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Faculty Detail     Name MARK OLIVER BEVENSEE   Campus Address MCLM 812 Zip 0005 Phone 205-975-9084 E-mail bevensee@uab.edu Other websites http://138.26.61.118/depts/MEB/SOMResearchFaculty/currentfacultydata.asp?ID=mbevensee

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Associate Professor Secondary  Neurobiology  Neurobiology Assistant Professor Center  Civitan International Research Center  Civitan International Research Center Associate Professor Center  General Clinical Research Center  Comprehensive Neuroscience Center Associate Professor Center  Ctr for Glial Bio in Med  Ctr for Glial Bio in Med Associate Professor Center  Medicine  Nephrology Res & Trng Ctr Associate Professor

Graduate Biomedical Sciences Affiliations Cell, Molecular, & Developmental Biology  Integrative Biomedical Sciences  Integrative Genetics Graduate Program  Medical Scientist Training Program  Neuroscience  Neuroscience Graduate Program  Neurosciences  Pathobiology and Molecular Medicine

Biographical Sketch  Dr. Mark Bevensee, Associate Professor, received his Ph.D. in 1996 from the laboratory of Dr. Walter F. Boron in the Department of Cellular and Molecular Physiology at Yale University. His postdoctoral work was also done at Yale under the direction of Dr. Boron. In the Fall of 2000, Dr. Bevensee joined the faculty at UAB.

Society Memberships Organization Name Position Held Org Link American Physiological Society  Member    American Society for Biochemistry and Molecular Biology  Member    American Society for Cell Biology  Member    Society for Neuroscience  Member

Research/Clinical Interest Title Cellular and Molecular Physiology of Acid-base Transporters and pH Regulation Description My laboratory is interested in the cellular and molecular physiology of intracellular pH (pHi) regulation and acid-base transport in tissues such as the brain, heart, and kidney. We are also interested in how acid-base transporters, as well as ion channels such as the epithelial Na+ channel (ENaC) contribute to Na+ hyperabsorption in mouse models of autosomal recessive polycystic kidney disease (ARPKD). Transporters that move acids (e.g., H+) or bases (e.g., bicarbonate or HCO3– ) across the plasma membrane of cells contribute to many cellular processes, including the regulation of pHi, secretion or reabsorption of ions, and modulation of neuronal activity. Some of these transporters include Na-H exchangers, electrogenic and electroneutral Na/HCO3 cotransporters, and Na-dependent and -independent Cl-HCO3 exchangers. In our cellular studies, we use fluorescence approaches with ion-sensitive dyes and electrophysiological techniques (e.g., patch-clamping) to identify and characterize the function and regulation of ion channels and transporters involved in ion movement and acid-base transport across plasma membranes. In our neuroscience research, we are also interested in the effects of pHi changes and transporter activity on neuronal firing. The laboratory is also elucidating the molecular nature of Na/bicarbonate cotransporters (NBCs) and related proteins present in brain, heart, and kidney. The laboratory is characterizing structure-function relationships, ion translocation, and regulation of the cloned proteins expressed in either frog oocytes impaled with microelectrodes, or transfected mammalian cells loaded with ion-sensitive dyes. Electrophysiological recordings from excised membrane patches from oocytes enable us to identify and characterize intracellular regulators of NBC activity. The results from our cellular and molecular studies will enhance our understanding of the physiology of pHi regulation and the biophysics of bicarbonate transport, as well as elucidate the contribution of acid-base transporters and ion channels to polycystic kidney disease.

Selected Publications  Publication PUBMEDID Thornell IA, Wu J, Liu X & Bevensee MO (2012). PIP2 hydrolysis stimulates electrogenic Na/bicarbonate cotransporter NBCe1-B and -C variants expressed in Xenopus laevis oocytes. J. Physiol. 590: 5993-6011.  22966160  Olteanu D, Liu X, Liu W, Roper VC, Sharma N, Yoder BK, Satlin LM, Schwiebert EM & Bevensee MO (2012). Increased Na+/H+ exchanger activity on the apical surface of a cilium-deficient cortical collecting duct principal cell model of polycystic kidney disease. Am. J. Physiol.: Cell. Physiol. 302: C1436-C1451.  22301060  Majumdar D & Bevensee MO (2010). Na-coupled bicarbonate transporters of the Slc4 family in the nervous system: function, localization, and relevance to neurologic function. Neuroscience 171: 951-972.  20884330  Lee S, Lee HJ, Park HJ, Yang HS, Thornell IM, Bevensee MO & Choi I (2010). Na/bicarbonate cotransporter NBCn1 in the kidney medullary thick ascending limb cell line is upregulated under acidic conditions and enhances ammonium transport. Exp. Physiol. 95:926-937.  20591978  Wang W, Wu J, Bernard K, Li G, Wang G, Bevensee MO & Kirk KL (2010). ATP-independent CFTR channel gating and allosteric modulation by phosphorylation. Proc. Natl. Acad. Sci., U.S.A. 107:3888-3893.  20133716  Wu J, McNicholas CM & Bevensee MO (2009). Phosphatidylinositol 4,5-bisphosphate (PIP2) stimulates the electrogenic Na/bicarbonate cotransporter NBCe1-A expressed in Xenopus oocytes. Proc. Natl. Acad. Sci., U.S.A. 106: 14150-14155.  19667194  Majumdar D, Maunsbach AB, Shacka JJ, Williams JB, Berger UV, Schultz KP, Harkins LE, Boron WF, Roth KA & Bevensee MO (2008). Localization of electrogenic Na/bicarbonate cotransporter NBCe1 variants in rat brain. Neuroscience 155:818-832  18582537  Bevensee MO & Boron WF (2008). Effects of hypoxia on intracellular-pH regulation in astrocytes cultured from rat hippocampus. Brain Res 1193C:143-152  18190894  Liu X, Williams JB, Sumpter BR & Bevensee MO (2007). Inhibition of the Na/bicarbonate cotransporter NBCe1-A by diBAC oxonol dyes relative to niflumic acid and a stilbene. J Membr Biol 215:195-204  17578633  Banizs B, Komlosi P, Bevensee MO, Schwiebert EM, Bell PD & Yoder BK (2007). Altered intracellular pH regulation and Na+/HCO3– transporter activity in choroid plexus of the cilia defective Tg737orpk mutant mouse. Am J Physiol: Cell Physiol 292:C1409-C1416  17182727  First Prev   1 2 3 4 of  4  Next Last

Keywords acid-base, bicarbonate, transporter, brain, fluorescence dyes, glia , heart, intracellular pH, microelectrodes, neuron, Xenopus oocyte, neuronal firing, kidney, polycystic kidney disease, epithelial sodium channel

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