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Faculty Detail     Name JEFFREY A ENGLER   Campus Address HUC 504 Zip 1150 Phone 205-934-4734 E-mail engler@uab.edu Other websites

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Biochemistry & Molecular Genetics  Biochemistry & Molecular Genetics Professor Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Professor Center  Arthritis & Musculoskeletal Diseases Center  Arthritis & Musculoskeletal Diseases Center Professor Center  Pathology   Cell Adhesion & Matrix Research Center Professor Center  Center for AIDS Research  Center for AIDS Research Professor Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor Center  Ctr for Glial Bio in Med  Ctr for Glial Bio in Med Professor Center  Cystic Fibrosis Research Center  Cystic Fibrosis Research Center Professor

Graduate Biomedical Sciences Affiliations Biochemistry and Molecular Genetics Program  Medical Scientist Training Program

Biographical Sketch  Jeffrey A. Engler completed undergraduate studies in chemistry at the University of California, Santa Barbara (B.S. 1971) and graduate studies in biochemistry at the University of Wisconsin (Ph.D. in 1977). His postdoctoral studies at Cold Spring Harbor Laboratory in Long Island, New York led to a staff appointment there in 1980. Twice during his tenure there, the Leukemia Society of America awarded support for his work on adenoviruses. Dr. Engler joined the faculty at UAB in 1982, and he is currently Professor of Biochemistry and Molecular Genetics. He was an Editor for the journal GENE from 1986 to 2008. In May, 2006, he was selected as Associate Dean for Academic Affairs in the UAB Graduate School.

Society Memberships Organization Name Position Held Org Link American Association for Biochemistry and Molecular Biology      American Association for the Advancement of Science      American Society for Cell Biology      American Society for Gene Therapy      American Society for Microbiology      American Society for Virology

Research/Clinical Interest Title Supporting Graduate Student Education and Development Description Since being appointed as Associate Dean for Academic Affairs in the UAB Graduate School, I have ended my laboratory research activities. Currently, I am interested in embedding research ethics and scholarly integrity education into the graduate curriculum. I teach the Scientific Integrity course for biomedical graduate students and postdocs each Fall and Spring semester. I was the Director of the Ronald E. McNair Postbaccalaureate Achievement Program (funded by the US Department of Education) from 2006 through 2012 and am currently the Director of the Postbaccalaureate Research and Education Program (PREP) funded by the National Institute of General Medical Sciences (NIGMS). I also oversee the Professional Development and "English as a Second Language" programs within the Graduate School.

Selected Publications  Publication PUBMEDID Ehrhardt, A., Yant, S.R., Giering, J.C., Xu, H., Engler, J.A., and Kay, M.A. (2007). Somatic integration from a novel adenoviral hybrid-vector into hot-spots in mouse liver results in persistent transgene expression levels in vivo. Molecular Therapy 15: 146-156.  17164786  Ehrhardt, A., Engler, J.A., Xu, H., Calos, M.A., Cherry, A., and Kay, M.A. (2006). Molecular analysis of chromosomal rearrangements in mammalian cells after FC31-mediated integration. Human Gene Therapy 17: 1077-1094.  17069535  Brouillette, C.G., Dong, W.-j., Yang, Z.W., Ray, M.J., Protasevich, I.I., Cheung, H.C., and Engler, J.A. (2005). Förster resonance energy transfer measurements are consistent with a helical bundle model for lipid-free apolipoprotein A-I. Biochemistry 44: 16413-16425. This manuscript was named a “Hot Paper” in Biochemistry.  16342934  Ehrhardt, A., Xu, H., Huang, Z., Engler, J.A., and Kay, M.A. (2005). A direct comparison of two non-viral gene therapy vectors for somatic integration: In vivo evaluation of the bacteriophage integrase phiC31 and the Sleeping Beauty transposase. Molecular Therapy 11: 695-706.  15851008  Joung, I., Harber, G., Gerecke, K.M., Carroll, S.L., Collawn, J.F., and Engler, J.A. (2005). Improved gene delivery into neuroglial cells using a fiber-modified adenovirus vector. Biophys. Biochem. Res. Comm. 328: 1182-1187.  15708001  Pritchard, D.G., Dong, S., Baker, J.R., and Engler, J.A. (2004). The bifunctional peptidoglycan lysin of Streptococcus agalactiae bacteriophage B30. Microbiology 150: 2079-2087.  15256551  Pandya, A.Y., Talley, L.I., Frost, A.R., Fitzgerald, T.J., Trivedi, V., Chakravarthy, M., Chhieng, D.C., Grizzle, W.E., Engler, J.A., Krontiras, H., Bland, K.I., LoBuglio, A.F., Lobo-Ruppert, S., and Ruppert, J.M. (2004). Nuclear localization of KLF4 is associated with an aggressive phenotype in early stage breast cancer. Clin. Cancer Res. 10: 2709-2719.  15102675  Aznavoorian, S., Moore, B.A., Alexander, L.D., Hallit, S., Windsor, L.J., and Engler, J.A. (2001). Membrane Type I-Matrix Metalloproteinase Mediated Degradation of Type I Collagen by Oral Squamous Cell Carcinoma Cells. Cancer Research 61: 6264-6275.  11507081  Lee, J.H., Engler, J.A., Collawn, J.F., and Moore, B.A. (2001). Receptor mediated uptake of peptides that bind the human transferrin receptor. Eur. J. Biochem.:268: 2004-2012.  11277922  Koppaka, V., Silvestro, L, Engler, J.A., Brouillette, C.G., and Axelsen, P.H. (1999). The structure of human apolipoprotein A-I in discoidal lipid complexes: Evidence for the “belt” model. J. Biol. Chem 274: 14541-14544.  10329643  First Prev   1 2 of  2  Next Last

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