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Faculty Detail     Name J EDWIN BLALOCK   Campus Address MCLM 896 Zip 0005 Phone 205-934-6439 E-mail blalock@uab.edu Other websites

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Medicine  Med - Pulmonary/Allergy/Critical Care Professor Secondary  Cell, Developmntl, & Integrative Biology  Cell, Developmntl, & Integrative Biology Professor Secondary  Neurobiology  Neurobiology Professor Center  Arthritis & Musculoskeletal Diseases Center  Arthritis & Musculoskeletal Diseases Center Professor Center  Center for AIDS Research  Center for AIDS Research Professor Center  Civitan International Research Center  Civitan International Research Center Professor Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor Center  General Clinical Research Center  Comprehensive Neuroscience Center Professor Center  Cystic Fibrosis Research Center  Cystic Fibrosis Research Center Professor Center  Medicine  Ctr Cardiovasc Bio Professor

Graduate Biomedical Sciences Affiliations Cellular and Molecular Biology Program  Hughes Med-Grad Fellowship Program  Immunology  Integrative Biomedical Sciences  Medical Scientist Training Program  Neuroscience  Pathobiology and Molecular Medicine  Waiting to be Seated

Biographical Sketch  J. Edwin Blalock, Professor, received his B.S. and Ph.D. degrees in 1971 and 1976, respectively,from the University of Florida. After one year postdoctoral training at the University of Texas Medical Branch, Galveston, he joined the faculty in 1977, and earned the title of Professor of Microbiology in 1984. Dr. Blalock joined the UAB faculty in 1986 as Professor of Physiology and Biophysics. Dr. Blalock joined the Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine in 2009.

Society Memberships Organization Name Position Held Org Link American Association of Immunologists

Research/Clinical Interest Title Rational Drug and Vaccine Design/Neutrophilic Inflammation Description Unrelenting neutrophilic inflammation is a driving force in many human diseases. Research in the Blalock laboratory has focused on understanding the cause(s) of and potential treatments for this aberrant process. In what some consider a paradigm altering observation, the group has found that at inflammatory sites, neutrophil degradation of connective tissue proteins generates novel peptide fragments that can attract a new wave of neutrophils. In certain individuals, it is believed that this neutrophil-mediated process becomes uncontrolled, leading to self-propagating inflammation and chronic disease. In particular, a tripeptide (proline-glycine-proline, PGP) derived from collagen fragmentation, has been shown to attract and activate neutrophils via receptors previously thought to be only utilized by classical chemokines such as interleukin-8 (IL-8). Moreover, chronic administration of this peptide into the airways of experimental animals causes robust neutrophil influx and a disease similar to emphysema with alveolar enlargement and right ventricular hypertrophy. Consequently, the research has focused on airway disorders characterized by a chronic neutrophilic inflammation such as chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF) and lung transplantation organ rejection. In COPD and CF, these researchers have apparently identified a unique proteolytic pathway leading to collagen breakdown and PGP generation. This seems to involve matrix metalloproteases (MMPs) and a novel serine protease, prolyl endopeptidase (PE); these enzymes have been found to be elevated in these disorders. Collectively, these findings have far-reaching translational potential for human pulmonary disorders, in particular, and chronic inflammatory diseases, in general. This is rapidly being implemented in the diagnostic arena where PGP and certain isoforms appear to be biomarkers for COPD, CF, and chronic lung transplant rejection. Future studies will examine whether PGP and its isoforms are prognostic for disease progression and efficacy of certain therapeutic regimens. Rational drug design has led to the development of a variety of PGP antagonists and MMP/PE inhibitors that target this novel pathway of neutrophilic inflammation and, consequently, are prototypes for drugs to treat chronic inflammatory conditions.

Selected Publications  Publication PUBMEDID Jackson, P.L., B.D. Noerager, M.J. Jablonsky, M.T. Hardison, B.D. Cox, J.C. Patterson, B. Dhanapal, J.E. Blalock, D.D. Muccio. 2011. A CXCL8 receptor antagonist based on the structure of N-acetyl-proline-glycine-proline. Eur J Pharmacol 668:435-442.  21458447  Sahay, B., A. Singh, A. Gnanamani, R.L. Patsey, J.E. Blalock, T.J. Sellati. 2011. CD14 signaling reciprocally controls collagen deposition and turnover to regulte the development of lyme arthritis. Am J Pathol 178(2):724-734.  21281805  Xu, X., P.L. Jackson, S. Tanner, M.T. Hardison, M. Abdul Roda, J.E. Blalock, A. Gaggar. 2011. A self-propagating matrix metalloprotease-9 (MMP-9) dependent cycle of chronic neutrophilic inflammation. PLos One Jan 13;6(1):e15781  21249198  Braber, S., P.J. Koelink, P.A. Henricks, P.L. Jackson, F.P. Nijkamp, J. Garssen, A.D. Kraneveld, J.E. Blalock. G. Folkerts. 2011. Cigarette smoke-induced emphysema in mice is associated with prolyl endopeptidase, an enzyme involved in collagen breakdown. Am J Physiol Lung Cell Mol Physiol 300(2):L255-265.  21112944  Snelgrove, R.J., P.L. Jackson, M.T. Hardison, B.D. Noerager, A. Kinloch, A. Gaggar, S. Shastry, S.M. Rowe, Y.M. Shim, T. Hussell, J.E. Blalock. 2010. A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation. Science 330(6000):90-104.  20813919  Gaggar, A., S.M. Rowe, M. Hardison, J.E. Blalock. 2010. Proline-glycine-proline (PPG) and high mobility group box protein-1 (HMGB1): Potential mediators of cystic fibrosis airway inflammation. Open Respir Med J 4:32-38.  20448817  Jackson, P.L., X. Xu, L. Wilson, N.M. Weathington, J.P. Clancy, J.E. Blalock. A. Gaggar. 2010. Human neutrophil elastase-mediated cleavage sites of MMP-9 and TIMP-1: implications to cystic fibrosis proteolytic dysfunction. Mol Med 16(5-6):159-166.  20111696  O'Reilly,P.J., M.T. Hardison, P.L. Jackson, X. Xu, R.J. Snelgrove, A. Gaggar, F.S. Galin, J.E. Blalock. 2009. Neutrophils contain prolyl endopeptidase and generate the chemotactic peptide, PGP, from collagen. J Neuroimmunol 217(1-2):51-54.  19875179  O'Reilly,P., P.L. Jackson, B. Noerager, S. Parker, M. Dransfield, A. Gaggar, J.E. Blalock. 2009. N-alpha-PGP and PGP, potential biomarkers and therapeutic targets for COPD. Respir Res 10:38  19450278  Hardison, M.T., F.S. Galin, C.E. Calderon, U.V. Djekic, S.B. Parker, K.M. Wille, P.L. Jackson, R.A. Oster, K.R. Young, J.E. Blalock, A. Gaggar. 2009. The presence of a matrix-derived neutrophil chemoattractant in bronchiolitis obliterans syndrome after lung transplantation. J Immunol 182(7):4423-4431.  19299743  First Prev   1 2 of  2  Next Last

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