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Faculty Detail     Name WEI WANG   Campus Address MCLM 713 Phone 205-934-3653 E-mail weiwang@uab.edu Other websites

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Assistant Professor

Biographical Sketch  Dr. Wei Wang, Assistant Professor, received his B.S. in Sport Science from Shanghai Institute of Physical Education (1982), China. He earned his M.S. in Exercise Physiology at Tokyo Gakugei University (1990), and his Ph.D. in Physiology at Juntendo University (1996), Japan. After his postdoctoral training at the Georgetown Medical Center, Dr Wang served as a faculty member in the Department of Physiology at Juntendo University. He came to UAB in 2001 as a research fellow and joined the Department of Physiology and Biophysics in 2006.

Society Memberships Organization Name Position Held Org Link Biophysical Society

Research/Clinical Interest Title Regulation of the CFTR channel Description Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a chloride channel that controls salt and water transport across epithelia. Mutations of CFTR cause CF, an inherited disease among the Caucasian population. Dysfunction of CFTR channel in CF disrupts transport of fluid and electrolytes in epithelia and subsequently affects lung and digestive system. Dr. Wang’s research is focused on (i) the better understanding structure-function relationship of CFTR (ii) how disease-associated mutations cause channel dysfunction in order to develop therapeutic strategies against CF related diseases. Current research projects include (i) The mechanism of domain regulated CFTR channel gating, (ii) Mechanism of compounds induced channel activation and restoration of disease-associated mutant CFTR, (iii) Modulation of CFTR by oxidant stress.

Selected Publications  Publication PUBMEDID Wang W, Okeyo GO, Tao B, Hong JS, Kirk KL. Thermally unstable gating of the most common cystic fibrosis mutant channel (ΔF508): "rescue" by suppressor mutations in nucleotide binding domain 1 and by constitutive mutations in the cytosolic loops. J Biol Chem. 286(49):41937-48,2011.   21965669  Kirk K, Wang W. A unified view of CFTR gating: combining the allosterism of a ligand-gated channel with the enzymatic activity of an ABC transporter. J Biol Chem. 2011 Feb 4  21296873  Thibodeau PH, Richardson JM, Wang W, Millen L, Watson J, Mendoza JL, Du K, Fischman S, Senderowitz H, Lukacs GL, Kirk K, Thomas PJ. The cystic fibrosis-causing mutation {Delta}F508 affects multiple steps in CFTR biogenesis. J Biol Chem. 2010 Jul 28.  20667826  Wang, W. Wu J, Bernard K, Li G, Wang G, Bevensee M, Kirk KL. ATP-independent CFTR channel gating and allosteric modulation by phosphorylation. Proc Natl Acad Sci U S A. 107:3888-93, 2010.  20133716  Bernard K, Wang W, Narlawar R, Schmidt B, Kirk KL. Curcumin cross-links cystic fibrosis transmembrane conductance regulator (CFTR) polypeptides and potentiates CFTR channel activity by distinct mechanisms. J Biol Chem. 284(45):30754-65, 2009.  19740743  Wang W, Bernard K, Li G and Kirk K L. Curcumin opens CFTR channels by a novel mechanism that requires neither ATP binding nor dimerization of the nucleotide binding domains J Biol Chem. 282(7):4533-44, 2007.   17178710  Li, Y. Wang W, Parker W, Clancy JP. Adenosine Regulation of CFTR through Prostenoids in Airway Epithelia. Am J Respir Cell Mol Biol. 34(5):600-608 2006.  16399952  Wang W, Li G, Clancy JP, Kirk KL. Activating cystic fibrosis transmembrane conductance regulator channels with pore blocker analogs. J Biol Chem. 280(25):23622-30, 2005.  15857825  Wang W, Oliva C, Li G, Holmgren A, Lillig CH, Kirk KL. Reversible silencing of CFTR chloride channels by glutathionylation. J Gen Physiol. 125(2):127-41, 2005.  15657297  Wang W, Hino N, Yamasaki H, Aoki T, Ochi R. KV2.1 K+ channels underlie major voltage-gated K+ outward current in H9c2 myoblasts. Jpn J Physiol. 52(6):507-14, 2002.  12617756  First Prev   1 2 of  2  Next Last

Keywords CFTR, ion channel, electrophysiology

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