Back to Main

Faculty Detail     Name TODD JASON GREEN   Campus Address CBSE 128 Zip 4400 Phone 205-975-0591 E-mail tgreen@uab.edu Other websites

Faculty Appointment(s) Appointment Type Department Division Rank Primary  Microbiology  Microbiology Assistant Professor

Biographical Sketch  I was introduced to scientific work as an under-graduate researcher where I studied natural products chemistry. Here, I isolated naturally occurring compounds from plant material in search of potential therapeutic agents. Compounds that were active against various bacteria as well as compounds that were cytotoxic to cancer cell lines were discovered during this research period. Upon beginning my graduate career in the laboratory of Dr. Ming Luo, I began to study viruses with an emphasis in virus structure. This work has continued since I took my faculty position at UAB. Specifically, I have been involved with studying the structure of negative strand RNA viruses. Our work with the nucleocapsid of vesicular stomatitis virus (VSV) has been instrumental in showing how RNA is encapsidated and sequestered in the nucleocapsid as well as how the nucleocapsid is assembled. In addition, we have solved crystal structures of the VSV phosphoprotein P showing how P multimerizes. We have continued this research solving the structure of N with bound P protein. This has demonstrated how P interacts with the nucleocapsid and aided in formulating hypotheses about how the viral polymerase may be delivered to the active template for transcription and replication. The active template for both of these processes is the N protein with the encapsidated genome. Our research to date has contributed greatly to the field of structural virology. It has also aided in developing new experiments that continue within our lab.

Research/Clinical Interest Title Viral Transcription and Replication, Capsid Structure Description My current research interests include crystallographic studies of proteins involved in polynucleotide synthesis for negative strand RNA viruses. These efforts have included: structure determination of the nucleocapsid of VSV encapsidated with various sequences of RNA, as well as complexes of the nucleocapsid with the polymerase co-factor, P.

Selected Publications  Publication PUBMEDID Access to RNA encapsidated in the nucleocapsid of vesicular stomatitis virus. Green TJ, Rowse M, Tsao J, Kang J, Ge P, Zhou ZH, Luo M. J Virol. 2011 Mar;85(6):2714-22. doi: 10.1128/JVI.01927-10. Epub 2010 Dec 22.  21177817  Structure of human stabilin-1 interacting chitinase-like protein (SI-CLP) reveals a saccharide-binding cleft with lower sugar-binding selectivity. Meng G, Zhao Y, Bai X, Liu Y, Green TJ, Luo M, Zheng X. J Biol Chem. 2010 Dec 17;285(51):39898-904. doi: 10.1074/jbc.M110.130781. Epub 2010 Aug 19.  20724479  Cryo-EM model of the bullet-shaped vesicular stomatitis virus. Ge P, Tsao J, Schein S, Green TJ, Luo M, Zhou ZH. Science. 2010 Feb 5;327(5966):689-93. doi: 10.1126/science.1181766.  20133572  Characterization of a mumps virus nucleocapsidlike particle. Cox R, Green TJ, Qiu S, Kang J, Tsao J, Prevelige PE, He B, Luo M. J Virol. 2009 Nov;83(21):11402-6. doi: 10.1128/JVI.00504-09. Epub 2009 Aug 19.  19692473  Structure of the vesicular stomatitis virus nucleocapsid in complex with the nucleocapsid-binding domain of the small polymerase cofactor, P. Green TJ, Luo M. Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11713-8. doi: 10.1073/pnas.0903228106. Epub 2009 Jul 1.  19571006  Crystallization and preliminary X-ray crystallographic studies on SI-CLP, a novel human Glyco_18 domain-containing protein. Meng G, Bai X, Green TJ, Luo M, Zheng X. Protein Pept Lett. 2009;16(3):336-8.  19275751  Structure of the vesicular stomatitis virus nucleoprotein-RNA complex.Green TJ, Zhang X, Wertz GW, Luo M. Science. 2006 Jul 21;313(5785):357-60. Epub 2006 Jun 15.   16778022

© 2008 University of Alabama at Birmingham. All rights reserved. DisclaimerAbout this SiteGraphic Design Created by UAB Web Communications.
Calendar Designed by Medical Education Information Services. To report problems with the site, email us at meis@uab.edu. Last Revision: February 15, 2012.
The UAB School of Medicine Mailing Address: 1530 3rd Avenue South, FOT 1203, Birmingham AL 35294-3412