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Faculty Detail     Name SHAWN R GILBERT   Campus Address ACC 316 Zip 0011 Phone 205-975-7499 E-mail shawng@uab.edu Other websites

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Surgery   Surgery - Orthopaedic Associate Professor Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Associate Professor Secondary  Pathology   Molecular & Cellular Pathology Assistant Professor Center  Center for Metabolic Bone Disease  Center for Metabolic Bone Disease Associate Professor Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Associate Professor

Biographical Sketch  EDUCATION: University of North Carolina School of Medicine M.D. with Honors, 1996 University of North Carolina at Chapel Hill B.S. Biology with distinction and Highest Honors, 1992 AWARDS/HONORS: Vern Tolo Basic Science Paper Award - Recognizes outstanding basic science presentation at annual meeting of Pediatric Orthopaedic Society of North America, 2009. St. Giles Young Investigator Award – Awarded by Pediatric Orthopaedic Society of North America to a promising young investigator in the field of Pediatric Orthopaedics, 2009. Most outstanding teaching performance by a resident – Musculoskeletal course for second year medical students, UNC School of Medicine, 1998 POSTDOCTORAL TRAINING: 2002-2003 Fellowship, Pediatric Orthopaedic Surgery Children’s Healthcare of Atlanta 1996-2002 Residency, Orthopaedic Surgery UNC Hospitals Research track includes 15 months Lab)

Research/Clinical Interest Title Description I have two foci of basic science research. My principal interest has been investigating the role of the hypoxia inducible factor (HIF) pathway and angiogenesis in the skeleton. I am pursuing a line of investigation that angiogenesis drives osteogenesis, both during development and repair. I am using genetic mouse models and pharmacologic interventions to increase angiogenesis by targeting HIF. I have also identified additional HIF activating pro-angiogenic compounds that are under development. I have recently developed a new translational research interest in obesity and musculoskeletal health. I am pursuing both clinical studies and animal studies to examine musculoskeletal health (outcomes measures), injuries and mechanisms that predispose to injury or impair recovery. Additional clinical research interests include publications and presentations on limb and spine deformity, fractures, skeletal maturation, and musculoskeletal infections, and an ongoing randomized clinical trial comparing bracing styles for clubfeet.

Keywords HIF, angiogenesis, bone, obesity, fracture

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