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Faculty Detail    
Name LOUIS J DELL'ITALIA
 
Campus Address BMR2 432 Zip 2180
Phone 205-934-0850
E-mail loudell@uab.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Medicine  Med - Cardiovascular Disease Professor
Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Professor
Secondary  Pathology   Molecular & Cellular Pathology Professor
Center  Biomedical Engineering  Biomatrix Eng Regen Med (BERM) Ctr Professor
Center  Center for Biophysical Sciences/Engineering  Center for Biophysical Sciences/Engineering Professor
Center  Medicine  Comprehensive Diabetes Ctr Professor
Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Professor
Center  Cell, Developmntl, & Integrative Biology  Ctr for Exercise Medicine Professor
Center  Cystic Fibrosis Research Center  Cystic Fibrosis Research Center Professor
Center  Medicine  Ctr Cardiovasc Bio Professor

Graduate Biomedical Sciences Affiliations
Integrative Biomedical Sciences 
Medical Scientist Training Program 

Biographical Sketch 
Dr. Louis J. Dell’Italia was born in Newark, NJ. He received his M.D. from Georgetown University School of Medicine in 1978. He subsequently received Internal Medicine training at Georgetown and Cardiology fellowship training at the University of Texas Health Science Center at San Antonio. Before coming to UAB in 1988, Dr. Dell’Italia was an Assistant Professor in the Division of Cardiology at the University of Texas Health Science Center, San Antonio, Texas.

Research/Clinical Interest
Title
Mechanisms of Remodeling of the Heart in Heart Failure
Description
Dr. Dell'Italia's research program focuses on the mechanisms of remodeling of the heart in heart failure defined by three-dimensional magnetic resonance imaging, changes in cardiomyocyte morphology and extracellular matrix, and the regulatory role of the cardiac renin-angiotensin system. Dr. Dell'Italia's current research program studies: 1) the mechanisms of angiotensin II (ANG II) formation in the normal and hypertrophied heart; 2) the effects of blockade of the renin angiotensin system on LV myocardial remodeling in the dog and human using three-dimensional magnetic resonance imaging and tissue tagging; 3) the contribution of tissue angiotensin-converting enzyme (ACE) to ANG II formation and LV myocardial remodeling using transgenic mice with variable copies of the ACE gene; 4) the interaction of the renin angiotensin system and noradrenergic system in hypertrophy and heart failure; and, 5) the effect of 1-4 on intracellular calcium regulation in the hypertrophied cardiomyocyte. With a better understanding of these mechanisms, Dr. Dell'Italia and associates plan to investigate targeted adjunctive therapies in patients having surgical reconstruction of the LV to reduce wall stress and improve function in the failing heart.

Selected Publications 
Publication PUBMEDID
Stewart JA, Wei C-C, Brower GL, Rynders PE, Hankes GH, Dillon AR, Lucchesi P, Janicki JS, Dell’Italia LJ. Cardiac mast cell and chymase mediated matrix metalloproteinase activity and left ventricular remodeling in mitral regurgitation in the dog. In Press, J Mol Cell Cardiol, 2003.  12676546 
Wei C-C, Tian B, Chen Y-F, Perry G, Meng QC, Oparil S, Dell?Italia LJ. Differential angiotensin II generation in plasma and tissue of mice lacking the angiotensin converting enzyme gene. Am J Physiology 282H2254-H2258, 2002.  12003835 
Perry, GJ, Wei CC, Su X, Bishop SP, Hankes GH, Dillon GH, Mukherjee R, Spinale FG Dell?Italia LJ. Afterload reduction and blockade of the tissue renin angiotensin system does not improve left ventricular and cardiomyocyte remodeling in chronic mitral regurgitation. J Am Coll Cardiol 39:1374-1379, 2002.  11955858 
Hunton DL, Lucchesi PA, Pang Y, Dell’Italia LJ, Marchase RB. Capacitative calcium entry contributes to NFAT nuclear translocation and hypertrophy in cardiomyocytes. J Biol Chem 277:14266-14273, 2002.  11827959 
Wei CC, Ferrario CM, Brosnihan KB, Farrell DM, Bradley WE, Jaffa A, Dell’Italia LJ. Angiotensin peptides modulate bradykinin production in the dog heart in-vivo. J Pharm Exp Therapeut 300:324-329, 2002.  11752132 
Calhoun D, Wei CC, Bradley WE, Dell’Italia LJ. Enalaprilat blunts reflexive increases in cardiac interstitial norepinephrine in conscious rats. J Hypertension 19:2025-2029, 2001.  11677368 
Wei S, Rothstein E, Dell’Italia LJ, Fliegel L, Lucchesi P. Activation of multiple map kinases by H202 is associated with Na+/H+ exchanger phosphorylation in adult rat ventricular cardiomyocytes. Am J Physiol 281:C1542-C1550, 2001.  11600417 
Farrell DM, Wei CC, Tallaj J, Ardell JL, Hageman GR, Armour JA, Hageman GR, Bradley WE, Dell’Italia LJ. Angiotensin II modulates catecholamine release into the interstitial fluid of the canine myocardium in-vivo. Am J Physiol (Heart Circ Physiol) 281:H813-H822, 2001.  11454586 
Tallaj J, Wei CC, Hankes GH, Holland M, Rynders P, Dillon AR, Ardell JL, Armour JA, Lucchesi PA, Dell’Italia LJ. ??-adrenergic receptor blockade attenuates angiotensin II-mediated catecholamine release into the cardiac interstitium in mitral regurgitation. In Press, Circulation, 2003.   
Schultz D, Su X, Wei C-C, Bishop SP, Powell P, Hankes GH, Dillon AR, Rynders P, Spinale FG, Walcott G, Ideker R, Dell’Italia LJ. Increased angiotensin II concentrations and decreased angiotensin II receptor density results in compensated pressure overload in the dog heart. Am J Physiology, 51:H749-H756, 2002.