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Faculty Detail     Name JIANHUA ZHANG   Campus Address BMR2 534 Zip 2180 Phone 205-996-5153 E-mail zhanja@uab.edu Other websites

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Pathology   Molecular & Cellular Pathology Associate Professor Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Associate Professor Secondary  Neurobiology  Neurobiology Assistant Professor Center  Center for Aging  Center for Aging Associate Professor Center  Civitan International Research Center  Civitan International Research Center Associate Professor Center  General Clinical Research Center  Comprehensive Neuroscience Center Associate Professor Center  Neurology   Ctr Neurodegeneration & Exp Ther (CNET) Associate Professor

Graduate Biomedical Sciences Affiliations Cell, Molecular, & Developmental Biology  Cellular and Molecular Biology Program  Integrative Genetics Graduate Program  Medical Scientist Training Program  Molecular and Cellular Pathology Program  Neuroscience  Neuroscience Graduate Program  Pathobiology and Molecular Medicine

Biographical Sketch  Dr. Zhang graduated from University of Science and Technology of China. She received her PhD from University of Texas Southwestern Medical Center at Dallas. She then worked as a postdoctoral associate in the Whitehead Institute for Biomedical Research, and as a Research Assistant Professor in University of Cincinnati College of Medicine. She joined UAB in 2005.

Society Memberships Organization Name Position Held Org Link American Physiology Society  member    Association for Neuron and Disease (AND)  member    Birmingham Chinese Professor Association (BCPA)  president    Chinese Biologic Investigator Society (Ray Wu society)  member    Society for Free Radical Biology and Medicine (SFRBM)  council member    Society for Neuroscience (SFN)  member    Society of Chinese Bioscientists in America (SCBA)  member

Research/Clinical Interest Title Mechanisms and regulation of autophagy-lysosomal pathway in health and diseases Description Our long-term research interests are to understand the cellular and molecular mechanisms responsible for autophagy, cellular bioenergetics, oxidative stress and cell death, in the context of human diseases. We use transgenic and conditional knockout mouse models, cell differentiation models to dissect mechanisms and pathways. Autophagy regulation is important for healthy aging, combating neurodegenerative, cardiovascular, liver and metabolic diseases. My laboratory currently constitutes 2 PhD earning graduate students, and 2 research associates. We are currently funded by VA and NINDS.

Positions Available Date Posted Position Title 3/29/2013  MSTP and PhD graduate students  1 highly motivated, hardworking and talented graduate students who are interested in molecular cellular mechanisms of autophagy/mitophagy using mouse models, primary and differentiated cell models to study how autophagy is regulated by mitochondrial dysfunction, glucose metabolism, oxidative stress and protein aggregation, and how autophagic activities play a role in response to these cellular stress.

Selected Publications  Publication PUBMEDID Biochem J. 2013 Jun 17. [Epub ahead of print] Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblasts. Liang Q, Benavides GA, Vasilopoulos A, Gius D, Darley-Usmar V, Zhang J.  23767918  Dodson M, Darley-Usmar V, Zhang J. Cellular Metabolic and Autophagic Pathways: Traffic Control by Redox Signaling. Free Radic Biol Med. 2013 May 20. pii: S0891-5849(13)00224-4.   23702245  Le Grand JN, Bon K, Fraichard A, Zhang J, Jouvenot M, Risold P-Y, Boyer-Guittaut M, Delage-Mourroux R (2012) Specific distribution of the autophagic protein GABARAPL1/GEC1 in the developing and adult mouse brain and identification of neuronal populations expressing GABARAPL1/GEC1. PlosOne 2013 May 15;8(5):e63133  23690988  Parekh VV, Wu L, Boyd KL, Williams, JA, Gaddy JA, Olivares-Villagomez D, Cover TL, Zong WZ, Zhang J, Van Kaer L (2013) Impaired autophagy, defective T cell homeostasis and a wasting syndrome in mice with a T cell-specific deletion of Vps34. Journal of Immunity 2013 May 15;190(10):5086-101.  23596309  Errami Y, Brim H Oumouna-Benachour K, Oumouna M, Naura AS, Kim H, Ju J, Kim JG, Ashktorab H, Fallon K, Xu M, Zhang J, Del Valle L, Boulares HA (2013) ICAD deficiency in human colon cancer and predisposition to colon tumorigenesis: linkage to apoptosis resistance and genomic instability". PlosOne 2013;8(2):e57871.  23451280  Crabtree D, Boyer-Guittaut M, Ouyang X, Fineberg N, Zhang J (2013) Dopamine and its metabolites in cathepsin D heterozygous mice before and after MPTP administration. Neuroscience Letters Mar 22;538:3-8  23391753  Mitchell T, Bailey SM, Ballinger SW, Zhang J, Darley-Usmar VM (2013) Convergent mechanisms for mitochondrial dysfunction in metabolic disease; insights from mitochondrial therapeutics. Biochemical Society Transactions 41:127-133  23356271  Errami Y, Naura AS, Kim H, Ju J, Suzuki Y, El-Bahrawy, AH, Ghonim MA, Hemeida RA, Mansy MS, Zhang J, Xu M, Boulares AH (2013) Apoptotic DNA fragmentation may be a cooperative activity between caspase-activated DNase and the PARP-regulated DNas1L3, an ER-localized endonuclease that translocates to the nucleus during apoptosis. J Biol Chem. 2013 Feb 1;288(5):3460-8.  23229555  Hill B, Benavides G, Lancaster J, Ballinger S, Dell’Italia L, Zhang J, Darley-Usmar VM (2012) Integration of cellular bioenergetics with mitochondrial quality control and autophagy. Biological Chemistry 393:1485-1512  23092819  Giordano S, Jisun Lee, Darley-Usmar VM, Zhang J (2012) Distinct effects of rotenone, 1-methyl-4-phenylpyridinium and 6-hydroxydopamine on cellular bioenergetics and cell death. PlosOne 7(9):e44610. PMCID:PMC3435291  22970265  First Prev   1 2 3 4 5 6 of  6  Next Last

Keywords Autophagy, Parkinson's Disease, Huntington's disease, signal transduction, mouse genetic engineering, cell and molecular biology, lysosomes, mitochondria, oxidative stress

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