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Faculty Detail    
Name ALECIA K GROSS
Associate Professor
 
Campus Address SHEL 906 Zip 2182
Phone 205-975-8396
E-mail agross@uab.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Vision Sciences  Vision Sciences Associate Professor
Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Associate Professor
Secondary  Neurobiology  Neurobiology Assistant Professor
Center  Center for Biophysical Sciences/Engineering  Center for Biophysical Sciences/Engineering Associate Professor
Center  General Clinical Research Center  Comprehensive Neuroscience Center Associate Professor
Center  Ctr for Glial Bio in Med  Ctr for Glial Bio in Med Associate Professor
Center  Vision Sciences  Vision Science Research Center Associate Professor

Graduate Biomedical Sciences Affiliations
Biochemistry and Molecular Genetics Program 
Cell, Molecular, & Developmental Biology 
Cellular and Molecular Biology Program 
Genetics and Genomic Sciences 
Medical Scientist Training Program 
Neuroscience 
Neuroscience Graduate Program 

Biographical Sketch 
Alecia Gross earned a B.S. from the University of New Hampshire in Biochemistry and a Ph.D. in Biochemistry from Brandeis University in Waltham, MA in 2002. Prior to joining the UAB faculty in the Department of Vision Sciences in 2006, she was a Postdoctoral Fellow at Baylor College of Medicine in Houston, TX.

Society Memberships
Organization Name Position Held Org Link
Association for Research in Vision and Ophthalmology (ARVO)  NIH/NEI Advocacy Committee Member   
Association for Research in Vision and Ophthalmology (ARVO)  Elected Biochemistry (BI) Program Committee Member  https://www.arvo.org/eweb/StartPage.aspx?Site=arvo2 

Research/Clinical Interest
Title
GPCR trafficking in neurons and rhodopsin-mediated retinal degenerations
Description
The research interests of the Gross Lab are mainly focused on rhodopsin-mediated retinal degenerations and molecular mechanisms of photoreceptor membrane biogenesis; in particular, the molecular interactions necessary for formation of healthy photoreceptor disk membranes. Studies are currently focused on understanding those interactions that are defective when rhodopsin lacks the proper structure at its carboxy-terminus, as is the case in several of most forms of the blinding disease autosomal dominant retinitis pigmentosa. Knock-in mice bearing rhodopsin carboxy-terminal mutations will be used and new ones constructed to aid in the detection of binding partners to the C-terminus of rhodopsin implicated in rhodopsin trafficking.

Selected Publications 
Publication PUBMEDID
McAlear SD, Kraft TW, Gross AK. 2010 Rhodopsin mutations in congenital night blindness. Advances in Experimental Medicine and Biology (10) 664:263-72.  20238025 
Budzynski E, Gross AK, McAlear SD, Peachey NS, Shukla M, He F, Edwards M, Won J, Hicks WL, Wensel TG, Naggert JK, Nishina PM. 2010 Mutations of the opsin gene (Y102H and I307N) lead to light induced degeneration of photoreceptors and constitutive activation of phototransduction in mice. The Journal of Biological Chemistry (10).  20207741 
Zeitz C*, Gross AK*, Leifert D, Kloeckeber-Gruissem B, McAlear SD, Lemke J, Neidhardt J, Berger W. 2008 Identification and functional characterization of a novel rhodopsin mutation associated with autosomal dominant CSNB. Investigative Ophthalmology & Visual Science (08) 49:4105-14. *indicates authors contributed equally.   18487375 
Gross AK, Decker G, Chan F, Sandoval IM, Wilson JH, Wensel TG. Defective development of photoreceptor membranes in a mouse model of recessive retinal degeneration. Vision Research. 2006 Dec;46(27):4510-8.
 
16979686 
Wensel TG, Gross AK, Chan F, Sykoudis K, Wilson J. Rhodopsin-EGFP Knock-ins for Imaging Quantal Gene Alterations. Vision Research. 2005 Dec;45(28):3445-53.  16139321 
Madabushi S, Gross AK, Philippi A, Meng EC, Wensel TG, Lichtarge O. Evolutionary trace of G protein-coupled receptors reveals clusters of residues that determine global and class-specific functions. The Journal of Biological Chemistry. 2004 Feb 27 279(9):8126-32.  14660595 
Gross AK, Rao VR, Oprian DD. Characterization of rhodopsin congenital night blindness mutant T94I. Biochemistry. 2003 Feb 25;42(7):2009-15.  12590588 
Gross AK, Xie G, Oprian DD. Slow binding of retinal to rhodopsin mutants G90D and T94D. Biochemistry. 2003 Feb 25;42(7):2002-8.

 
12590587 
Xie G, Gross AK, Oprian DD. An opsin mutant with increased thermal stability. Biochemistry. 2003 Feb 25;42(7):1995-2001.
 
12590586 
Gross AK, Wang Q, Wensel TG. 2008 Regulation of photoresponses by phosphorylation. Chap. 6 in Barnstable C.J., Tombran-Tink, J., eds., Visual Transduction and Non-Visual Light Perception, Humana Press, Towtowa NJ pp. 125-140.
 
 

Keywords
rhodopsin, autosomal dominant retinitis pigmentosa, congenital stationary night blindness, GPCR trafficking