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Faculty Detail     Name SUSAN L BELLIS   Campus Address MCLM 982A Zip 0005 Phone 205-934-3441 E-mail bellis@uab.edu Other websites

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Professor Secondary  Cell Biology   Cell Biology Associate Professor Center  Arthritis & Musculoskeletal Diseases Center  Arthritis & Musculoskeletal Diseases Center Professor Center  Pathology   Cell Adhesion & Matrix Research Center Professor Center  Center for Metabolic Bone Disease  Center for Metabolic Bone Disease Professor Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Professor Center  Medicine  Ctr Cardiovasc Bio Professor Center  Medicine  Gene Therapy Center Professor

Graduate Biomedical Sciences Affiliations Cancer Biology  Immunology  Integrative Biomedical Sciences  Medical Scientist Training Program  Pathobiology and Molecular Medicine

Biographical Sketch  I received a Ph.D. in Biochemistry from the University of Rhode Island in 1993. My postdoctoral research, performed at the SUNY Health Science Center in Syracuse, NY, was centered on understanding cell/matrix interactions. Since my arrival at UAB in 1998, I have continued to focus my research in the general area of cell adhesion and matrix biology.

Society Memberships Organization Name Position Held Org Link American Association for Cancer Research      American Society for Biochemistry and Molecular Biology      American Society for Cell Biology      American Society for Matrix Biology      Society for Biomaterials      Society for Glycobiology

Research/Clinical Interest Title Cell/matrix interactions in disease and tissue regeneration Description There are two principal projects in the Bellis laboratory: (1) Role of receptor glycosylation in regulating cell migration and survival. The addition of the negatively-charged sugar, sialic acid, to selected cell surface receptors has a significant impact on receptor function. Our laboratory has determined that the ST6Gal-I glycosyltransferase adds sialic acids to selected integrin and death receptors and thereby regulates cell adhesion, migration and apoptosis. Using cell model systems and genetically engineered mice, we have shown that ST6Gal-I-mediated sialylation controls integrin preference for matrix molecules, and also blocks apoptotic signaling from the Fas and TNFR1 death receptors. Collectively these molecular pathways are hypothesized to regulate the migration and survival of both immune cells and epithelial tumor cells. The broad goal of our research is to elucidate the mechanistic basis for sialylation-dependent receptor signaling, and to determine whether manipulating sialylation levels can be used as a clinical treatment for pathologies such as autoimmune disorders and metastatic cancer. (2) Biomimetic electrospun matrices for bone repair. The goal of this project is to create bone-like synthetic matrices for bone repair and regeneration. Electrospinning technology is being used to generate composite nanoscale fibrous matrices that incorporate a synthetic polymer (to control tensile strength and degradation kinetics) and two natural bone matrix molecules, collagen I and hydroxyapatite (HA). These composite matrices support robust mesenchymal stem cell (MSC) survival and proliferation in vitro, and also stimulate substantial new bone formation when implanted into bone defects. To further enhance the osteogenic properties of the substrates, the matrices are being functionalized with bioactive factors such as PDGF-BB, a potent chemotactic and proliferative factor for MSCs, and BMP-2, which stimulates MSCs to undergo osteoblastic differentiation. In complementary studies, we are developing novel methods for improving the bonding of bioactive proteins and peptides to HA-containing electrospun substrates. Our broad objective is to synthesize bone-mimicking matrices that, when implanted, stimulate recruitment and osteoblastic differentiation of the patient’s mesenchymal stem cells, leading to accelerated bone regeneration.

Selected Publications  Publication PUBMEDID Phipps, MC, Clem, WC, Grunda, JM, Clines, GA, and Bellis, SL (2012) Increasing the pore sizes of bone-mimetic electrospun scaffolds comprised of polycaprolactone, collagen I and hydroxyapatite to enhance cell infiltration. Biomaterials, 33: 524-34    Liu, Z, Swindall, AF, Kesterson, RA, Schoeb, TR, Bullard, DC, and Bellis, SL (2011) ST6Gal-I regulates macrophage apoptosis via alpha2-6 sialylation of the TNFR1 death receptor, J Biol Chem 286: 39654-62    Swindall, AF and Bellis, SL (2011) Sialylation of the Fas death receptor by ST6Gal-I provides protection against Fas-mediated apoptosis in colon carcinoma cells. J Biol Chem, 286: 22982-22990 (Selected as Editor's Choice manuscript, Science Signaling)    Bellis, SL (2011) Advantages of RGD peptides for directing cell association with biomaterials, Biomaterials, 32: 4205-4210    Phipps, MC, Clem WC, Catledge, SA, Xu, Y, Hennessy, KM, Thomas, V, Jablonsky, MJ, Chowdhury, S, Stanishevsky, AV, Vohra, YK and Bellis, SL (2011) Mesenchymal stem cell responses to bone-mimetic electrospun matrices composed of polycaprolactone, collagen I and nanoparticulate hydroxyapatite. PLoS One, 6: e16813    Zhuo, Y and Bellis, SL (2011) Emerging role of alpha2-6 sialic acid as a negative regulator of galectin binding and function. J Biol Chem, 286: 5935-594

Keywords integrin, death receptors, cell adhesion, apoptosis, signal transduction, glycosylation, extracellular matrix, bone, biomaterials, tissue engineering

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