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Faculty Detail     Name JI-BIN PENG   Campus Address ZRB 634 Zip 0007 Phone 205-975-6130 E-mail jpeng@uab.edu Other websites

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Medicine  Med - Nephrology Associate Professor Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Associate Professor Center  Center for Metabolic Bone Disease  Center for Metabolic Bone Disease Associate Professor Center  Medicine  Comprehensive Diabetes Ctr Associate Professor Center  Medicine  Nephrology Res & Trng Ctr Associate Professor

Graduate Biomedical Sciences Affiliations Cell, Molecular, & Developmental Biology  Genetics and Genomic Sciences  Pathobiology and Molecular Medicine

Biographical Sketch  Dr. Peng received his Ph.D. degree from Shanghai Institute of Cell Biology of the Chinese Academy of Sciences. Dr. Peng had his postdoctoral training at Brigham & Women’s Hospital and Harvard Medical School during 1997 to 2000 (Mentored by Drs. Matthias Hediger and Edward Brown). He became an Instructor in Medicine at Harvard Medical School in 2000. Dr. Peng Joined the University of Alabama at Birmingham (UAB) as an Assistant Professor in 2003. He is currently an Associate Professor of Medicine at UAB.

Society Memberships Organization Name Position Held Org Link American Heart Association  Member    American Physiological Society  Member    American Society for Biochemistry and Molecular Biology  Member    American Society of Nephrology  Member

Research/Clinical Interest Title Calcium transport proteins and their roles in health and disease Description Research in Dr. Peng’s laboratory is centered on the mechanism and regulation of calcium transport pathways. Calcium is a major inorganic component of the skeleton and serves as a key extracellular and intracellular messenger. Intestinal absorption and renal reabsorption of calcium play crucial roles in maintaining calcium balance of the body. Defects in calcium transport may result in disorders such as kidney stone disease and osteoporosis. Towards a better understanding of calcium transport and its relation to hypercalciuria and hypertension, Dr. Peng’s laboratory is investigating molecular mechanisms of calcium absorption and reabsorption. Two calcium channels, TRPV5 and TRPV6, are the focus of current investigation. Dr. Peng’s group is also working on the mechanisms of WNK4 kinase activation by calcium ions. WNK4 is a protein kinase linked to pseudohypoaldosteronism type II, a genetic form of hypertension. It is expected that those studies will lead to novel therapeutic strategies for hypercalciuria and hypertension.

Selected Publications  Publication PUBMEDID Zhang Y, Zhang Y, Bone RN, Cui W, Peng JB, Gene P. Siegal GP, Wang H, Wu H. Regeneration of Pancreatic non-β Endocrine Cells in Adult Mice Following a Single Diabetes-Inducing Dose of Streptozotocin. PLoS ONE, 7(5):e36675.2012.  22586489  Wu G, Zhang W, Na T, Jing H, Wu H, Peng JB. Suppression of intestinal calcium entry channel TRPV6 by OCRL, a lipid phosphatase associated with Lowe syndrome and Dent disease. Am J Physiol Cell Physiol. 302:C1479-91, 2012.  22378746  Na T, Wu G, Peng JB. Disease-causing mutations in the acidic motif of WNK4 impair the sensitivity of WNK4 kinase to calcium ions. Biochem Biophys Res Commun. 419: 293-298. 2012.   22342722  Peng JB. TRPV5 and TRPV6 in transcellular Ca2+ transport: regulation, gene duplication, and polymorphisms in African populations. Adv Exp Med Biol. 704:239-75, 2011.  21290300  Jing H, Na T, Zhang W, Wu G, Liu C, Peng JB. Concerted actions of NHERF2 and WNK4 in regulating TRPV5. Biochem Biophys Res Commun. 404:979-84, 2011.  21187068  Zhang W, Na T, Wu, G, Jing H, Peng JB. Downregulation of intestinal apical calcium entry channel TRPV6 by ubiquitin E3 ligase Nedd4-2. J Biol Chem. 285:36586-96.2010.  20843805   Lieben L, Benn BS, Ajibade D, Stockmans I, Moermans K, Hediger MA, Peng JB, Christakos S, Bouillon R, Carmeliet G. Trpv6 mediates intestinal calcium absorption during calcium restriction and contributes to bone homeostasis. Bone. 47(2):301-8. 2010.   20399919  Na T, Zhang W, Jiang Y, Liang YY, Ma HP, Warnock DG, Peng JB. The A563T variation of the renal epithelial channel TRPV5 among African Americans enhances calcium influx. Am J Physiol Renal Physiol. 2009 Mar 4. [Epub ahead of print]  19261737  Ji HL, Song W, Gao Z, Su XF, Nie HG, Jiang Y, Peng JB, He YX, Liao Y, Zhou YJ, Tousson A, Matalon S. SARS-CoV proteins decrease levels and activity of human ENaC via activation of distinct PKC isoforms. Am J Physiol Lung Cell Mol Physiol. 296:L372-83. 2009.   19112100  Nie HG, Tucker T, Su XF, Na T, Peng JB, Smith PR, Idell S, Ji HL. Expression and Regulation of Epithelial Na+ Channels by Nucleotides in Pleural Mesothelial Cells. Am J Respir Cell Mol Biol. 2008 Oct 16. [Epub ahead of print]  18927349  First Prev   1 2 3 4 5 of  5  Next Last

Keywords Calcium transport, absorption, reabsorption, hyercalciuria, hypertension, TRPV6, TRPV5, WNK4

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