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Faculty Detail     Name ANUPAM AGARWAL   Campus Address FOT 1203 Zip 0006 Phone 205-934-1111 E-mail agarwal@uab.edu Other websites

Certifications ABIM Internal medicine  2007  ABIM Interrnal Medicine - Nephrology  2008

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Medicine  Med - Nephrology Professor Secondary  Biochemistry & Molecular Genetics  Biochemistry & Molecular Genetics Associate Professor Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Professor Secondary  Pathology   Molecular & Cellular Pathology Professor Center  Arthritis & Musculoskeletal Diseases Center  Arthritis & Musculoskeletal Diseases Center Professor Center  Pathology   Cell Adhesion & Matrix Research Center Professor Center  Center for Aging  Center for Aging Professor Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor Center  Medicine  Comprehensive Diabetes Ctr Professor Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Professor Center  Medicine  Ctr Cardiovasc Bio Professor Center  Medicine  Gene Therapy Center Professor Center  Medicine  Nephrology Res & Trng Ctr Professor

Graduate Biomedical Sciences Affiliations Biochemistry and Molecular Genetics Program  Biochemistry and Structural Biology  Cell, Molecular, & Developmental Biology  Cellular and Molecular Biology Program  Hughes Med-Grad Fellowship Program  Medical Scientist Training Program  Pathobiology and Molecular Medicine

Biographical Sketch  Dr. Agarwal graduated with honors from Kasturba Medical College in India. He completed his residency at the Postgraduate Institute of Medical Education and Research in India, where he also completed a nephrology fellowship. Dr. Agarwal was a nephrology fellow at the University of Minnesota Hospital and Clinic in Minneapolis. He then joined the Division of Nephrology, Hypertension, and Transplantation at the University of Florida in Gainesville as an assistant professor and was promoted to tenured associate professor. He also served as the interim chief for research, prior to joining UAB. He was promoted to the rank of Professor at UAB in October 2005 and was named the Thomas E. Andreoli Professor of Nephrology in September 2006. He was appointed Division Director for Nephrology at UAB in January 2008 and Vice Chair for Research for the UAB Department of Medicine in October 2009. He was appointed to the Marie S. Ingalls Endowed Chair in Nephrology Leadership in April 2011 and served as Interim Chairman for the UAB Department of Medicine (August 1, 2011-August 31, 2012).

Society Memberships Organization Name Position Held Org Link American Clinical and Climatological Association      American Society for Clinical Investigation      American Society of NephrologyNational Kidney FoundationInternational Society of NephrologySociety for Free Radical BiologyAmerican Federation for Medical ResearchSouthern Society for Clinical Investigation

Research/Clinical Interest Title Regulation of heme oxygenase gene expression in kidney and vascular injury Description Dr. Agarwal's principal interests in clinical nephrology include acute renal failure, specifically in the intensive care unit setting, toxic nephropathies, fluid and electrolyte disorders, glomerular disorders, progression of renal disease, and diabetic nephropathy. His long term goals are to pursue a career in academic nephrology with the primary focus being on basic research, teaching and patient care. His goal is to apply knowledge gained from bench research to the bedside, enabling research to be a significant contributor to advancement in clinical medicine. Dr. Agarwal’s research efforts include three main areas. (i) His laboratory is studying the molecular regulation of the human heme oxygenase-1 (HO-1) gene in renal injury and in atherosclerosis. Induction of this gene occurs as an adaptive and beneficial response to injury and is protective in several clinically important conditions such as acute renal failure, transplant rejection, angiogenesis and atherosclerosis. Studies are focused on identifying regulatory regions in the human HO-1 gene that mediate induction in response to stimuli such as heme, cytokines, nitric oxide, modified lipids and growth factors (eg. transforming growth factor-beta). The studies involve molecular biology techniques to study DNA-protein interactions using chromatin structure analysis, in vivo footprinting, site-directed mutagenesis and gel shift assays. His laboratory is also studying the molecular and biological effects of nitrated lipids on HO-1 gene expression in endothelial cells and in the vasculature. (ii) The functional significance of HO-1 gene expression is also being evaluated using both in vitro and in vivo systems in transgenic animal models of acute renal injury, transplantation and atherosclerosis. (iii) His laboratory is actively pursuing gene delivery approaches in the kidney and the vasculature in animal models of transplantation using recombinant adeno-associated viral vectors. Alternate serotypes and capsid mutants of adeno-associated viral vectors are being developed to maximize gene transfer to the otherwise resistant vascular compartment in the kidney.

Selected Publications  Publication PUBMEDID Regev D, Surolia R, Karki S, Zolak J, Montes-Worboys A, Oliva O, Guroji P, Saini V, Steyn AJC, Agarwal A, Antony VB. Heme oxygenase-1 promotes granuloma development and protects against dissemination of mycobacteria. Laboratory Investigation, 2012;92:1541-1552  22964851   Schoeb TR, Jarmi T, Hicks JM, Henke S, Zarjou A, Hitoshi S, Kramer P, Novak J, Agarwal A, Bullard DC. Endothelial nitric oxide synthase inhibits the development of autoimmune-mediated vasculitis in mice. Arthritis and Rheumatism. 2012;64:4114-4124.   22933338  Zarjou A, Guo L, Sanders PW, Mannon RB, Agarwal A, George JF. A reproducible mouse model of chronic allograft nephropathy with vasculopathy. Kidney International 2012;82:1231-1235.   22874842  Kim J, Zarjou A, Traylor AM, Hull TD, Jaimes EA, George JF, Mikhail FM, Agarwal A. In vivo regulation of the heme oxygenase-1 gene in humanized transgenic mice. Kidney International. 2012;82:278-91.   22495295  Zarjou A, Yang S, Abraham E, Agarwal A, Liu G. Identification of a microRNA signature in renal fibrosis: role of miR-21. Am J Physiol Renal Physiol. 2011 Oct;301(4):F793-801.  21775484  Zavaczki E, Jeney V, Agarwal A, Zarjou A, Oros M, Katkó M, Varga Z, Balla G, Balla J. Hydrogen sulfide inhibits the calcification and osteoblastic differentiation of vascular smooth muscle cells. Kidney Int. 2011 Oct;80(7):731-9.  21716261  Lu A, Miao M, Schoeb TR, Agarwal A, Murphy-Ullrich JE. Blockade of TSP1-dependent TGF-β activity reduces renal injury and proteinuria in a murine model of diabetic nephropathy. Am J Pathol. 2011 Jun;178(6):2573-86.  21641382  Zarjou A, Agarwal A. Sepsis and acute kidney injury. J Am Soc Nephrol. 2011 Jun;22(6):999-1006.  21566052  Wu QQ, Wang Y, Senitko M, Meyer C, Wigley WC, Ferguson DA, Grossman E, Chen J, Zhou XJ, Hartono J, Winterberg P, Chen B, Agarwal A, Lu CY. Bardoxolone Methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes - Nrf2, PPAR{gamma}, and HO-1. Am J Physiol Renal Physiol. 2011 Feb 2. [Epub ahead of print]  21289052  Zarjou A, Kim J, Traylor AM, Sanders PW, Balla J, Agarwal A, Curtis LM. Paracrine effects of mesenchymal stem cells in cisplatin-induced renal injury require heme oxygenase-1. Am J Physiol Renal Physiol. 2011 Jan;300(1):F254-62.  21048024  First Prev   1 2 3 4 5 6 of  6  Next Last

Keywords heme oxygenase, acute renal failure, atherosclerosis, transcriptional gene regulation

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