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Faculty Detail    
Name STEVEN POGWIZD
 
Campus Address VH B140 Zip 0019
Phone 205-975-4710
E-mail spogwizd@uab.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Medicine  Med - Cardiovascular Disease Professor
Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Professor
Center  Arthritis & Musculoskeletal Diseases Center  Arthritis & Musculoskeletal Diseases Center Professor
Center  Cell, Developmntl, & Integrative Biology  Ctr for Exercise Medicine Professor

Graduate Biomedical Sciences Affiliations
Medical Scientist Training Program 

Biographical Sketch 
Steven M. Pogwizd was born in Chicago, Illinois in October 1955. He received a BA degree in chemistry from the University of Chicago in 1977 (Magna cum laude) and a MD from Washington University in 1981. After he completed his residency at Michael Reese Hospital, Chicago in 1984, he was a research fellow, clinical fellow, and attending physician at Barnes Hospital, Washington University School of Medicine in St. Louis from 1984-1998. He served as Assistant Professor of Medicine, Washington University, from 1989-1998. From 1998-2008 he served as Associate Professor of Medicine and then subsequently promoted to Professor, University of Illinois at Chicago. He joined the faculty of UAB in January 2008 as Professor of Medicine, Biomedical Engineering and Physiology & Biophysics. He is Associate Director of Research in the Division of Cardiovascular Disease. He was named the Featheringill Endowed Professor in Cardiac Arrhythmia Research.

Society Memberships
Organization Name Position Held Org Link
American Heart Association     
Biophysical Society     
Cardiac Electrophysiologic Society     
Heart Rhythm Society     
International Society for Heart Research     

Research/Clinical Interest
Title
Description
The mission of the Pogwizd lab is to define the electrophysiological and biochemical mechanisms underlying lethal arrhythmias in the setting of heart failure (HF). My interest in the mechanisms of ventricular tachycardia (VT) and ventricular fibrillation (VF) arose from my 3-dimensional cardiac mapping studies of VT and VF in the setting of myocardial ischemia (Pogwizd & Corr, Circulation Circ Res 1987;61,352-371, Circulation 1987;76:404-426, and Circ Res 1990;66:672-695). My work evolved to the area of HF with the development of a novel arrhythmogenic rabbit model of HF (Pogwizd, Circulation 1995;92:1034-1048). During a nearly one-year sabbatical in the laboratories of Drs. Donald Bers and Alan Samarel at Loyola University (1997-1998), I learned fluorescent imaging of cellular Ca and Na, patch clamping and molecular biology approaches that I have applied to my studies in experimental models of HF and in the failing human heart (Pogwizd et al, Circ Res 1999;85:1009-1019 and Circ Res 2001;88:1159-1167). More recently my work has expanded to the role of connexins, their phosphorylation and dephosphorylation (Ai & Pogwizd, Circ Res 2005;96:54-63: Ai et al, Card Res, in press 2009); adenoviral gene transfer (Ziolo et al, Circ Res 2005;96:815-817) and three-dimensional electrocardiographic imaging (Am J Physiol 2005;289:H2724-2732) along with continued studies of Ca handling, adrenergic stimulation and ion channel alterations in the failing heart (Circ Res. 2005;97:1314-1322, Circ Res 2007;101(8):802-810, deSantiago et al, Circ Res 2008;102(6):695-702, and Circ Res 2008;102:1389-1397).

Selected Publications 
Publication PUBMEDID
Li L, Jin Q, Dosdall DJ, Huang J, Pogwizd SM and Ideker RE. Activation becomes highly organized during long-duration ventricular fibrillation in canine hearts. Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H2046-53.   20382862  
Curran J, Brown KH, Santiago DJ, Pogwizd SM, Bers DM and Shannon TR. Spontaneous Ca waves in ventricular myocytes from failing hearts depend on Ca(2+)-calmodulin-dependent protein kinase II. J Mol Cell Cardiol. 2010 Jul;49(1):25-32.   20353795  
Rinne A, Kapur N, Molkentin JD, Pogwizd SM, Bers DM, Banach K and Blatter LA. Isoform- and tissue-specific regulation of the Ca(2+)-sensitive transcription factor NFAT in cardiac myocytes and heart failure. Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H2001-9.   20304816 
Han C, Liu C, Pogwizd SM and He B. Noninvasive three-dimensional cardiac activation imaging on a rabbit model. Conf Proc IEEE Eng Med Biol Soc. 2009;2009:3271-3.   19964067 
Ai X, Zhao W and Pogwizd SM. Connexin43 knockdown or overexpression modulates cell coupling in control and failing rabbit left ventricular myocytes. Cardiovasc Res. 2010 Mar 1;85(4):751-62.  19880431  
Ideker RE, Rogers JM, Fast V, Li L, Kay GN and Pogwizd SM. Can mapping differentiate microreentry from a focus in the ventricle? Heart Rhythm. 2009 Nov;6(11):1666-9.   19793684 
Ideker RE, Kong W and Pogwizd SM. Purkinje fibers and arrhythmias. Pacing Clin Electrophysiol. 2009 Mar;32(3):283-5.   19272054 
Han C, Liu Z, Zhang X, Pogwizd SM and He B. Noninvasive three-dimensional cardiac activation imaging from body surface potential maps: a computational and experimental study on a rabbit model. IEEE Trans Med Imaging. 2008 Nov;27(11):1622-30. PMC2701977   18955177 
Desantiago J, Ai X, Islam M, Acuna G, Ziolo MT, Bers DM and Pogwizd SM. Arrhythmogenic effects of beta2-adrenergic stimulation in the failing heart are attributable to enhanced sarcoplasmic reticulum Ca load. Circ Res. 2008 Jun 6;102(11):1389-97. PMC2585979   18467626 
Attin M, Ideker RE and Pogwizd SM. Mechanistic insights into ventricular arrhythmias from mapping studies in humans.Heart Rhythm. 2008 Jun;5(6 Suppl):S53-8. Epub 2008 Mar 27. Review. No abstract available. Erratum in: Heart Rhythm. 2008 Oct;5(10):1499. PMC2612125   18456203 
Bossuyt J, Helmstadter K, Wu X, Clements-Jewery H, Haworth RS, Avkiran M, Martin JL, Pogwizd SM and Bers DM. Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure. Circ Res. 2008 Mar 28;102(6):695-702.   18218981  
Han C, Liu Z, Liu C, Pogwizd SM and He B. Three-dimensional activation sequence imaging in a rabbit model. Conf Proc IEEE Eng Med Biol Soc. 2007;2007:5609-11.   18003284 
Allison SO, Artwoh JE, Fortman JD, Pogwizd SM, Jeanes J, Koske S, Pinkerton ME, Haschek WM and Messick J. Iatrogenic hemolytic anemia and endocarditis in New Zealand white rabbits secondary to Achromobacter xylosoxidans infection. J Am Assoc Lab Anim Sci. 2007 Nov;46(6):58-62.   17994675 
Guo T, Ai X, Shannon TR, Pogwizd SM and Bers DM. Intra-sarcoplasmic reticulum free [Ca2+] and buffering in arrhythmogenic failing rabbit heart. Circ Res. 2007 Oct 12;101(8):802-10. Epub 2007 Aug 17.   17704210  
Anghel TM and Pogwizd SM. Creating a cardiac pacemaker by gene therapy. Med Biol Eng Comput. 2007 Feb;45(2):145-55. Epub 2006 Dec 1. Review.   17139515  
Liu C, Zhang X, Liu Z, Pogwizd SM and He B. Three-dimensional myocardial activation imaging in a rabbit model. IEEE Trans Biomed Eng. 2006 Sep;53(9):1813-20.   16941837 
Lee PJ and Pogwizd SM. Micropatterns of propagation. Adv Cardiol. 2006;42:86-106. Review.   16646586 
Ai X, Curran JW, Shannon TR, Bers DM and Pogwizd SM. Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure. Circ Res. 2005 Dec 9;97(12):1314-22. Epub 2005 Nov 3.   16269653 
Bossuyt J, Ai X, Moorman JR, Pogwizd SM and Bers DM. Expression and phosphorylation of the na-pump regulatory subunit phospholemman in heart failure. Circ Res. 2005 Sep 16;97(6):558-65. Epub 2005 Aug 11.   16100047 
Zhang X, Ramachandra I, Liu Z, Muneer B, Pogwizd SM and He B. Noninvasive three-dimensional electrocardiographic imaging of ventricular activation sequence. Am J Physiol Heart Circ Physiol. 2005 Dec;289(6):H2724-32.   16085677