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Faculty Detail    
Name KEVIN F DYBVIG
 
Campus Address KAUL 720A Zip 0024
Phone 205-934-9327
E-mail dybvig@uab.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Genetics   Genetics Research Div Professor
Secondary  Microbiology  Microbiology Associate Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Professor

Graduate Biomedical Sciences Affiliations
Cellular and Molecular Biology Program 
Genetics and Genomic Sciences 
Immunology 
Integrative Biomedical Sciences 
Integrative Genetics Graduate Program 
Medical Scientist Training Program 
Microbiology 
Waiting to be Seated 

Biographical Sketch 
Kevin F. Dybvig (b. 1954), Professor of Genetics and Associate Professor of Microbiology, completed his undergraduate studies in physics at Kenyon College (B.A., 1976) and graduate studies in biophysics at the University of Rochester (M.S., 1978; Ph.D., 1981), studying the basic biology and genetics of mycoplasmas. He attended Washington University (1981-1983) for postdoctoral studies concerning the regulation of avian heat shock proteins and joined UAB in 1984 for additional postdoctoral studies in the area of mycoplasmal pathogenic mechanisms. He joined the UAB faculty in 1987.

Society Memberships
Organization Name Position Held Org Link
International Organization for Mycoplasmology  Past Chair  http://mycoplasmas.vm.iastate.edu/ 

Research/Clinical Interest
Title
Pathogenic mechanisms of mycoplasmas
Description
Dr. Dybvig’s research is focused on the basic biology and pathogenic mechanisms of mycoplasmas. The mycoplamas are a group of bacteria that cause a variety of chronic diseases including pneumonia and arthritis in humans and animals. The experimental infection of murine animals with mycoplasmas serves as models for understanding host-pathogen interactions in humans. A major effort is directed towards understanding the development of pneumonia caused by infection with the respiratory and genital pathogen Mycoplasma pulmonis. A second major effort is directed toward understanding the development of arthritis caused by infection of Mycoplasma arthritidis. Mycoplasmal factors associated with disease severity, host factors associated with protection, and host factors associated with high risk are under study. Current efforts are focused intensely on polysaccharides with roles in protection from host immunity and in biofilm formation and on protein glycosylation in mycoplasmas.

Selected Publications 
Publication PUBMEDID
Dybvig, K., Lao, P., Jordan, D. S., and Simmons, W. L. Fewer essential genes in mycoplasmas than previous studies suggest. FEMS Microbiol. Lett. 311:51-55, 2010.  2974803 
Daubenspeck, J. M., Bolland, J. R., Luo, W., Simmons, W. L., and Dybvig, K. Identification of exopolysaccharide-deficient mutants of Mycoplasma pulmonis. Mol. Microbiol. 72:1235-1245, 2009.  2752295 
Simmons, W. L. and Dybvig, K. Mycoplasma biofilms ex vivo and in vivo. FEMS Microbiol. Lett. 295:77-81, 2009.  2703428 
Luo, W., Tu, A.-H. T., Cao, Z., Yu, H., and Dybvig, K. Identification of an isoschizomer of the HhaI DNA methyltransferase in Mycoplasma arthritidis. FEMS Microbiol. Lett. 290:195-198, 2009.  2668981 
Jordan, D. S., Daubenspeck, J. M., and Dybvig, K.. Rhamnose biosynthesis in mycoplasmas requires precursor glycans larger than monosaccharide. Mol. Microbiol. 89:918-928, 2013.  23826905 
Simmons, W. L., Daubenspeck, J. M., Osborne, J. D., Balish, M. F., Waites, K. B., and Dybvig, K. Type 1 and type 2 strains of Mycoplasma pneumoniae form different biofilms. Microbiology 159: 737-747, 2013.  23412845 
Shaw, B. M., Daubenspeck, J. M., Simmons, W. L., and Dybvig, K. EPS-I polysaccharide protects Mycoplasma pulmonis from phagocytosis. FEMS Microbiol. Lett. 338:155-160, 2013.   23190331 
Bolland, J. R., Simmons, W. L., Daubenspeck, J. M., and Dybvig, K. Mycoplasma polysaccharide protects against complement. Microbiology 158:1867-1873, 2012.  22504437 
Bolland, J. R. and Dybvig, K. Mycoplasma pulmonis Vsa proteins and polysaccharide modulate adherence to pulmonary epithelial cells. FEMS Microbiol. Lett. 331:25-30, 2012.  22428866 
Shaw, B. M., Simmons, W. L., and Dybvig, K. The Vsa shield of Mycoplasma pulmonis is antiphagocytic. Infect. Immun. 80:704-709, 2012.  22083715 
Luo, W., Yu, H., Cao, Z, Schoeb, T. R., Marron, M., and Dybvig, K. Association of M. arthritidis mitogen with lethal toxicity but not with arthritis in mice. Infect. Immun. 75: 4989-4998, 2008.   18779340 
Dybvig, K., Zuhua, C., Lao, P., Jordan, D. S., French, C. T., Tu, A.-H. T., and Loraine, A. E. Genome of Mycoplasma arthritidis. Infect. Immun. 76: 4000-4008, 2008.  18573899 
French, C. T. French, Lao, P., Loraine, A. E., Matthews, B. T., Yu, H., and Dybvig, K. Large-scale transposon mutagenesis of Mycoplasma pulmonis. Mol. Microbiol. 69:67-76, 2008.  18452587