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Faculty Detail     Name KEVIN F DYBVIG   Campus Address KAUL 720A Zip 0024 Phone 205-934-9327 E-mail dybvig@uab.edu Other websites

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Genetics   Genetics Research Div Professor Secondary  Microbiology  Microbiology Associate Professor Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Professor

Graduate Biomedical Sciences Affiliations Cellular and Molecular Biology Program  Genetics and Genomic Sciences  Immunology  Integrative Biomedical Sciences  Integrative Genetics Graduate Program  Medical Scientist Training Program  Microbiology  Waiting to be Seated

Biographical Sketch  Kevin F. Dybvig (b. 1954), Professor of Genetics and Associate Professor of Microbiology, completed his undergraduate studies in physics at Kenyon College (B.A., 1976) and graduate studies in biophysics at the University of Rochester (M.S., 1978; Ph.D., 1981), studying the basic biology and genetics of mycoplasmas. He attended Washington University (1981-1983) for postdoctoral studies concerning the regulation of avian heat shock proteins and joined UAB in 1984 for additional postdoctoral studies in the area of mycoplasmal pathogenic mechanisms. He joined the UAB faculty in 1987.

Society Memberships Organization Name Position Held Org Link International Organization for Mycoplasmology  Past Chair  http://mycoplasmas.vm.iastate.edu/

Research/Clinical Interest Title Pathogenic mechanisms of mycoplasmas Description Dr. Dybvig’s research is focused on the basic biology and pathogenic mechanisms of mycoplasmas. The mycoplamas are a group of bacteria that cause a variety of chronic diseases including pneumonia and arthritis in humans and animals. The experimental infection of murine animals with mycoplasmas serves as models for understanding host-pathogen interactions in humans. A major effort is directed towards understanding the development of pneumonia caused by infection with the respiratory and genital pathogen Mycoplasma pulmonis. A second major effort is directed toward understanding the development of arthritis caused by infection of Mycoplasma arthritidis. Mycoplasmal factors associated with disease severity, host factors associated with protection, and host factors associated with high risk are under study.

Selected Publications  Publication PUBMEDID Simmons, W. L., Daubenspeck, J. M., Osborne, J. D., Balish, M. F., Waites, K. B., and Dybvig, K. Type 1 and type 2 strains of Mycoplasma pneumoniae form different biofilms. Microbiology 159: 737-747, 2013.  23412845  Shaw, B. M., Daubenspeck, J. M., Simmons, W. L., and Dybvig, K. EPS-I polysaccharide protects Mycoplasma pulmonis from phagocytosis. FEMS Microbiol. Lett. 338:155-160, 2013.   23190331  Bolland, J. R., Simmons, W. L., Daubenspeck, J. M., and Dybvig, K. Mycoplasma polysaccharide protects against complement. Microbiology 158:1867-1873, 2012.  22504437  Bolland, J. R. and Dybvig, K. Mycoplasma pulmonis Vsa proteins and polysaccharide modulate adherence to pulmonary epithelial cells. FEMS Microbiol. Lett. 331:25-30, 2012.  22428866  Shaw, B. M., Simmons, W. L., and Dybvig, K. The Vsa shield of Mycoplasma pulmonis is antiphagocytic. Infect. Immun. 80:704-709, 2012.  22083715  Luo, W., Yu, H., Cao, Z, Schoeb, T. R., Marron, M., and Dybvig, K. Association of M. arthritidis mitogen with lethal toxicity but not with arthritis in mice. Infect. Immun. 75: 4989-4998, 2008.   18779340  Dybvig, K., Zuhua, C., Lao, P., Jordan, D. S., French, C. T., Tu, A.-H. T., and Loraine, A. E. Genome of Mycoplasma arthritidis. Infect. Immun. 76: 4000-4008, 2008.  18573899  French, C. T. French, Lao, P., Loraine, A. E., Matthews, B. T., Yu, H., and Dybvig, K. Large-scale transposon mutagenesis of Mycoplasma pulmonis. Mol. Microbiol. 69:67-76, 2008.  18452587  Dybvig, K., Lao, P., Jordan, D. S., and Simmons, W. L. Fewer essential genes in mycoplasmas than previous studies suggest. FEMS Microbiol. Lett. 311:51-55, 2010.  2974803  Daubenspeck, J. M., Bolland, J. R., Luo, W., Simmons, W. L., and Dybvig, K. Identification of exopolysaccharide-deficient mutants of Mycoplasma pulmonis. Mol. Microbiol. 72:1235-1245, 2009.  2752295  First Prev   1 2 of  2  Next Last

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