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Faculty Detail    
Name JEFFREY A ENGLER
 
Campus Address LHL G03 Zip 0013
Phone 205-934-4734
E-mail engler@uab.edu
Other websites
     


Faculty Appointment(s)
Appointment Type Department Division Rank
Primary  Biochemistry & Molecular Genetics  Biochemistry & Molecular Genetics Professor
Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Professor
Center  Arthritis & Musculoskeletal Diseases Center  Arthritis & Musculoskeletal Diseases Center Professor
Center  Pathology   Cell Adhesion & Matrix Research Center Professor
Center  Center for AIDS Research  Center for AIDS Research Professor
Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor
Center  Ctr for Glial Bio in Med  Ctr for Glial Bio in Med Professor
Center  Cystic Fibrosis Research Center  Cystic Fibrosis Research Center Professor

Graduate Biomedical Sciences Affiliations
Biochemistry and Molecular Genetics Program 
Medical Scientist Training Program 

Biographical Sketch 
Jeffrey A. Engler completed undergraduate studies in chemistry at the University of California, Santa Barbara (B.S. 1971) and graduate studies in biochemistry at the University of Wisconsin (Ph.D. in 1977). His postdoctoral studies at Cold Spring Harbor Laboratory in Long Island, New York led to a staff appointment there in 1980. Twice during his tenure there, the Leukemia Society of America awarded support for his work on adenoviruses. Dr. Engler joined the faculty at UAB in 1982, and he is currently Professor of Biochemistry and Molecular Genetics. He was an Editor for the journal GENE from 1986 to 2008. In May, 2006, he was selected as Associate Dean for Academic Affairs in the UAB Graduate School.

Society Memberships
Organization Name Position Held Org Link
American Association for Biochemistry and Molecular Biology     
American Association for the Advancement of Science     
American Society for Cell Biology     
American Society for Gene Therapy     
American Society for Microbiology     
American Society for Virology     

Research/Clinical Interest
Title
Supporting Graduate Student Education and Development
Description
Since being appointed as Associate Dean for Academic Affairs in the UAB Graduate School, I have ended my laboratory research activities. Currently, I am interested in embedding research ethics and scholarly integrity education into the graduate curriculum. I teach the Scientific Integrity course for biomedical graduate students and postdocs each Fall and Spring semester. I was the Director of the Ronald E. McNair Postbaccalaureate Achievement Program (funded by the US Department of Education) from 2006 through 2012 and am currently the Director of the Postbaccalaureate Research and Education Program (PREP) funded by the National Institute of General Medical Sciences (NIGMS). I also oversee the Professional Development and "English as a Second Language" programs within the Graduate School.

Selected Publications 
Publication PUBMEDID
Borhani, D., Rogers, D., Engler, J.A., and Brouillette, C.G. (1997). Crystal structure of a truncated human apolipoprotein A-I suggests a lipid-bound conformation. Proc. Natl. Acad. Sci. USA 94: 12291-12296.  9356442 
Ehrhardt, A., Yant, S.R., Giering, J.C., Xu, H., Engler, J.A., and Kay, M.A. (2007). Somatic integration from a novel adenoviral hybrid-vector into hot-spots in mouse liver results in persistent transgene expression levels in vivo. Molecular Therapy 15: 146-156.  17164786 
Ehrhardt, A., Engler, J.A., Xu, H., Calos, M.A., Cherry, A., and Kay, M.A. (2006). Molecular analysis of chromosomal rearrangements in mammalian cells after FC31-mediated integration. Human Gene Therapy 17: 1077-1094.  17069535 
Brouillette, C.G., Dong, W.-j., Yang, Z.W., Ray, M.J., Protasevich, I.I., Cheung, H.C., and Engler, J.A. (2005). Förster resonance energy transfer measurements are consistent with a helical bundle model for lipid-free apolipoprotein A-I. Biochemistry 44: 16413-16425. This manuscript was named a “Hot Paper” in Biochemistry.  16342934 
Ehrhardt, A., Xu, H., Huang, Z., Engler, J.A., and Kay, M.A. (2005). A direct comparison of two non-viral gene therapy vectors for somatic integration: In vivo evaluation of the bacteriophage integrase phiC31 and the Sleeping Beauty transposase. Molecular Therapy 11: 695-706.  15851008 
Joung, I., Harber, G., Gerecke, K.M., Carroll, S.L., Collawn, J.F., and Engler, J.A. (2005). Improved gene delivery into neuroglial cells using a fiber-modified adenovirus vector. Biophys. Biochem. Res. Comm. 328: 1182-1187.  15708001 
Pritchard, D.G., Dong, S., Baker, J.R., and Engler, J.A. (2004). The bifunctional peptidoglycan lysin of Streptococcus agalactiae bacteriophage B30. Microbiology 150: 2079-2087.  15256551 
Pandya, A.Y., Talley, L.I., Frost, A.R., Fitzgerald, T.J., Trivedi, V., Chakravarthy, M., Chhieng, D.C., Grizzle, W.E., Engler, J.A., Krontiras, H., Bland, K.I., LoBuglio, A.F., Lobo-Ruppert, S., and Ruppert, J.M. (2004). Nuclear localization of KLF4 is associated with an aggressive phenotype in early stage breast cancer. Clin. Cancer Res. 10: 2709-2719.  15102675 
Aznavoorian, S., Moore, B.A., Alexander, L.D., Hallit, S., Windsor, L.J., and Engler, J.A. (2001). Membrane Type I-Matrix Metalloproteinase Mediated Degradation of Type I Collagen by Oral Squamous Cell Carcinoma Cells. Cancer Research 61: 6264-6275.  11507081 
Lee, J.H., Engler, J.A., Collawn, J.F., and Moore, B.A. (2001). Receptor mediated uptake of peptides that bind the human transferrin receptor. Eur. J. Biochem.:268: 2004-2012.  11277922 
Koppaka, V., Silvestro, L, Engler, J.A., Brouillette, C.G., and Axelsen, P.H. (1999). The structure of human apolipoprotein A-I in discoidal lipid complexes: Evidence for the “belt” model. J. Biol. Chem 274: 14541-14544.  10329643 
Noe, B.D. and Engler, J.A. (2009). Novel Approaches to Expanding and Assessing RCR Education for Graduate Students. In: Global Perspectives on Research Ethics and Scholarly Integrity, Proceedings of the 2008 Strategic Leaders Global Summit on Graduate Education, Council of Graduate Schools, pp. 64-67.   
Engler, J.A. and Hong, J.S. (2007). Chapter 21: Characterization of the Adenovirus Fiber Protein. In: Adenovirus Methods and Protocols, Volume 2 (A.E. Tollefson, M. Suppuswamy and W.S.M. Wold, eds.), Second Edition, Humana Press, Totowa, New Jersey. ISBN: 978-1-58829-901-7.