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Faculty Detail     Name DAVID D CHAPLIN   Campus Address BBRB 859 Zip 2170 Phone 205-934-3917 E-mail dchaplin@uab.edu Other websites PubMed Listing

Education Undergraduate  Harvard College    1973  A.B.  Medical School  Washington University School of Medicine    1980  M.D.  Graduate  Washington University School of Medicine    1980  Ph.D.  Residency  Univ. of Texas, Southwestern Medical School    1982  M.D.  Fellowship  Harvard University    1984  Ph.D.

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Microbiology  Microbiology Professor Secondary  Medicine  Med - Pulmonary/Allergy/Critical Care Professor Center  Arthritis & Musculoskeletal Diseases Center  Arthritis & Musculoskeletal Diseases Center Professor Center  Comprehensive Cancer Center  Comprehensive Cancer Center Professor Center  General Clinical Research Center  Ctr for Clinical & Translational Sci Professor

Graduate Biomedical Sciences Affiliations Cellular and Molecular Biology Program  Hughes Med-Grad Fellowship Program  Immunology

Biographical Sketch  Dr. Chaplin completed his undergraduate education at Harvard University in 1973, then undertook graduate training in the MD/PhD program at Washington University, graduating in 1980. He completed two years of Internal Medicine Residency at U of Texas/Southwestern Medical School, Parkland Memorial Hospital. His post-doctoral research training was with Dr. J.G. Seidman in the Department of Genetics at Harvard Medical School, studying the genetics of the murine major histocompatibility complex. In 1984, he accepted a position as Associate Investigator of the Howard Hughes Medical Institute and Assistant Professor of Medicine, Molecular Microbiology, and Genetics at Washington University in St. Louis. He was promoted to Associate Professor in 1992, and Professor in 1995. He was Director of the Division of Allergy and Immunology from 1994-2001. In July 2001, he joined the faculty of UAB as Charles H. McCauley Professor and Chairman of the Department of Microbiology.

Society Memberships Organization Name Position Held Org Link American Academy of Allergy Asthma and Immunology      American Association for the Advancement of Science      American Society for Microbiology      Association of American Physicians      Association of Medical School Microbiology & Immunology Chairs      Clinical Immunology Society      Southeastern Branch American Society for Microbiology      The American Association of Immunologists      The American Society for Clinical Investigation

Research/Clinical Interest Title Interplay between innate and adaptive immunity in asthmatic inflammation Description Dr. Chaplin’s laboratory aims to define the ways innate immune stimuli modulate allergic inflammatory responses that are manifest in tissues through the action of the adaptive immune response. He has a special interest in the ways commensal and pathogenic microbes that are present in the lung alter allergic inflammatory responses such as those that underlie asthmatic inflammation. He is testing the hypothesis that airway microbes impact the quality and quantity of asthmatic inflammation largely through their induction of myeloid-derived regulatory cells (MDRC). Lung and airway MDRC, defined by Dr. Chaplin’s laboratory in 2011, constitute several discrete populations of cells that determine the overall inflammatory tone in the tissues through their production of cytokines, chemokines, and reactive nitrogen and oxygen free radical species. Dr. Chaplin’s laboratory demonstrated in studies using a mouse model that superoxide-producing MDRC dramatically accentuate airway hyperresponsiveness after exposure to aerosolized antigen. In contrast, populations of nitric oxide-producing MDRC blunt airway hyperresponsiveness, suggesting that the nitric oxide/superoxide axis may be a valuable target for future development of novel anti-asthmatic therapeutics.

Selected Publications  Publication PUBMEDID Nabe T., Ikedo A., Hosokawa F., Kishima M., Fujii M., Mizutani N., Yoshino S., Ishihara K., Akiba S., Chaplin D.D. (2012): Regualatory role of antigen-induced interleukin-10, produced by CD4(+) T cells, in airway neutrophilia in a murine model for asthma. Eur. J. Pharmacol 677:154-62.  22209878  Deshane J., Zmijewski J.W., Luther R., Gaggar A., Deshane R., Lai J.F., Xu X., Spell M., Estell K., Weaver C.T., Abraham E., Schwiebert L.M., Chaplin D.D. (2011). Free radical-producing myeloid-derived regulatory cells: potent activators and suppressors of lung inflammation and airway hyperresponsiveness. Mucosal Immunol 4:503-18.  21471960  Deshane J., Chaplin D.D. (2010): Folicular Dendritic Cell Makes Environmental Sense. Immunity 33:2-4.  20643332  Zindl C.L., Chaplin D.D. (2010): Immunology. Tumor immune evasion. Science 328:697-698.   20448171  Jung Y.W., Zindl C.L., Lai J.-F., Weaver C.T., Chaplin D.D. (2009): Matrix metalloproteinases induced by Gr-1+ cells are crucial for recruitment of Th cells into airways. Eur J Immunol 39:2281-2292.   19593770  Zindl C.L., Kim T.H., Zeng M., Archambault A.S., Grayson M.H., Choi K., Schreiber R.D., Chaplin D.D. (2009): LTalpha1beta2 controls postnatal and adult spleen marginal sinus vascular structure and function. Immunity 30:408-420.   19303389  Le T.L., Chaplin D.D. (2008): Intra-clonal competition inhibits the formation of high affinity antibody secreting cells. J Immunol 181:6027-6037.  18941192  Matsumoto M., Zhou Y., Matsuo S., Nakanishi H., Hirose K., Oura H., Arase S., Ishida-Yamamoto A., Bando Y., Izumi K., Kiyonari H., Oshima N., Nakayama R., Matsushima A., Hirota F., Mouri Y., Kuroda N., Sano S., Chaplin D.D. (2008): Targeted deletion of the murine corneodesmosin gene delineates its essential role in skin and hair physiology. Proc Natl Acad Sci USA 105:6720-6724.  18436651  Jung Y.W., Schoeb T.R., Weaver C.T., Chaplin D.D. (2006): Antigen and lipopolysaccharide play synergistic roles in the effector phase of airway inflammation in mice. Am J Pathol 168:1425-1434.   16651610  Chaplin D.D., Zindl C.L. (2006): Taking control of follicular dendritic cells. Immunity 24:13-15.  16413918  First Prev   1 2 of  2  Next Last

Keywords Inflammation, Lymphoid tissues, Innate immunity, T cells, Macrophages, Microbiome

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