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Faculty Detail     Name KAI JIAO   Campus Address KAUL 768 Zip 0024 Phone 205-996-4198 E-mail kjiao@uab.edu Other websites

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Genetics   Genetics Research Div Associate Professor Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Associate Professor Secondary  Pathology   Pathology Chair Office Assistant Professor Secondary  Pediatrics   Pediatrics Chair Office Assistant Professor Center  Pathology   Cell Adhesion & Matrix Research Center Associate Professor Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Associate Professor Center  Heflin Genetics Center  Heflin Genetics Center Associate Professor Center  Medicine  Ctr Cardiovasc Bio Associate Professor

Graduate Biomedical Sciences Affiliations Cancer Biology  Cell, Molecular, & Developmental Biology  Cellular and Molecular Biology Program  Genetics and Genomic Sciences  Integrative Genetics Graduate Program  Medical Scientist Training Program

Biographical Sketch  M.D., Beijing Medical University (1992) Ph.D., University of Iowa (2000) Postdoctoral Training, Vanderbilt University Medical Center (2005)

Society Memberships Organization Name Position Held Org Link American Heart Association

Research/Clinical Interest Title TGF-beta/Bmp signaling during cardiogenesis Description Reveal the functions of Tgf-beta/Bmp signaling pathway during cardiogenesis using mice as the model system. Congenital heart defects occur in as many as 1% of newborns, and are the leading cause of infant morbidity and mortality. The most common disorders are caused by malformations in septum formation and valvulogenesis (septal-valvulogenesis) during cardiogenesis. Tgf-beta/Bmp signaling pathways play critical roles during many biological processes including septal-valvulogenesis. Through tissue specific inactivation of genes encoding Bmp4 and the type II receptor of Tgf-beta, Dr. Jiao developed two unique mouse models mimicking two forms of human congenital heart disease during his postdoctoral training period. The current focus of the lab is to reveal the functions of Tgf-beta/Bmp signaling during cardiogenesis utilizing the powerful tools of mouse molecular genetics complemented with cellular and biochemical approaches.

Selected Publications  Publication PUBMEDID Debenedittis P, and Jiao K (2011) Alternative splicing of T-box transcription factor genes. Biochem. Biophys. Res. Commun. 412:513-517 (Epub, Aug. 11th, 2011)   21856288  Espinoza-Lewis RA, Liu H, Sun C, Chen C, Jiao K, Chen YP (2011) Ectopic expression of Nkx2.5 suppresses the formation of the sinoatrial node in mice. Dev. Biol. 356:359-69, (Epub. May 26th, 2011)   21640717  Debenedittis P, Harmelink C, Chen Y, Wang Q, Jiao K (2011) Characterization of the novel interaction between muskelin and TBX20, a critical cardiogenic transcription factor. Biochem. Biophys. Res. Commun. 409:338-43 (Epub, May 8th, 2011)   21586270  Nie X, Wang Q and Jiao K (2011) Dicer activity in neural crest cells is essential for craniofacial organogenesis and pharyngeal arch artery morphogenesis. Mechanisms of Development 128:200-7 (Epub, Jan. 21st, 2011)   21256960  Nie X, Brown C, Wang Q and Jiao K (2011) Inactivation of Bmp4 from the Tbx1 expression domain causes abnormal pharyngeal arch artery and cardiac outflow tract remodeling. Cells Tissues Organs 193:393-403 ( Epub, Dec. 1st, 2010)   21123999  Song L., Zhao M, Wang Q and Jiao K (2011) Cell autonomous requirement of endocardial Smad4 during atrioventricular cushion development in mouse embryos. Dev. Dyn. 240: 211-220 (Epub, Nov. 18th, 2010)   21089072  Wang B, Sinha T, Jiao K, Serra R, and Wang J (2011) Disruption of PCP signaling causes limb morphogenesis and skeletal defects and may underlie Robinow syndrome and brachydactyly type B. Hum. Mol. Genet. 20:271-285 (Epub, Nov. 8th, 2010)   20962035  Lu R, Chen Y, Peng N, Jiao K, Limbird LE, Wyss JM and Wang Q (2009) Enhanced hypotensive, bradycardic, and hypnotic responses to alpha2-adrenergic agonists in spinophilin-null mice are accompanied by increased G protein coupling to the alpha2A-adrenergic receptor. Mol. Pharm. 78:279-86   20430865  Lu R, Li Y, Zhang Y, Chen Y, Shields AD, Winder DG, Angelotti T, Jiao K, Limbird LE, Zhou Y, Wang Q. (2009) Epitope-tagged receptor knock-in mice reveal that differential desensitization of {alpha}2-Adrenergic responses Is because of ligand-selective Internalization. J Biol Chem. 284:13233-43   19276088  Xu J, Chen Y, Lu R, Cottingham C, Jiao K and Wang Q (2008) Protein Kinase A Phosphorylation of Spinophilin Modulates Its Interaction with the {alpha}2A-Adrenergic Receptor (AR) and Alters Temporal Properties of {alpha}2AAR Internalization. J Biol Chem. 283:14516-23  18367453  First Prev   1 2 3 of  3  Next Last

Keywords Tgfbeta, BMP, heart development, mouse genetics, development

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