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Faculty Detail     Name MARY J. MACDOUGALL   Campus Address SDB 702A Zip 0007 Phone 205-996-5122 E-mail macdouga@uab.edu Other websites

Faculty Appointment(s) Appointment Type Department Division Rank Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Professor Secondary  Genetics   Genetic & Translational Med Professor Secondary  Microbiology  Microbiology Professor Secondary  Pathology   Pathology Chair Office Professor Center  Arthritis & Musculoskeletal Diseases Center  Arthritis & Musculoskeletal Diseases Center Center  Center for Metabolic Bone Disease  Center for Metabolic Bone Disease Center  Comprehensive Cancer Center  Comprehensive Cancer Center Center  General Clinical Research Center  Ctr for Clinical & Translational Sci

Graduate Biomedical Sciences Affiliations Medical Scientist Training Program

Biographical Sketch  EDUCATION 1978 B.A., Biochemistry, University of California at San Diego 1984 Ph.D., Craniofacial Biology, University of Southern California, School of Dentistry POSTGRADUATE TRAINING 1985-1986 Postdoctoral Fellow Laboratory for Developmental Biology, Graduate Program in Craniofacial Biology, University of Southern California Honors 2002 International Association for Dental Research, Distinguished Scientist Award, Pulp Biology 2003 American Association for Dental Research Student Research Group Mentor of the Year 2004 President’s Council Chair in Dental Research, Univ. TX Health Science Center at San Antonio 2005 International Association for Dental Research, Distinguished Scientist Award, Mineralized Tissue 2005 James R. Rosen Chair of Dental Research, Univ. of Alabama at Birmingham, Birmingham, AL 2006 Fellow – Dentistry and Oral Health Science, American Association for the Advancement of Science

Society Memberships Organization Name Position Held Org Link American Association for Dental Research  Immediate Past President    American Association for the Advancement of Science  Fellow  www.aaas.org  International Association for Dental Research    www.iadr.org

Research/Clinical Interest Title Description Dr. MacDougall’s research centers on the mechanisms which lead to the formation of teeth in particular the various highly specialized dental cell types of the tooth (odontoblasts ameloblasts and cementoblasts) that produce the unique hard mineralized tissues of the tooth dentin, enamel and cemementum. In order to investigate formation of these dental tissues, we are establishing and characterizing unique immortalized mouse and human cell lines which have the ability to retain their cell type, actively proliferate, and form a characteristic hard matrix (dentin, enamel or cementum) in culture. These cell lines are being used to establish the mechanisms that dictate and control tooth-specific gene expression. These studies will determine why certain genes are only expressed in teeth during human development and how this process is regulated at the DNA level. These studies are correlated with genetic studies on human diseases that effect tooth number, shape and structure such as dentinogenesis imperfecta, radicular dentin dysplasia, amelogenesis imperfecta, tooth agenesis, oligodontia and cleidocranial dysplasia. Mutational studies are determining the precise genes and alterations caused each of these diseases using large informative families. Finally, these studies are culminating in tissue engineering approaches to regenerate tooth structures and ultimately whole teeth through characterization of adult dental stem cells.

Selected Publications  Publication PUBMEDID Gluhak-Heinrich, J, Pavlin, D, Wang, W, MacDougall, M, Harris SE. MEPE Expression in Osteocytes during Orthodontic Tooth Movement. Arch Oral Biol. 2007 Jan 30; [Epub ahead of print].  17270144  Werner, SA, Gluhak-Heinrich, J, Woodruff, K, Wittrant, Y, Cardenas, L, Roudier, M, MacDougall, M. Targeted Expression of csCSF-1 in op/op Mice Ameliorates Tooth Defects. Arch Oral Biol. 2007 May;52(5):432-43. [Epub 2006 Nov 28].  17126805  MacDougall, M., Dong, J., Acevedo, A.C. Molecular Basis of Human Dentin Disease. Am J Hum Genetics 2006 Dec 1;140(23):2536-46.  16955410  Li Y, Decker S, Yuan Z, DenBesten PK, Aragon MA, Jordan-Sciutto K, Abrams WR, Huh J, McDonald C, Chen E, MacDougall M, Gibson CW. Effects of sodium fluoride on the actin cytoskeleton of murine ameloblasts. Archives of Oral Biology. 50:681-688, 2005.  16087229  Boland EJ, MacDougall M, Carnes DL, Dickens SH. In vitro cytotoxicity of a remineralizing resin-based calcium phosphate cement. Dental Materials. 22(4):338-45, 2006. [Epub 2005 Aug 8].  16087229  Paine, M.L., Luo, W., Wang, H.J., Bringas P. Jr., Ngan, A.Y., Miklus, V.G., Zhu, D.H., MacDougall, M. Dentin sialoprotein and dentin phosphoprotein over-expression during amelogenesis. J Biol Chem, 2005. [Epub ahead of print].  16014627  Chen, S., Rani, S., Wu, Y., Unterbrink, A, Gu, T.T., Gluhak-Heinrich, J., Chuang, H.H., Macdougall, M. Differential regulation of dentin sialophosphoprotein expression by Runx2 during odontoblast cytodifferentiation. J Biol Chem, 2005 [Epub ahead of print].  15980071  Papagerakis, P., Ibbarra, J., Inozentseva Clayton, N., DenBesten P., MacDougall, M. Mouse amelogenin exons 8 and 9 sequence analysis and protein distribution. J Dental Research 84(7):613-7, 2005.   15972588  Dong, J., Amore, D., Aldred, M., Gu, T.T., Escamilla, M., MacDougall, M. DLX3 mutation associated with autosomal dominant amelogenesis imperfecta with taurodontism. Am. J. Human Genetics 1;133(2):138-41, 2005.  15666299  MacDougall, M. Discovering the future with a smile. J Dent Res. 84(7):582-3, 2005.

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