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Faculty Detail     Name FARAH D LUBIN Assitant Professor   Campus Address SHEL 1102 Zip 2182 Phone 205-996-6084 E-mail flubin@uab.edu Other websites www.lubinlab.com

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Neurobiology  Neurobiology Assistant Professor Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Assistant Professor Center  General Clinical Research Center  Comprehensive Neuroscience Center Assistant Professor Center  Ctr for Glial Bio in Med  Ctr for Glial Bio in Med Assistant Professor

Graduate Biomedical Sciences Affiliations Cellular and Molecular Biology Program  Neuroscience

Biographical Sketch  www.lubinlab.com Dr. Lubin received her undergraduate degree from Alabama State University in Montgomery, Alabama and her Ph.D. in Cell/Molecular Biology and Immunology from Binghamton University in Binghamton, New York. She has also worked as a research assistant at Memorial Sloan Kettering Cancer Center in New York. Dr. Lubin has completed two postdoctoral fellowships in Molecular Neuroscience at Baylor College of Medicine in Houston, Texas and most recently in the Department of Neurobiology at UAB. Dr. Lubin is a recipient of a Pathway to Independence Award from the National Institutes of Health (NIH/NIMH) and FASEB Award. She has coauthored numerous publications in various scientific journals. Her most recent publications in J. Neuroscience and Neuron gives insight not only into the cellular and molecular mechanisms underlying long-term memory, but also insights into the fundamental mechanisms that might be deranged in cognitive disorders. Dr. Lubin’s research is primarily directed towards characterizing the role of epigenetic mechanisms and signaling cascades that mediate the interaction of the NF-kB transcription factors to chromatin, and determining how they participate in the regulation of gene expression as they relate to learning and memory.

Research/Clinical Interest Title Molecular genetic mechanisms in learning and memory Description Dr. Lubin’s research interest is focused on understanding the cellular and molecular mechanisms underlying transcriptional regulation of genes in the nervous system to mediate cognition and how these mechanisms are altered with aging and cognitive disorders including epilepsy and Alzheimer’s disease. Currently, our research is directed at characterizing the role of epigenetic mechanisms, such as histone modifications, DNA methylation, and the interaction of the NF-kB signaling pathway with chromatin to determine how these molecular changes participate in the regulation of gene expression related to the normal process of learning and memory and how they are deranged with cognitive deficits.

Keywords Epigenetics, NF-kappa B signal transduction, gene transcription, neuroscience, learning and memory, epilepsy

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