays, The Journal of Neural Transmission,115(5):745-53  18193153 
Roberts RC, Perez-Costas E (2008) Ultrastructural localization of reelin. In: “Reelin glycoprotein: biology structure and roles” (1st Edition), USA, Fatemi SH (Ed), Springer-Verlag, ISBN: 978-0-387-76760-4. ISBN=9780387767604 [bookchapter; chapter 8]   
Perez-Costas E, Melendez-Ferro M, Roberts RC (2007) Microscopy techniques and the study of synapses In A. Mendez-Vilas, J. Diaz (eds), Modern Research and Educational Topics in Microscopy, 3rd edition, Badajoz, Spain, Formatex, ISBN=9788461194193 (Book Chapter)   

Keywords
neuroanatomy, neuropathology, dopamine systems, neurobiology, neuronal development, neurological disorders, neuropsychiatric disorders