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Faculty Detail     Name JOHN JOSEPH HABLITZ   Campus Address SHEL 1014 Zip 2182 Phone 205-934-0742 E-mail jhablitz@uab.edu Other websites

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Neurobiology  Neurobiology Professor Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Professor Center  Civitan International Research Center  Civitan International Research Center Professor Center  Ctr for Glial Bio in Med  Ctr for Glial Bio in Med Professor

Graduate Biomedical Sciences Affiliations Cell, Molecular, & Developmental Biology  Cellular and Molecular Biology Program  Integrative Biomedical Sciences  Medical Scientist Training Program  Neuroscience  Neuroscience Graduate Program  Neurosciences  Pathobiology and Molecular Medicine

Biographical Sketch  John Hablitz received his Ph.D. in Psychology from the University of Houston in 1972. Following an Associate Professor position at Baylor College of Medicine, he joined UAB in 1989. He is presently Professor of Neurobiology.

Society Memberships Organization Name Position Held Org Link American Epilepsy Society  Member  www.aesnet.org  Society for Neuroscience  Member  www.sfn.org

Research/Clinical Interest Title Cellular Mechanisms of Neurotransmission Description Dr. Hablitz is using studies on synaptic transmission to further understand basic biophysical properties of mammalian central neurons, as well as to explore the pathophysiology of experimental epilepsy. Electrophysiological techniques, including whole-cell voltage-clamp recordings from visually identified neurons, are used in brain slice preparations. The goal of these studies is to determine the types of synaptic interactions present among pyramidal cells and interneurons in neocortex and how these patterns change during development. Additional studies involve the use of optical imaging techniques. These studies examine the role of presynaptic receptors in regulating glutamate and GABA release from individual synaptic boutons in normal neocortex and an animal model of cortical dysplasia.

Selected Publications  Publication PUBMEDID Mathew, S.S. and Hablitz, J.J. Presynaptic NMDA receptors mediate IPSC potentiation at GABAergic synapses in developing rat neocortex. PlosOne 2011, 6:e17311.   21365001  Calfa, G., Hablitz, J.J. and Pozzo-Miller, L. Network hyperexcitability in hippocampal slices from mecp2 mutant mice revealed by voltage-sensitive dye imaging. J Neurophysiol. 2011, 105:1768-84.   21307327  Albertson, A., Yang, J. and Hablitz, J.J. Decreased hyperpolarization-activated current (Ih) in layer 5 pyramidal neurons enhances excitability in focal cortical dysplasia. J Neurophysiol. 2011 Jul 27.   21307327  Mathew, S.S., Pozzo-Miller, L. and Hablitz, J.J. Kainate modulates presynaptic GABA release from two vesicle pools. J. Neurosci. 2008, 28:725-731  18199771  Campbell, S.L., Mathew, S.S., Hablitz, J.J. Pre- and postsynaptic effects of kainate on layer II/III pyramidal cells in rat neocortex. Neuropharmacology, 2007, 53: 37-47.  17543353   Bandyopadhyay, S., Sutor, B. and Hablitz, J.J. Endogenous acetylcholine enhances synchronized interneuron activity in rat neocortex. J Neurophysiol, 2006; 95: 1908-1916  16338999  Wu, JP and Hablitz, JJ.Cooperative activation of D1 and D2 dopamine receptors enhances a hyperpolarization-activated inward current in layer I interneurons. J Neurosci. 2005, 25:6322-8  16000622   Keros, S and Hablitz, JJ. Subtype-specific GABA transporter antagonists synergistically modulate phasic and tonic GABAA conductances in rat neocortex. J Neurophysiol. 2005, 94:2073-85.  15987761  Campbell, SL and Hablitz, JJ. Glutamate transporters regulate excitability in local networks in rat neocortex. Neuroscience. 2004;127(3):625-35.  15283962   Gonzalez-Islas C and Hablitz, JJ. Dopamine enhances EPSCs in layer II/III pyramidal neurons in rat prefrontal cortex. J. Neurosci. 2003, 23: 867-875.  12574415  First Prev   1 2 of  2  Next Last

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