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Faculty Detail    
Name MIGUEL MELENDEZ-FERRO
PhD
 
Campus Address SC 865A Zip 0017
Phone 205-996-9375
E-mail melendez@uab.edu
Other websites http://scholar.google.com/citations?user=ERhgq9wAAAAJ
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Psychiatry   Psych - Behavioral Neurobiology Assistant Professor
Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Assistant Professor
Center  General Clinical Research Center  Comprehensive Neuroscience Center Assistant Professor

Graduate Biomedical Sciences Affiliations
Neuroscience 

Biographical Sketch 
-B.Sc., University of Santiago de Compostela, Spain (Biology), 1995
-M.Sc., University of Santiago de Compostela, Spain (Cell Biology), 1998
-Ph.D., University of Santiago de Compostela, Spain (Cell Biology/Neurosciences), 2002
-Postdoctoral Fellow University of Santiago de Compostela (Spain), 2002
-Postdoctoral Fellow, Maryland Psychiatric Research Center, University of Maryland at Baltimore, 2003-2007
-Postdoctoral Employee, University of Alabama at Birmingham, 2007-2008

Society Memberships
Organization Name Position Held Org Link
American Association for the Advancement of Science (AAAS)  Member  http://www.aaas.org 
Colexio de Biologos de Galicia (Galician Association of Biologists)  Member  http://www.biologosdegalicia.org 
Faculty for Undergraduate Neuroscience (FUN)  Member  http://www.funfaculty.org 
Society for Neuroscience (SfN)  Member  http://www.sfn.org 

Research/Clinical Interest
Title
Description
-Mapping the pathogenesis of dopaminergic systems in neuropsychiatric disorders: A long running project in the lab is the study of dopamine synthesis anomalies in schizophrenia. Recently we have extended our study to other neuropsychiatric disorders (bipolar disorder and major depression). -Characterization of animal models for the study of striatal pathologies. We are in the process of studying the neurochemical composition and neuronal distribution of the tree shrew (Tupaia glis) striatum with the aim to find a suitable animal model for comparison with human striatum development. The tree shrew striatum shares the basic patterns of the human striatum, with a truly separated caudate and putamen nuclei but little has been done to know the exact neurochemical and neuronal composition of this animalís basal ganglia. -Adaptation or development of new histological techniques.

Selected Publications 
Publication PUBMEDID
Barksdale KA, Perez-Costas E, Gandy CG, Melendez-Ferro M, Roberts RC, Bijur GN (2010) Mitochondria viability in mouse and human postmortem brain. FASEB Journal, 24(9): 3590-9.  2466876 
Gandy JC, Melendez-Ferro M, Bijur GN, Van Leuven F, Roche JK, Lechat B, Devijver H, Demedts D, Perez-Costas E, Roberts RC (2013) Glycogen synthase kinase-3b(GSK3b) expression in a mouse model of Alzheimer's disease: A light and electron microscopy study. Synapse. doi: 10.1002/syn.21642. [Epub ahead of print]  23390016 
Melendez-Ferro M, Rice MW, Roberts RC, Perez-Costas E (2013) An accurate method for the quantification of cytochrome C oxidase in tissue sections. J Neurosci Methods. doi:pii: S0165-0270(13)00030-7. 10.1016/j.jneumeth.2013.01.010. [Epub ahead of print]  23376420 
Melendez-Ferro M, Rice MW, Roberts RC, Perez-Costas E. (2012) Dual use of immunohistochemistry for film densitometry and light microscopy. Journal of Neuroscience Methods. 208(1):86-91.  22579877 
Perez-Costas E, Melendez-Ferro M, Rice MW, Conley RR, Roberts RC. (2012) Dopamine pathology in schizophrenia: analysis of total and phosphorylated tyrosine hydroxylase in the substantia nigra. Frontiers in Psychiatry. 3:31.  22509170 
Rice MW, Roberts RC, Melendez-Ferro M, Perez-Costas E (2011) Neurochemical characterization of the tree shrew dorsal striatum. Frontiers in Neuroanatomy 2011;5:53.  21887131 
Perez-Costas E, Gandy JC, Melendez-Ferro M, Roberts RC, Bijur GN (2010). Light and electron microscopy study of glycogen synthase kinase-3beta in the mouse brain. PLoS One 5(1):e8911.  20111716 
Perez-Costas E, Melendez-Ferro M, Roberts RC (2010) Basal ganglia pathology in schizophrenia: dopamine connections and anomalies. Journal of Neurochemistry, 113(2):287-302.  20089137 
Guidetti P, Hoffman GE, Melendez-Ferro M, Albuquerque EX, Schwarcz R. (2007) Astrocytic localization of kynurenine aminotransferase II in the rat brain visualized by immunocytochemistry. Glia 55(1):78-92.  17024659 
Anadon R, Melendez-Ferro M, Perez-Costas E, Pombal MA, Rodicio MC (1998) Centrifugal fibers are the only GABAergic structures of the retina of the larval sea lamprey: an immunocytochemical study. Brain Research, 782 (1-2), 297-30.  9519276 
Melendez-Ferro M, Perez-Costas E, Roberts RC (2009) A new use for long-term frozen brain tissue: Golgi impregnation. Journal of Neuroscience Methods, 176(2):72-7.  18789970 
Perez-Costas E, Guidetti P, Melendez-Ferro M, Kelley JJ, Roberts RC (2008) Neuroleptics and animal models: feasibility of oral treatments monitored by plasma levels and receptor occupancy assays. The Journal of Neural Transmission, 115(5):745-53.  18193153 
Abalo XM, Villar-Cheda B, Meléndez-Ferro M, Pérez-Costas E, Anadón R, Rodicio MC (2007) Development of the serotonergic system in the central nervous system of the sea lamprey. Journal of Chemical Neuroanatomy, 34 (1-2), 29-46 pubmed  17485194 
Villar-Cervino V, Abalo XM, Villar-Cheda B, Melendez-Ferro M, Perez-Costas E, Holstein GR, Martinelli GP, Rodicio MC, Anadon R (2006) Presence of glutamate, glycine and GABA in the retina of the larval sea lamprey: a comparative immunohistochemical study of the classical neurotransmitters in larval and postmetamorphic retinas. The Journal of Comparative Neurology, 499: 810-827.   17048230 
Villar-Cheda B, Perez-Costas E, Melendez-Ferro M, Abalo XM, Rodriguez-Munoz R, Anadon R, Rodicio MC (2006) Cell proliferation of the forebrain and midbrain of the sea lamprey. The Journal of Comparative Neurology, 494: 986-1006 pubmed  16385485 
Rodicio MC, Villar-Cervino V, Abalo XM, Villar-Cheda B, Melendez-Ferro M, Perez-Costas E, Anadon R (2005) Chemoarchitecture of the dorsal column of the larval sea lamprey. Brain Research Bulletin, 66 (536-540).  16144645 
Perez-Costas E, Melendez-Ferro M, Perez-Garcia CG, Caruncho HJ, Rodicio MC (2004) Reelin immunoreactivity in the adult sea lamprey brain. Journal of Chemical Neuroanatomy, 27 (7-21).  15036359 
Melendez-Ferro M, Perez-Costas E, Villar-Cheda B, Rodriguez-Munoz R, Anadon R, Rodicio MC (2003) Ontogeny of gamma-aminobutyric acid-immunoreactive neurons in the rhombencephalon and spinal cord of the sea lamprey. The Journal of Comparative Neurology, 464 (1), 17-35.  12866126 
Melendez-Ferro M, Perez-Costas E, Villar-Cheda B, Abalo XM, Rodriguez-Munoz R, Rodicio MC, Anadon R (2002) Ontogeny of gamma-aminobutyric acid-immunoreactive neuronal populations in the forebrain and midbrain of the sea lamprey. The Journal of Comparative Neurology, 446 (4), 360-76.  11954035 
Villar-Cheda B, Perez-Costas E, Melendez-Ferro M, Manoel Abalo X, Rodriguez-Munoz R, Anadon R, Celina Rodicio M (2002) Proliferating cell nuclear antigen (PCNA) immunoreactivity and development of the pineal complex and habenula of the sea lamprey. Brain Research Bulletin, 57(3-4), 285-7.  11922973 
Perez-Costas E, Melendez-Ferro M, Santos Y, Anadon R, Rodicio MC, Caruncho HJ (2002) Reelin immunoreactivity in the larval sea lamprey brain. Journal of Chemical Neuroanatomy, 23 (3), 211-21.  11861127 
Melendez-Ferro M, Villar-Cheda B, Manoel Abalo X, Perez-Costas E, Rodriguez-Munoz R, Degrip WJ, Yanez J, Rodicio MC, Anadon R (2002) Early development of the retina and pineal complex in the sea lamprey: comparative immunocytochemical study. The Journal of Comparative Neurology, 442 (3), 250-65.  11774340 
Melendez-Ferro M, Perez-Costas E, Rodriguez-Munoz R, Gomez-Lopez MP, Anadon R, Rodicio MC (2001) GABA immunoreactivity in the olfactory bulbs of the adult sea lamprey Petromyzon marinus L. Brain Research, 893 (1-2), 253-60.  11223013 
Melendez-Ferro M, Perez-Costas E, Gonzalez MJ, Pombal MA, Anadon R, Rodicio MC (2000) GABA-immunoreactive internuclear neurons in the ocular motor system of lampreys. Brain Research, 855 (1), 150-7.  10650142 
Perez-Costas E, Melendez-Ferro M, Roberts RC (2007) Microscopy techniques and the study of synapses In A. Mendez-Vilas, J. Diaz (eds), Modern Research and Educational Topics in Microscopy, 3rd edition, Badajoz, Spain, Formatex, ISBN=9788461194193 (bookchapter) book access   

Keywords
dopamine, basal ganglia, substantia nigra, schizophrenia, mental disorders, neuroanatomy, neuroanatomical techniques