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Faculty Detail    
Name ANDRA R FROST
Professor, Department of Pathology
 
Campus Address WTI 320B Zip 3300
Phone 205-934-2746
E-mail afrost@uab.edu
Other websites
     

Education
Undergraduate  Purdue University    1979  none 
Undergraduate  University of Tennessee    1981  B.A. 
Medical School  University of Tennessee Center for the Health Sciences    1983  none 
Medical School  University of Alabama School of Medicine    1985  M.D. 
Residency  George Washington University    1989  Anatomic and Clinical Pathology 
Fellowship  George Washington University    1990  Surgical Pathology and Cytopathology 

Certifications
American Board of Pathology Certification in Anatomic and Clinical Pathology  1990 
American Board of Pathology, Added Qualification in Cytopathology  1994 
American Board of Pathology, Voluntary Recertification (1-1-2014 to 12-30-2024)  2014 


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Pathology   Anatomic Pathology Professor
Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Professor
Center  Biomedical Engineering  Biomatrix Eng Regen Med (BERM) Ctr Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Professor

Graduate Biomedical Sciences Affiliations
Cancer Biology 
Cell, Molecular, & Developmental Biology 
Cellular and Molecular Biology Program 
Integrative Biomedical Sciences 
Medical Scientist Training Program 
Molecular and Cellular Pathology Program 
Pathobiology and Molecular Medicine 

Biographical Sketch 
Dr. Frost received her B.A. in Liberal Arts from the University of Tennessee at Knoxville (1981) after two years in electrical engineering at Purdue University. She obtained her MD degree from the University of Alabama at Birmingham (1985), followed by residency training in Anatomic and Clinical Pathology and a combined Surgical Pathology and Cytopathology Fellowship at the George Washington University (1985-1990). She was a faculty member of the Departments of Pathology at Georgetown University (1990-1991) and George Washington University (1991-1997) before joining the faculty at UAB (1997). Dr. Frost has practiced as a diagnostic surgical pathologist, cytopathologist, and autopsy pathologist. Her research is focused in breast cancer, particularly stromal-epithelial interactions in breast cancer. She was honored with the Leonard H. Robinson Award for Excellence in Resident Education in Anatomic Pathology in 1998 and was nominated for the UAB President’s Award for Excellence in Teaching in 2013.

Society Memberships
Organization Name Position Held Org Link
American Association for Cancer Research (AACR)     
American Society of Cytopathology     
United States and Canadian Academy of Pathology     

Research/Clinical Interest
Title
Fibroblast-Epithelial Cell Interactions and Developmental Pathways in the Development and Progression of Breast Cancer
Description
Dr. Frostís research is focused on understanding the effects of the microenvironment of the breast on breast carcinogenesis and the progression of breast cancer, with the ultimate goal of identifying new targets for prevention of invasive and metastatic disease. To this end, on-going projects utilize in vitro and in vivo model systems to explore the effects of human breast-derived fibroblasts on the progression of epithelial cells of the breast to carcinoma and metastatic disease, with a current emphasis on the involvement of Hedgehog signaling,in particular the GLI1 transcription, in these epithelial-stromal interactions. Other current topics of investigation are the role of primary cilia in epithelial cells and fibroblasts of the breast and breast cancer and the role of the stroma surrounding ductal carcinoma in situ in the progression to invasive cancer. Dr. Frost is also collaborating with Dr. Joel Berry in the Department of Biomedical Engineering to develop a "microvascularized", three dimensional, in vitro model of breast cancer.

Selected Publications 
Publication PUBMEDID
Frost AR, Hurst DR, Shevde LA, Samant RS. The influence of the cancer microenvironment on the process of metastasis. Int J Breast Cancer 2012:756257.   22570792 
Kwon YJ, Hurst DR, Steg AD, Yuan K, Vaidya KS, Welch DR, Frost AR. Gli1 promotes metastasis and enhances migration and invasion via up-regulation of MMP-11 in ER- negative breast cancer. Clinical & Experimental Metastasis 2011;28(5):437-49.   21442356 
Yuan K, Frolova N, Xie Y, Wang D, Cook L, Kwon YJ, Steg AD, Serra R, Frost AR. Primary Cilia Are Decreased in Breast Cancer: Analysis of a Collection of Human Breast Cancer Cell Lines and Tissues. J Histochem Cytochem. 2010 Oct;58(10):857-70.  20530462  
Xu L, Kwon YJ, Frolova N, Steg AD, Yuan K, Johnson MR, Grizzle WE, Desmond RA, Frost AR. Gli1 promotes cell survival and is predictive of a poor outcome in ERalpha-negative breast cancer. Breast Cancer Res Treat. 2010 Aug;123(1):59-712009 Nov 10.   19902354 
Frolova N, Edmonds MD, Bodenstine TM, Seitz R, Johnson MR, Feng R, Welch DR, Frost AR. A Shift from Nuclear to Cytoplasmic BRMS1 Expression Is Associated with Highly Proliferative ER-negative Breast Cancers. Tumour Biol 2009;30(3):148-59.  19609101 
Sadlonova A, Bowe DB, Novak Z, Mukherjee S, Duncan VE, Page GP, Frost AR. Identification of Molecular Distinctions between Normal Breast-Associated Fibroblasts and Breast Cancer-Associated Fibroblasts. Cancer Microenvironment 2009 2 (1):9-21, Epub 2009 March 19.  19308679 
Talley LI, Chhieng DC, Bell WC, Grizzle WE, Frost AR. Immunohistochemical detection of EGFR, p185erbB-2, Bcl-2 and p53 in breast carcinomas in pre-menopausal and post-menopausal women. Biotech Histochem. 2008 Feb;83(1):5-14  18568671 
Steg A, Vickers SM, Eloubeidi M, Wang W, Eltoum IA, Grizzle WE, Saif MW, Lobuglio AF, Frost AR and Johnson MR. Hedgehog pathway expression in heterogeneous pancreatic adenocarcinoma; implications for the molecular analysis of clinically available biopsies. Diagn Mol Pathol. 2007 Dec;16(4):229-37.   18043287 
Hatsell S, Frost AR. Hedgehog Signaling in Mammary Gland Development and Breast Cancer. Journal of Mammary Gland Biology and Neoplasia. J Mammary Gland Biol Neoplasia. 2007 Sep;12(2-3):163-73.  17623270  
Sadlonova A, Gault SR, Bowe DB, Dumas NA, Van Tine BA, Mukherjee S, Frolova N, Page GP, Welch DR, Novak L, Frost AR. Human breast fibroblasts inhibit growth of the MCF10AT xenograft model of proliferative breast disease. Am J Pathol 2007 Mar;170(3):1064-76.  17322389 
Mukherjee S, Frolova N, Sadlonova A, Novak Z, Steg A, Page GP, Welch DR, Lobo-Ruppert SM, Ruppert JM, Johnson MR, Frost AR. Hedgehog signaling and response to cyclopamine differs in epithelial and stromal cells in benign breast and breast cancer.
Cancer Biology & Therapy 2006; 5(6):674-83.
 
16855373 
Steg A, Wang W, Blanquicett C, Grunda JM, Eltoum IA, Wang K, Buchsbaum DJ, Vickers SM, Russo S, Diasio RB, Frost AR, LoBuglio AF, Grizzle WE, Johnson MR. Multiple gene expression analyses in paraffin-embedded tissues by TaqMan low-density array: Application to hedgehog and Wnt pathway analysis in ovarian endometrioid adenocarcinoma. J Mol Diagn. 2006 Feb;8(1):76-83  16436637 
Sadlonova A, Novak Z, Johnson MR, Bowe DB, Gault SR, Page GP, Thottassery JV, Welch DR, Frost AR. Breast fibroblasts modulate epithelial cell proliferation in three-dimensional in vitro co-culture. Breast Cancer Res. 2005;7(1):R46-59. Epub 2004 Nov 08.
 
15642169  
Talley L, Grizzle WE, Waterbor JW, Brown D, Weiss H, Frost AR. Hormone receptors and proliferation in breast carcinomas of equivalent histological grades in pre- and post-menopausal women. Int J Cancer 2002;98:118-127  11857395 

Keywords
breast cancer, tumor-stromal interactions, GLI-mediated transcription, GLI1, primary cilia